FlyBase Allele Report: Dmel\grnd[KK109939]

General Information

Symbol

Dmel\grnd^KK109939

Species

D. melanogaster

Name

FlyBase ID

FBal0236564

Feature type

allele

Associated gene

Dmel\grnd

Associated Insertion(s)

Carried in Construct

P{KK109939}

Also Known As

UAS-Grnd RNAi, UAS-grnd^RNAi, grnd-RNAi, UAS-grnd-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK109939}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK109939

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates carcinoma

modeled by dlg1^GD4689

(de Vreede et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

majority die during P-stage | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

partially lethal - majority die | nutrition conditional, with Scer\GAL4^Tub.PU

(Havula et al., 2022)

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of grnd^KK109939 under the control of Scer\GAL4^Ilp2.PR does not significantly affect pupal body size (assayed by pupal volume), as compared to controls.

(de Vreede et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^nub.PU/grnd^KK109939 is a suppressor | partially of increased cell death | larval stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Scer\GAL4^nub.PU/grnd^KK109939 is a suppressor | partially of visible | adult stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Scer\GAL4^nub.PU/grnd^KK109939 is a suppressor | partially of decreased size | adult stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Scer\GAL4^hh-Gal4/grnd^KK109939 is a suppressor | partially of neoplasia | larval stage phenotype of Alg3^tid2/Alg3^tid1

(de Vreede et al., 2018)

grnd^KK109939/Scer\GAL4^rn-GAL4-5 is a suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, crb^intra.UAS

(Andersen et al., 2015)

grnd^KK109939/Scer\GAL4^rn-GAL4-5 is a suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, crb^{IntraY10A.E16A.UAS.Tag:MYC}

(Andersen et al., 2015)

grnd^KK109939/Scer\GAL4^rn-GAL4-5 is a suppressor of neoplasia phenotype of Scer\GAL4^rn-GAL4-5, Syx7^GD2767

(Andersen et al., 2015)

grnd^KK109939, Scer\GAL4^Act5C.PP is a suppressor of neoplasia phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, dlg1^GD4689

(Andersen et al., 2015)

grnd^KK109939/Scer\GAL4^Act5C.PP is a suppressor of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of Scer\GAL4^Act5C.PP, egr^UAS.cMa

(Andersen et al., 2015)

grnd^KK109939/Scer\GAL4^Act5C.PP is a suppressor of FlyBase_internaltransgene_features:cell lethal:cell lethal | somatic clone phenotype of Scer\GAL4^Act5C.PP, scrib^GD11666

(Andersen et al., 2015)

grnd^KK109939, Scer\GAL4^Act5C.PP is a suppressor of neoplasia phenotype of Ras85D^V12.UAS, Scer\GAL4^Act5C.PP, scrib¹

(Andersen et al., 2015)

NOT Suppressor of

Statement

Reference

grnd^KK109939, Scer\GAL4^hh.PU is a non-suppressor of neoplasia | larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689

(Muzzopappa et al., 2017)

grnd^KK109939, Scer\GAL4^hh.PU is a non-suppressor of neoplasia | larval stage phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh.PU, rod^GD8768

(Muzzopappa et al., 2017)

Other

Statement

Reference

Scer\GAL4^Act5C.PP, egr^UAS.cMa, grnd^KK109939 has increased cell death | somatic clone | cell non-autonomous phenotype

(Andersen et al., 2015)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Scer\GAL4^GMR.PU, egr^UAS.cMa, grnd^KK109939 has eye phenotype, non-suppressible by wgn^KO

(Andersen et al., 2015)

Suppressor of

Statement

Reference

Scer\GAL4^nub.PU/grnd^KK109939 is a suppressor | partially of wing phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Scer\GAL4^nub.PU/grnd^KK109939 is a suppressor | partially of wing disc | larval stage phenotype of RpS3^Plac92, yki^B5

(Wada et al., 2021)

Scer\GAL4^hh-Gal4/grnd^KK109939 is a suppressor | partially of wing disc phenotype of Alg3^tid2/Alg3^tid1

(de Vreede et al., 2018)

Scer\GAL4^en-e16E/grnd^KK109939 is a suppressor of wing disc phenotype of Alg9^c02021

(de Vreede et al., 2018)

grnd^KK109939/Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, egr^UAS.cMa

(Andersen et al., 2015)

NOT Suppressor of

Statement

Reference

grnd^KK109939, Scer\GAL4^hh.PU is a non-suppressor of wing disc phenotype of Ras85D^V12.UAS, Scer\GAL4^hh.PU, dlg1^GD4689

(Muzzopappa et al., 2017)

grnd^KK109939, Scer\GAL4^hh.PU is a non-suppressor of wing disc phenotype of BacA\p35^UAS.cHa, Scer\GAL4^hh.PU, rod^GD8768

(Muzzopappa et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The Scer\GAL4^GMR.PU egr^Scer\UAS.cMa small eye phenotype is partially rescued through co-expression of grnd^KK109939, resulting in a 'hanging eye' phenotype.

(Andersen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v104538

P{KK109939}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG10176^KK109939

grnd^KK109939

Name Synonyms

Secondary FlyBase IDs

References (13)

Report Sections

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