FlyBase Allele Report: Dmel\Pink1[RNAi.UAS.cYa]

The expression of Pink1^dsRNA.UAS under the control of Scer\GAL4^Mhc.PU leads to adults displaying wing posture defects, collapsed thoraxes and impaired jumping activity. Adult thoraxes present an interrupted muscles layout, with disorganized myofibrils. Indirect flight muscles show swollen mitochondria.

(Xue et al., 2022)

Young (1-3 days) flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^tim.PE show defective rhythmicity of circadian locomotor activity under free-running (constant dark) conditions.

(Julienne et al., 2017)

Expression of Pink1^dsRNA.UAS under the control of Scer\GAL4^Ddc.PL results in decreased lifespan and severely impaired adult locomotion, but Scer\GAL4^GMR.PF-driven expression does not induce any eye morphology defects.

(M'Angale and Staveley, 2017)

The expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PU leads to mitochondria fragmentation, despite of normal cristae morphology, in adult indirect flight muscles, as compared to controls.

(Meng et al., 2017)

Adult flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PU adults display wing posture defects, reduced jumping ability anf mitochondrial aggregation phenotype in muscles.

(Gehrke et al., 2015)

Expression of Pink1^{dsRNA.Scer\UAS} driven by Scer\GAL4^Mhc.PW increases abnormal wing posture compared to controls.

(Sen et al., 2015)

Down-regulation of Pink1, through expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW leads to mitochondrial degeneration.

(Shiba-Fukushima et al., 2014)

Mitochondrial length is increased when Pink1^{dsRNA.Scer\UAS} is expressed in indirect flight muscles under the control of Scer\GAL4^Mhc.PU.

(Shiba-Fukushima et al., 2014)

Aggregation of mitochondria is seen in the indirect flight muscles of animals expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

(Lee et al., 2013)

Flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW often have an abnormal wing posture and have reduced flight ability.

Expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW results in mitochondrial aggregation in muscle.

(Wu et al., 2013)

Expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW results in a drooped wing posture.

(Choo et al., 2012)

Expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ple.PF in larval motor neurons results in increased anterograde flux and velocity of axonal mitochondrial transport, but no significant change in retrograde mitochondrial transport flux or velocity, increased mitochondrial length, and accumulation of mitochondria in the most distal boutons of neuromuscular junctions, as compared with controls.

(Liu et al., 2012)

Flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW often have an abnormal wing posture and have a reduced lifespan.

(Imai et al., 2010)

Prominent mitochondrial aggregates form in the dorsolateral protocerebral posterior DA (dopaminergic) neuron cluster in animals expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ple.PF, and in addition tubular mitochondrial structure are also seen.

The fraction of cultured dopaminergic neurons having thread-like tubular mitochondria is higher in cells expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^ple.PF than in control cells.

(Yang et al., 2008)

Adult flies still eclose after treatment with Pink1^{dsRNA.Scer\UAS}, expressed under the control of Scer\GAL4^da.G32. Both sexes exhibit either a held-up or a drooped wing posture, whereas control flies always hold their wings parallel to the body axis. The penetrance of this phenotype increases with age: When raised at 29[o]C, approximately 20% of newly eclosed flies exhibit abnormal wing posture, whereas by 7 days of age nearly 100% of them display this phenotype. These flies exhibit no problem with walking, but their climbing ability is greatly reduced and their ability to fly is completely abolished by 10 days of age.

Flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 display an approximate 70% reduction in overall ATP level compared with control flies. Raising the flies at 18[o]C until eclosion (so minimizing the RNAi effect), and then shifting them to 29[o]C immediately after eclosion (to induce a strong RNAi effect) results in an ATP level that initially is comparable with that of control flies, but within a week, the level of ATP drops sharply to approximately 40% of the control level. It remains low after 2 weeks under this experimental condition.

Flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^da.G32 display a significantly reduced lifespan.

