FB2025_01 , released February 20, 2025
Allele: Dmel\ths759
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General Information
Symbol
Dmel\ths759
Species
D. melanogaster
Name
FlyBase ID
FBal0239103
Feature type
allele
Associated gene
Dmel\ths
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Klingseisen et al., 2009)
Progenitor genotype
P{EP}thsG18816
(Klingseisen et al., 2009)
Cytology
Description

Imprecise excision of the progenitor insertion, resulting in an internal deletion within the ths locus that deletes 84 amino acids of the FGF core domain.

(Klingseisen et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      adult ensheathing glial cell | P-stage (with Df(2R)ths238)

      (Wu et al., 2017)

      adult ensheathing glial cell | P-stage (with thse02026)

      (Wu et al., 2017)

      adult olfactory receptor neuron Or47b | P-stage (with Df(2R)ths238)

      (Wu et al., 2017)

      adult olfactory receptor neuron Or88a | P-stage (with Df(2R)ths238)

      (Wu et al., 2017)

      antennal lobe | P-stage (with Df(2R)ths238)

      (Wu et al., 2017)

      antennal lobe | P-stage (with thse02026)

      (Wu et al., 2017)

      antennal lobe glomerulus VA1d | P-stage (with Df(2R)ths238)

      (Wu et al., 2017)

      antennal lobe glomerulus VA1v | P-stage (with Df(2R)ths238)

      (Wu et al., 2017)

      astrocyte-like glial cell | embryonic stage

      (Stork et al., 2014)

      embryonic/larval midgut longitudinal visceral muscle cell | embryonic stage 17

      (Reim et al., 2012)

      embryonic/larval midgut longitudinal visceral muscle cell | third instar larval stage

      (Reim et al., 2012)

      glial cell projection | embryonic stage

      (Stork et al., 2014)

      longitudinal trunk visceral muscle primordium | embryonic stage 12

      (Reim et al., 2012)

      longitudinal trunk visceral muscle primordium | embryonic stage 12 (with Df(2R)BSC25)

      (Reim et al., 2012)

      longitudinal trunk visceral muscle primordium | embryonic stage 13

      (Reim et al., 2012)

      longitudinal trunk visceral muscle primordium | embryonic stage 13 (with Df(2R)BSC25)

      (Reim et al., 2012)

      mesoderm

      (Klingseisen et al., 2009)

      muscle cell of ventral oblique muscle 4

      (Klingseisen et al., 2009)

      muscle cell of ventral oblique muscle 5

      (Klingseisen et al., 2009)

      muscle cell of ventral oblique muscle 6

      (Klingseisen et al., 2009)

      segment border muscle cell

      (Klingseisen et al., 2009)
      Detailed Description
      Statement
      Reference

      ths759 homozygous embryos do not show significant defects in cardioblast number or patterning.

      (Schwarz et al., 2018)

      ths759/thse02026 as well as ths759/Df(2R)ths238 transheterozygotes show overall decrease in the number of ensheathing glial cells and reduction of their processes in the developing antennal lobes during late pupal stages. The axons from the olfactory receptor neurons Or88a and Or47b innervating the VA1v and VA1d glomeruli to reach their target area in the ventrolateral antennal lobe but they fail to establish exclusive territories for their axonal arborizations and their axonal terminals partially overlap in ths759/Df(2R)ths238 mutants.

      (Wu et al., 2017)

      Mutant embryos show a weak but significant defect in the migration of ventral astrocytes and in the infiltration of astrocyte processes into the neuropil.

      (Stork et al., 2014)

      Homozygous ths759 mutant stage 17 embryos show a reduction in the number of longitudinal visceral muscle (LVM) fibres around the midgut, particularly in the anterior portion where large areas are devoid of LVM fibres. The LVM founder cells are present at normal numbers in stage 11 embryos. Although some embryos develop with interruptions in the TVM, in those with complete TVMs, by stage 12 many of the founders lose contact with the trunk visceral mesoderm (TVM) rather than spreading out across it. By stage 13 a large number of rounded and shrunken cells are seen some distance from the TVM.

      ths759/Df(2R)BSC25 mutant stage 17 embryos show a reduction in the number of longitudinal visceral muscle (LVM) fibres around the midgut, particularly in the anterior portion where large areas are devoid of LVM fibres. The LVM founder cells are present at normal numbers in stage 11 embryos. Although some embryos develop with interruptions in the TVM, in those with complete TVMs, by stage 12 many of the founders lose contact with the trunk visceral mesoderm (TVM) rather than spreading out across it. By stage 13 a large number of rounded and shrunken cells are seen some distance from the TVM.

      Homozygous ths759 mutant larval guts contain 5-8 longitudinal visceral muscle fibres per half side compared to 9-11 in wild type.

      (Reim et al., 2012)

      Unequal spreading of mesoderm cells can be seen in stage 8 homozygous embryos. Mesoderm-ectoderm attachment is occasionally uneven along the anterior-posterior axis. Defects in mesoderm monolayer formation are not seen.

      Cells at the dorsal edge of the mesoderm form only thin, long protrusions during dorsolateral migration in homozygous embryos, as occurs in wild type.

      Homozygous embryos have defects in the ventral oblique muscles VO4, VO5 and VO6. Duplications of the segment border muscle are seen.

      (Klingseisen et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      ths759/ths[+] is a suppressor of lethal | recessive phenotype of pyrS0439

      (Reim et al., 2012)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      References (7)