Open Close
General Information
Symbol
Dmel\Dop1R2KK110947
Species
D. melanogaster
Name
FlyBase ID
FBal0237126
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-DopR2 RNAi
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Dop1R2KK110947 driven in the dorsal fan-shaped body by Scer\GAL4GMR23E10 results in flies sleeping significantly more during the day and late hours of the night than parental controls; daytime sleep bouts are prolonged without affecting their frequency.

Focal dopamine application onto dorsal fan-shaped body neurons leads to hyperpolarization and suppresses spiking in controls; this suppression is significantly blocked in Scer\GAL4GMR23E10>Dop1R2KK110947 neurons. Prolonged dopamine application switches neurons in controls from electrical excitability (ON) to quiescence (OFF); this does not occur in Scer\GAL4GMR23E10>Dop1R2KK110947 neurons.

Expression of Dop1R2KK110947 under the control of Scer\GAL4dimm-929 does not affect sensitivity to (S,Z,Z)-CH503 (a more potent stereoisomer of the gustatory sex pheromone CH503). As in wild type flies, courtship defects are seen in response to (S,Z,Z)-CH503.

As in wild-type, female flies expressing DopR2KK110947 under the control of Scer\GAL4Gr5a.8.5 show an increased sugar-sensitive proboscis extension reflex in response to either L-Dopa feeding or 6 hours of wet starvation.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Dop1R2KK110947
DopR2KK110947
Name Synonyms
Secondary FlyBase IDs
    References (8)