Expression of Pink1^{dsRNA.Scer\UAS}, under the control of Scer\GAL4^da.G32 results in severe disruption of the indirect flight muscles. Disrupted muscle integrity is found in both the wing elevator muscles (dorsal ventral muscles) and depressor muscles (dorsal longitudinal muscles).

Expression of Pink1^{dsRNA.Scer\UAS}, under the control of Scer\GAL4^Mhc.PW generates an abnormal wing posture and muscle disruption phenotype in approximately 40% of 7-day old flies raised at 29[o]C.

Expression of Pink1^{dsRNA.Scer\UAS}, under the control of either Scer\GAL4^da.G32 or Scer\GAL4^Mhc.PW results in indirect flight muscles that exhibit irregular and dispersed myofibril arrangement. The number of mitochondria is reduced, whereas many of the remaining mitochondria are grossly swollen, lacking electron-dense material, and showing disintegration of cristae. Electron-dense deposits are found within the area of indirect flight muscles that succumb to severe disruption. Abnormally swollen mitochondria are present within morphologically normal myofibrils.

The tergotrochanteral muscles (TTMs) remain normal in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW or Scer\GAL4^da.G32.

Expression of Pink1^{dsRNA.Scer\UAS}, under the control of Scer\GAL4^da.G32 induces extensive cell death (as visualised through TUNEL) in the indirect flight muscles at 4-days old, whereas age-matched controls flies do not show this. No cell death is observed in the indirect flight muscles in flies expressing Pink1^{dsRNA.Scer\UAS}, under the control of Scer\GAL4^Mhc.PW at 18[o]C. However, after shifting to 29[o]C continuously for 7 days, these flies exhibit extensive cell death.

Expression of Pink1^{dsRNA.Scer\UAS}, under the control of Scer\GAL4^ple.PF at 29[o]C results in a significant reduction of TH+ neurons in the lateral protocerebral posterior (PPL1) cluster (at 25-days old). The dorso-medial protocerebral cluster (PPM) also exhibits a modest reduction in neuronal number, whereas the other clusters are relatively unaffected. In newly eclosed flies, the dopamine content is comparable between control and Pink1^{dsRNA.Scer\UAS} flies. As the flies age, both control and Pink1^{dsRNA.Scer\UAS} flies exhibit age-dependent decline of dopamine levels. However, Pink1^{dsRNA.Scer\UAS} flies consistently exhibit a more dramatic reduction than the control flies.

(Yang et al., 2006)

External Data

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Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa has visible | adult stage phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Tsf1^KK103815 has visible | adult stage phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, enhanceable by Tim8^JF01533, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, enhanceable by Tim8^JF01533, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, enhanceable by Tom40^JF02030, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, enhanceable by Tom20^KK107626, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, enhanceable by Tim13^KK108559, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by clu^KK108024, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by clu^GD13926, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by park^KK107919, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by Atg1^GD7149, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has abnormal flight phenotype, enhanceable by trc^{K122A.UAS.L.Tag:FLAG}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by trc^{K122A.UAS.L.Tag:FLAG}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has abnormal flight phenotype, enhanceable by trc^{K122A+T453A.UAS.L}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by trc^{K122A+T453A.UAS.L}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by rictor^Δ2

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by rictor^JF01370, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by rictor^JF01086, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, enhanceable by Sin1^unspecified/Sin1^unspecified

(Wu et al., 2013)

NOT Enhanced by

Statement

Reference

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, non-enhanceable by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, non-enhanceable by Drp1^TH02258.N, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, non-enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, non-enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, non-enhanceable by Zip99C^UAS.cXa/mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, non-enhanceable by mfrn^NIG.4963R/Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Suppressed by

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has decreased rate of adult locomotory behavior phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, suppressible by mfrn^UAS.cWa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, suppressible by mfrn^UAS.cWa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Ddc.PL has short lived phenotype, suppressible | partially by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Ddc.PL has abnormal locomotor behavior | adult stage phenotype, suppressible by Buffy^UAS.cQa, Scer\GAL4^Ddc.PL

