FlyBase Allele Report: Dmel\eca[KK109376]

General Information

Symbol

Dmel\eca^KK109376

Species

D. melanogaster

Name

FlyBase ID

FBal0236273

Feature type

allele

Associated gene

Dmel\eca

Associated Insertion(s)

Carried in Construct

P{KK109376}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109376}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109376

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile, with Scer\GAL4^Act5C.PI

(Saleem et al., 2012)

lethal, with Scer\GAL4^Act5C.PI

(Saleem et al., 2012)

male semi-sterile, with Scer\GAL4^Act5C.PI, Scer\GAL80^ts.αTub84B

(Saleem et al., 2012)

viable, with Scer\GAL4^Act5C.PI

(Saleem et al., 2012)

Phenotype Manifest In

wing margin, with Scer\GAL4^hh.PU

(Port et al., 2011)

wing margin | somatic clone, with Scer\GAL4^Act5C.PI

(Port et al., 2011)

Detailed Description

Statement

Reference

Flies expressing eca^KK109376 during adulthood under the control of Scer\GAL4^Act5C.PI and Scer\GAL80^ts.αTub84B are viable but female flies lay fewer egg per day compared to controls. Male fertility is also reduced.

(Saleem et al., 2012)

Expression of eca^KK109376 using Scer\GAL4^hh.PU leads to loss of posterior wing margin tissue.

Expression of eca^KK109376 in clones using Scer\GAL4^Act5C.PI frequently leads to loss of posterior wing margin tissue.

(Port et al., 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

eca^KK109376, Scer\GAL4^ey.PU, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of wg^hs.2sev

(Port et al., 2011)

Additional Comments

Genetic Interactions

Statement

Reference

wg^hs.2sev rough eyes are suppressed when eca^KK109376 is expressed using both Scer\GAL4^ey.PU and Scer\GAL4^GMR.PU.

(Port et al., 2011)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v101388

P{KK109376}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

eca^KK109376

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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