FlyBase Allele Report: Dmel\crc[KK111018]

General Information

Symbol

Dmel\crc^KK111018

Species

D. melanogaster

Name

FlyBase ID

FBal0237163

Feature type

allele

Associated gene

Dmel\crc

Associated Insertion(s)

Carried in Construct

P{KK111018}

Also Known As

UAS-Atf4^RNAi, atf4 RNAi, UAS-ATF4-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK111018}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK111018

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates Parkinson's disease

modeled by park²⁵

(Celardo et al., 2017)

modeled by Pink1^B9

(Celardo et al., 2017)

ameliorates prion disease

modeled by Hsap\PRNP^V129.UAS

(Fernandez-Funez et al., 2017)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased fecundity | female, with Scer\GAL4^Lsp2.3.1

(Vasudevan et al., 2022)

increased cell death | oogenesis, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

increased cell death | oogenesis, with Scer\GAL4^{VP16.nanos.UTR}

(Grmai et al., 2024)

increased size | adult stage, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

visible | maternal effect, with Scer\GAL4^Lsp2.3.1

(Vasudevan et al., 2022)

Phenotype Manifest In

adult fat body, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

dorsal appendage | maternal effect, with Scer\GAL4^Lsp2.3.1

(Vasudevan et al., 2022)

egg chamber | decreased number, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

egg chamber | decreased number, with Scer\GAL4^{VP16.nanos.UTR}

(Grmai et al., 2024)

lipid droplet | adult stage, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

oocyte, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

yolk granule | decreased number, with Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Scer\GAL4^Lsp2.3.1, crc^KK111018 has increased cell death | oogenesis phenotype, non-enhanceable by mTor^UAS.Tag:MYC/Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

Suppressed by

Statement

Reference

Scer\GAL4^Lsp2.3.1, crc^KK111018 has increased cell death | oogenesis phenotype, suppressible by Scer\GAL4^Lsp2.3.1/bmm^UAS.cGa

(Grmai et al., 2024)

Scer\GAL4^Lsp2.3.1, crc^KK111018 has increased size | adult stage phenotype, suppressible by Scer\GAL4^Lsp2.3.1/bmm^UAS.cGa

(Grmai et al., 2024)

NOT suppressed by

Statement

Reference

Scer\GAL4^Lsp2.3.1, crc^KK111018 has increased cell death | oogenesis phenotype, non-suppressible by mTor^UAS.Tag:MYC/Scer\GAL4^Lsp2.3.1

(Grmai et al., 2024)

Enhancer of

Statement

Reference

Scer\GAL4^da.PU/crc^KK111018 is an enhancer of visible | adult stage phenotype of Pink1^B9

(Celardo et al., 2017)

Scer\GAL4^da.PU/crc^KK111018 is an enhancer of abnormal locomotor behavior | adult stage phenotype of Pink1^B9

(Celardo et al., 2017)

Scer\GAL4^da.PU/crc^KK111018 is an enhancer of partially lethal phenotype of park²⁵

(Celardo et al., 2017)

Scer\GAL4^da.PU/crc^KK111018 is an enhancer of visible | adult stage phenotype of park²⁵

(Celardo et al., 2017)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/crc^KK111018 is a non-enhancer of decreased cell number | larval stage | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Scer\GAL4^da.PU/crc^KK111018 is a non-enhancer of partially lethal phenotype of Pink1^B9

(Celardo et al., 2017)

Suppressor of

Statement

Reference

crc^KK111018, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/crc^KK111018 is a non-suppressor of decreased cell number | somatic clone | larval stage phenotype of scrib¹

(Zheng et al., 2023)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^Lsp2.3.1, crc^KK111018 has egg chamber | decreased number phenotype, suppressible by Scer\GAL4^Lsp2.3.1/bmm^UAS.cGa

(Grmai et al., 2024)

Scer\GAL4^Lsp2.3.1, crc^KK111018 has lipid droplet | adult stage phenotype, suppressible by Scer\GAL4^Lsp2.3.1/bmm^UAS.cGa

(Grmai et al., 2024)

Scer\GAL4^Lsp2.3.1, crc^KK111018 has adult fat body phenotype, suppressible by Scer\GAL4^Lsp2.3.1/bmm^UAS.cGa

(Grmai et al., 2024)

Enhancer of

Statement

Reference

Scer\GAL4^da.PU/crc^KK111018 is an enhancer of adult thorax phenotype of Pink1^B9

(Celardo et al., 2017)

Scer\GAL4^da.PU/crc^KK111018 is an enhancer of adult thorax phenotype of park²⁵

(Celardo et al., 2017)

NOT Enhancer of

Statement

Reference

Scer\GAL4^Act.PU/crc^KK111018 is a non-enhancer of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Suppressor of

Statement

Reference

crc^KK111018, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Hsap\PRNP^V129.UAS, Scer\GAL4^GMR.PU

(Myers et al., 2022)

NOT Suppressor of

Statement

Reference

Scer\GAL4^Act.PU/crc^KK111018 is a non-suppressor of eye-antennal disc | somatic clone phenotype of scrib¹

(Zheng et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The increased lethality of Pink1^B9 mutant adults is not significantly worsened by expression of crc^KK111018 under the control of Scer\GAL4^da.PU in the mutant background but the penetrance of their crushed-thorax phenotype as well as the severity of their climbing ability defects is significantly increased, while the crc^KK111018 expressions enhances both the high lethality and the severity of the crushed-thorax phenotype of park²⁵ homozygous adults.

(Celardo et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v109014

P{KK111018}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ATF4^KK111018

(Myers et al., 2022)

crc^KK111018

crc^RNAi

(Vasudevan et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

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