(M'Angale and Staveley, 2017)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, suppressible by pum^JF02267, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, suppressible by pum^JF02267, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible by rictor^UAS.cHa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has abnormal flight phenotype, suppressible by trc^short.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has abnormal flight phenotype, suppressible by trc^L.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has abnormal flight phenotype, suppressible by trc^S292E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has abnormal flight phenotype, suppressible by trc^T453E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible by trc^short.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible by trc^L.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible by trc^S292E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible by trc^T453E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has visible phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has visible phenotype, suppressible by Atg1^UAS.cSa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has visible phenotype, suppressible | partially by Miro^KK102189, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has visible phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has visible phenotype, suppressible by Atg1^UAS.cSa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has visible phenotype, suppressible | partially by Miro^KK102189, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A+T453A.UAS.L} has visible phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has visible phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible by APP-BP1^UAS.cKa, Scer\GAL4^Mhc.PW

(Choo et al., 2012)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Tub.PU has male semi-sterile phenotype, suppressible | partially by Scer\GAL4^Mhc.PW/APP-BP1^UAS.cKa

(Choo et al., 2012)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, suppressible | partially by Pgam5^NP0568

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has short lived phenotype, suppressible | partially by chico^unspecified

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has short lived phenotype, suppressible by Keap1^EY1/Keap1[+]

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has short lived phenotype, suppressible by Keap1^EY5/Keap1[+]

(Imai et al., 2010)

NOT suppressed by

Statement

Reference

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, non-suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, non-suppressible by Drp1^TH02258.N, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype, non-suppressible by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, non-suppressible by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, non-suppressible by Zip99C^UAS.cXa/mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has abnormal jumping phenotype, non-suppressible by mfrn^NIG.4963R/Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has short lived phenotype, non-suppressible by Pgam5^NP0568

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, non-suppressible by chico^unspecified

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, non-suppressible by Keap1^EY1/Keap1[+]

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has visible phenotype, non-suppressible by Keap1^EY5/Keap1[+]

(Imai et al., 2010)

Enhancer of

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW is an enhancer of visible phenotype of Scer\GAL4^Mhc.PW, clu^KK108024

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW is an enhancer of visible phenotype of Scer\GAL4^Mhc.PW, clu^GD13926

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Tub.PU is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, park^KK107919

(Sen et al., 2015)

Suppressor of

Statement

Reference

Su(H)^HM05110/Pink1^RNAi.UAS.cYa, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal neuroanatomy phenotype of N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Pink1^RNAi.UAS.cYa/Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of abnormal neuroanatomy phenotype of N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Other

Statement

Reference

Atg7^unspecified, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has visible | adult stage phenotype

(Xu et al., 2023)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa has wing phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Zip99C^UAS.cXa has adult thorax phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Tsf1^KK103815 has wing phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU, Tsf1^KK103815 has adult thorax phenotype, enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing | adult stage phenotype, enhanceable by Tim8^JF01533, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, enhanceable by Tim8^JF01533, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, enhanceable by Tim8^JF01533, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing | adult stage phenotype, enhanceable by Tom40^JF02030, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, enhanceable by Tom40^JF02030, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, enhanceable by Tom40^JF02030, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing | adult stage phenotype, enhanceable by Tom20^KK107626, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, enhanceable by Tom20^KK107626, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, enhanceable by Tom20^KK107626, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing | adult stage phenotype, enhanceable by Tim13^KK108559, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, enhanceable by eIF4G1^HMS00762, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, enhanceable by eIF4G1^HMS00762, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by clu^KK108024, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by clu^GD13926, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by park^KK107919, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by Atg1^GD7149, Scer\GAL4^Mhc.PW

