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General Information
Symbol
Dmel\Cht2KK111252
Species
D. melanogaster
Name
FlyBase ID
FBal0237299
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of an inverted repeat.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of Cht2KK111252 under the control of Scer\GAL469B prevents the cuticle thickening during third instar larval stage and in contrast to controls no increase in number of chitin-lamellae in the procuticle is observed, the lamellae are also less organized, the cuticle assembly zone is diminished and the pore canals appear fragmented and are mis-distributed throughout the entire chitin matrix. Distribution of pore canals is comparable to wild-type in second instar larvae.

Scer\GAL469B-mediated expression results in larval cuticle molting defects - mutants show characteristic double-cuticles of head skeleton and posterior spiracles in the second and third instar larvae.

Scer\GAL469B-mediated expression results in pupal cuticle molting defects and interferes with normal wing extension.

Scer\GAL469B-mediated expression results in large epidermal lesions at wounded sites of first instar and immediate lethality.

Scer\GAL469B-mediated expression results in an extremely thin epidermal cuticle-ECM in third instars.

The 'cuticle assembly zone' (i.e. the chitin-ECM of the cuticle next to the apical cell surface of the epidermis) is barely detectable or absent in Scer\GAL469B Cht2KK111252 larvae - procuticle lamellae are irregularly stratified and their number does not increase during the third instar intermolt.

Unlike in wild type, Pseudomonas can penetrate the cuticle of Scer\GAL469B Cht2KK111252 larvae.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Cht2KK111252
Name Synonyms
Secondary FlyBase IDs
    References (3)