FlyBase Allele Report: Dmel\Cisd[KK109403]

General Information

Symbol

Dmel\Cisd^KK109403

Species

D. melanogaster

Name

FlyBase ID

FBal0236294

Feature type

allele

Associated gene

Dmel\Cisd

Associated Insertion(s)

Carried in Construct

P{KK109403}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109403}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109403

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates porphyria

modeled by Irp-1A^KK105828

(Huynh et al., 2019)

ameliorates Parkinson's disease 6

modeled by Pink1^B9

(Martinez et al., 2024)

ameliorates Parkinson's disease 2

modeled by park²⁵

(Martinez et al., 2024)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of adult locomotory behavior | progressive, with Scer\GAL4^da.G32

(Martinez et al., 2024)

viable, with Scer\GAL4^phtm.PO

(Huynh et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression via P{GAL4-tim.E}27 or P{cry-GAL4.Z}17 (in the presence of Dcr-2^Scer\UAS.cDa) does not significantly affect circadian rhythmicity in locomotor activity assays in constant darkness.

(Mandilaras and Missirlis, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cisd^KK109403/Scer\GAL4^da.G32 is a suppressor of decreased rate of adult locomotory behavior phenotype of Pink1^B9

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^unspecified is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^unspecified is a suppressor of short lived phenotype of Pink1^B9

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^da.G32 is a suppressor of decreased rate of adult locomotory behavior phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^unspecified is a suppressor of decreased cell number | adult stage phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^unspecified is a suppressor of short lived phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^Mef2.PR is a suppressor of decreased rate of adult locomotory behavior phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of visible | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of visible | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of increased cell death | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of decreased rate of adult locomotory behavior phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of decreased cell number | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of increased cell death | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of decreased rate of adult locomotory behavior phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of decreased cell number | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

NOT Suppressor of

Statement

Reference

Cisd^KK109403/Scer\GAL4^nSyb.PS is a non-suppressor of decreased rate of adult locomotory behavior phenotype of park²⁵

(Martinez et al., 2024)

Other

Statement

Reference

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has decreased rate of adult locomotory behavior phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has visible | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has increased cell death | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has decreased cell number | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Irp-1A^KK105828, Scer\GAL4^phtm.PO has lethal phenotype

(Huynh et al., 2019)

Cisd^KK109403, Irp-1B^KK108179, Scer\GAL4^phtm.PO has viable phenotype

(Huynh et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cisd^KK109403/Scer\GAL4^unspecified is a suppressor of adult dopaminergic neuron | decreased number phenotype of Pink1^B9

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^da.G32 is a suppressor of mitochondrion phenotype of Pink1^B9

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^da.G32 is a suppressor of flight muscle phenotype of Pink1^B9

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^unspecified is a suppressor of adult dopaminergic neuron | decreased number phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^da.G32 is a suppressor of mitochondrion phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^da.G32 is a suppressor of flight muscle phenotype of park²⁵

(Martinez et al., 2024)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of adult dopaminergic neuron | decreased number phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^Mef2.PR is a suppressor of larval muscle cell | larval stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of wing phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^Mef2.PR is a suppressor of endoplasmic reticulum | larval stage phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of adult thorax phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of wing phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of mitochondrion | adult stage phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of flight muscle cell phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of adult dopaminergic neuron | decreased number phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^Mef2.PR is a suppressor of larval muscle cell | larval stage phenotype of park¹

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^Mef2.PR is a suppressor of endoplasmic reticulum | larval stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of adult thorax phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^Mef2.PR is a suppressor of wing phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of mitochondrion | adult stage phenotype of Pink1^B9

(Ham et al., 2023)

Cisd^KK109403/Scer\GAL4^hs.PB is a suppressor of flight muscle cell phenotype of Pink1^B9

(Ham et al., 2023)

Other

Statement

Reference

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has wing phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has adult thorax phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Pink1^B9, Scer\GAL4^hs.PB has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Scer\GAL4^hs.PB, park¹ has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has wing phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has adult thorax phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has flight muscle cell phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has mitochondrion | adult stage phenotype

(Ham et al., 2023)

Cisd^KK109403, Cisd^UAS.Tag:HA, Pink1^B9, Scer\GAL4^hs.PB has adult dopaminergic neuron | decreased number phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has wing phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has adult thorax phenotype

(Ham et al., 2023)

Cisd^KK109403, Itpr^UAS.cVa, Scer\GAL4^hs.PB, park¹ has flight muscle cell phenotype

(Ham et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104501

P{KK109403}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

CG1458^KK109403

Cisd2^IR

(Huynh et al., 2019)

Cisd2^KK109403

Cisd^KK109403

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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