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by rictor^Δ2

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, enhanceable by rictor^Δ2

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by trc^{K122A+T453A.UAS.L}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, enhanceable by trc^{K122A+T453A.UAS.L}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by rictor^JF01370, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by rictor^JF01086, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by Sin1^unspecified/Sin1^unspecified

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, enhanceable by trc^{K122A.UAS.L.Tag:FLAG}, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

NOT Enhanced by

Statement

Reference

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, non-enhanceable by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, non-enhanceable by Drp1^TH02258.N, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, non-enhanceable by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult thorax phenotype, non-enhanceable by mfrn^UAS.cWa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, non-enhanceable by Chchd2^H43/Chchd2^H43

(Meng et al., 2017)

Suppressed by

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult thorax phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has indirect flight muscle phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^ple.PU has mitochondrion phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^ple.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has indirect flight muscle phenotype, suppressible | partially by Hsap\FUNDC1^{Y18A.L21A.UAS.Tag:MYC}, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible | partially by Hsap\FUNDC1^{Y18A.L21A.UAS.Tag:MYC}, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrial crista phenotype, suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult thorax phenotype, suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult thorax phenotype, suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult somatic muscle cell of thorax phenotype, suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult somatic muscle cell of thorax phenotype, suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has myotube | adult stage phenotype, suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, suppressible by mfrn^UAS.cWa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult thorax phenotype, suppressible by mfrn^UAS.cWa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing | adult stage phenotype, suppressible by pum^JF02267, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by pum^JF02267, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by pum^JF02267, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by Pop2^GD12804, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by Pop2^GD12804, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by AGO1^TRiP.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by AGO1^TRiP.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by gw^RNAi.UAS.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by gw^RNAi.UAS.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by DCP1^VDRC.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by DCP1^VDRC.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by DCP2^HMS00115, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by DCP2^HMS00115, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has flight muscle cell phenotype, suppressible by glo^RNAi.UAS.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, suppressible by glo^RNAi.UAS.cUa, Scer\GAL4^Mhc.PU

(Gehrke et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion phenotype, suppressible by park^UAS.cSa, Scer\GAL4^Mhc.PU

(Shiba-Fukushima et al., 2014)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion phenotype, suppressible by park^SE.UAS, Scer\GAL4^Mhc.PU

(Shiba-Fukushima et al., 2014)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, suppressible by Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Lee et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has indirect flight muscle cell phenotype, suppressible by Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Lee et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by rictor^UAS.cHa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, suppressible by rictor^UAS.cHa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, suppressible by Sin1^UAS.Tag:FLAG, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by trc^short.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by trc^L.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by trc^S292E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by trc^T453E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, suppressible by trc^L.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, suppressible by trc^S292E.UAS.L, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has wing phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has wing phenotype, suppressible by Atg1^UAS.cSa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has wing phenotype, suppressible | partially by Miro^KK102189, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has mitochondrion phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has mitochondrion phenotype, suppressible by Atg1^UAS.cSa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has wing phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has wing phenotype, suppressible by Atg1^UAS.cSa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has wing phenotype, suppressible | partially by Miro^KK102189, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has mitochondrion phenotype, suppressible by Marf^RNAi.cUa.UAS, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A.UAS.L.Tag:FLAG} has mitochondrion phenotype, suppressible by Atg1^UAS.cSa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has wing phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, rictor^Δ2 has mitochondrion phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A+T453A.UAS.L} has wing phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW, trc^{K122A+T453A.UAS.L} has mitochondrion phenotype, suppressible by Hsap\PRKN^UAS.cYa, Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has eye phenotype, suppressible by APP-BP1^UAS.cKa, Scer\GAL4^Mhc.PW

(Choo et al., 2012)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible | partially by Pgam5^NP0568

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by Hsap\PINK1^UAS.cYa, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has indirect flight muscle cell phenotype, suppressible by Hsap\PINK1^UAS.cYa, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has muscle cell of leg depressor muscle phenotype, suppressible by Hsap\PINK1^UAS.cYa, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, suppressible by Hsap\PINK1^ΔC.UAS, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has indirect flight muscle cell phenotype, suppressible by Hsap\PINK1^ΔC.UAS, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has muscle cell of leg depressor muscle phenotype, suppressible by Hsap\PINK1^ΔC.UAS, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^da.G32 has mitochondrion phenotype, suppressible by Hsap\PINK1^UAS.cYa, Scer\GAL4^da.G32

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, suppressible by Hsap\PINK1^UAS.cYa, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^ple.PF has dopaminergic neuron phenotype, suppressible by Hsap\PINK1^UAS.cYa, Scer\GAL4^ple.PF

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa has dopaminergic neuron phenotype, suppressible by Scer\GAL4^ple.PF/Hsap\PINK1^UAS.cYa

(Yang et al., 2006)

NOT suppressed by

Statement

Reference

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, non-suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has indirect flight muscle phenotype, non-suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, non-suppressible by Hsap\FUNDC1^UAS.Tag:MYC, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, non-suppressible by Drp1^TH02258.N, Scer\GAL4^Mhc.PU

(Xu et al., 2023)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has indirect flight muscle cell phenotype, non-suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, non-suppressible by Tsf1^KK103815, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has indirect flight muscle cell phenotype, non-suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype, non-suppressible by Zip99C^UAS.cXa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype, non-suppressible by mfrn^NIG.4963R, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has adult thorax phenotype, non-suppressible by mfrn^UAS.cWa, Scer\GAL4^Mhc.PU

(Xue et al., 2022)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, non-suppressible by chico^unspecified

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, non-suppressible by Keap1^EY1/Keap1[+]

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has wing phenotype, non-suppressible by Keap1^EY5/Keap1[+]

(Imai et al., 2010)

Pink1^RNAi.UAS.cYa, Scer\GAL4^da.G32 has mitochondrion phenotype, non-suppressible by Hsap\PINK1^ΔC.UAS, Scer\GAL4^da.G32

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW has mitochondrion phenotype, non-suppressible by Hsap\PINK1^ΔC.UAS, Scer\GAL4^Mhc.PW

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa has dopaminergic neuron phenotype, non-suppressible by Scer\GAL4^ple.PF/Hsap\PINK1^ΔC.UAS

(Yang et al., 2006)

Pink1^RNAi.UAS.cYa, Scer\GAL4^ple.PF has dopaminergic neuron phenotype, non-suppressible by Hsap\PINK1^ΔC.UAS, Scer\GAL4^ple.PF

(Yang et al., 2006)

Enhancer of

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW is an enhancer of wing phenotype of Scer\GAL4^Mhc.PW, clu^KK108024

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW is an enhancer of wing phenotype of Scer\GAL4^Mhc.PW, clu^GD13926

(Sen et al., 2015)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Tub.PU is an enhancer of wing phenotype of Scer\GAL4^Tub.PU, park^KK107919

(Sen et al., 2015)

Suppressor of

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU is a suppressor of indirect flight muscle cell phenotype of Scer\GAL4^Mhc.PU, park^UAS.cSa

(Shiba-Fukushima et al., 2014)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU is a suppressor of mitochondrion phenotype of Scer\GAL4^Mhc.PU, park^UAS.cSa

(Shiba-Fukushima et al., 2014)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW is a suppressor of mitochondrion phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Lee et al., 2013)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW is a suppressor of indirect flight muscle cell phenotype of Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PW

(Lee et al., 2013)

Su(H)^HM05110/Pink1^RNAi.UAS.cYa, Scer\GAL4^insc-Mz1407 is a suppressor of type II neuroblast | increased number phenotype of N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

Pink1^RNAi.UAS.cYa/Myc^KK103869, Scer\GAL4^insc-Mz1407 is a suppressor of type II neuroblast | increased number phenotype of N^{UAS.Tag:V5,Tag:polyHis}, Scer\GAL4^insc-Mz1407

(Lee et al., 2013)

NOT Suppressor of

Statement

Reference

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU is a non-suppressor of indirect flight muscle cell phenotype of Scer\GAL4^Mhc.PU, park^SE.UAS

(Shiba-Fukushima et al., 2014)

Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU is a non-suppressor of mitochondrion phenotype of Scer\GAL4^Mhc.PU, park^SE.UAS

(Shiba-Fukushima et al., 2014)

Other

Statement

Reference

Atg7^unspecified, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has wing phenotype

(Xu et al., 2023)

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has mitochondrion | adult stage phenotype

(Xu et al., 2023)

Drp1^TH02258.N, Pink1^RNAi.UAS.cYa, Scer\GAL4^Mhc.PU has indirect flight muscle phenotype

(Xu et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

The reduced adult lifespan along with the impaired climbing ability characteristic for flies expressing Pink1^dsRNA.UAS under the control of Scer\GAL4^Ddc.PL is ameliorated by co-expression of Buffy^UAS.cQa. Adult flies expressing either Pink1^dsRNA.UAS or Buffy^UAS.cQa or both simultaneously under the control of Scer\GAL4^GMR.PF do not show any eye morphology defects.

(M'Angale and Staveley, 2017)

The mitochondria morphology defects in adult indirect flight muscles resulting from the expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PU are not enhanced by Chchd2^H43 homozygosity.

(Meng et al., 2017)

The mitochondrial aggregations in flight muscles along with the wing posture and jumping ability defects observed in adult flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PU are significantly improved by co-expression of pum^JF02267 but further enhanced by expression of Tim8^JF01533, Tom40^JF02030 or Tom20^KK107626. The abnormal wing posture is also exacerbated by co-expression of Tim13^KK108559 and the abnormal mitochondrial morphology in the flight muscles is partially suppressed by co-expression of any of the following: Pop2^GD12804, AGO1^TRiP.cUa, gw^{dsRNA.Scer\UAS.cUa}, DCP1^VDRC.cUa, DCP2^HMS00115 or glo^{dsRNA.Scer\UAS.cUa} but worsened further by expression of eIF4G1^HMS00762.

(Gehrke et al., 2015)

Co-expression of park^KK107919 or Atg1^GD7149 or clu^GD13926 or clu^KK108024 increases the percentage of abnormal wing posture seen in flies with Pink1^{dsRNA.Scer\UAS} driven by Scer\GAL4^Mhc.PW.

Co-expression of Pink1^{dsRNA.Scer\UAS} increases the percentage of abnormal wing posture seen in flies with clu^KK108024 or clu^GD13926 driven by Scer\GAL4^Mhc.PW.

(Sen et al., 2015)

The mitochondrial degeneration seen in Pink1^{dsRNA.Scer\UAS} mutants is not affected by down-regulation of ben (ben^GD1387).

(Shiba-Fukushima et al., 2014)

Expression of Pink1^{dsRNA.Scer\UAS} does not suppress the over-fragmentation of mitochondria seen when park^SE.Scer\UAS is expressed in indirect flight muscles under the control of Scer\GAL4^Mhc.PU.

Expression of Pink1^{dsRNA.Scer\UAS} suppresses the reduction in mitochondria length seen when park^Scer\UAS.cSa is expressed in indirect flight muscles under the control of Scer\GAL4^Mhc.PU.

Expression of park^SE.Scer\UAS suppresses the increase in mitochondrial length seen when Pink1^{dsRNA.Scer\UAS} is expressed under control of Scer\GAL4^Mhc.PU.

Expression of park^Scer\UAS.cSa suppresses the increase in mitochondrial length seen when Pink1^{dsRNA.Scer\UAS} is expressed under control of Scer\GAL4^Mhc.PU.

(Shiba-Fukushima et al., 2014)

Co-expression of N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} suppresses the aggregation of mitochondria seen in the indirect flight muscles of animals expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

Simultaneous co-expression of both Pink1^{dsRNA.Scer\UAS} and Su(H)^HM05110 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

Simultaneous co-expression of both Pink1^{dsRNA.Scer\UAS} and dm^KK103869 suppresses the increase in the number of type II neuroblasts which is seen in the central brain of animals expressing N^{Scer\UAS.T:SV5\V5,T:Zzzz\His6} under the control of Scer\GAL4^insc-Mz1407.

(Lee et al., 2013)

The abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is enhanced by rictor^Δ2/Y and by Sin1^unspecified/Sin1^unspecified.

The abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is enhanced by co-expression of either rictor^JF01370 or rictor^JF01086.

The abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is suppressed by co-expression of rictor^Scer\UAS.cHa.

The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is strongly suppressed by co-expression of rictor^Scer\UAS.cHa and moderately suppressed by co-expression of Sin1^{Scer\UAS.T:Zzzz\FLAG}.

The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is enhanced by rictor^Δ2.

Co-expression of either trc^{short.Scer\UAS}, trc^L.Scer\UAS, trc^{S292E.Scer\UAS} or trc^{T453E.Scer\UAS} suppresses the defects in flight ability caused by expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

Co-expression of either trc^{K122A.Scer\UAS.T:Zzzz\FLAG} or trc^{K122A+T453A.Scer\UAS} enhances the defects in flight ability caused by expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

Co-expression of either trc^{short.Scer\UAS}, trc^L.Scer\UAS, trc^{S292E.Scer\UAS} or trc^{T453E.Scer\UAS} suppresses the abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

Co-expression of either trc^{K122A.Scer\UAS.T:Zzzz\FLAG} or trc^{K122A+T453A.Scer\UAS} enhances the abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is suppressed by co-expression of either trc^L.Scer\UAS or trc^{S292E.Scer\UAS}.

The mitochondrial aggregation phenotype seen in the muscles of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is enhanced by co-expression of trc^{K122A+T453A.Scer\UAS}.

The ability of rictor^Δ2 to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is blocked by co-expression of either Marf^{miRNA.cUa.Scer\UAS} or Atg1^Scer\UAS.cSa.

The ability of rictor^Δ2 to enhance the abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is partially suppressed by co-expression of Miro^KK102189.

The ability of trc^{K122A.Scer\UAS.T:Zzzz\FLAG} to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is blocked by co-expression of either Marf^{miRNA.cUa.Scer\UAS} or Atg1^Scer\UAS.cSa.

The ability of trc^{K122A.Scer\UAS.T:Zzzz\FLAG} to enhance the abnormal wing posture phenotype seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is partially suppressed by co-expression of Miro^KK102189.

(Wu et al., 2013)

Expression of APP-BP1^Scer\UAS.cKa partially suppresses the drooped wing phenotype seen when Pink1^{dsRNA.Scer\UAS} is expressed under the control of Scer\GAL4^Mhc.PW.

(Choo et al., 2012)

Pgam5^NP0568 significantly suppresses the abnormal wing posture of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW, but fails to suppress the short lifespan phenotype of these flies.

chico^unspecified significantly suppresses the short lifespan phenotype of flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW, but fails to suppress the abnormal wing posture of these flies.

The abnormal wing posture caused by expression of Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is not suppressed Keap1^EY1/+ or Keap1^EY5/+, but the viability of aged flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW is increased by Keap1^EY1/+ or Keap1^EY5/+.

(Imai et al., 2010)

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\PARK2^Scer\UAS.cYa completely blocks the ability of rictor^Δ2 to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW.

Expression of Hsap\PARK2^Scer\UAS.cYa completely blocks the ability of trc^{K122A+T453A.Scer\UAS} to enhance the abnormal wing posture and mitochondrial aggregation phenotypes seen in flies expressing Pink1^{dsRNA.Scer\UAS} under the control of Scer\GAL4^Mhc.PW

(Wu et al., 2013)

Co-expression of Hsap\PINK1^Scer\UAS.cYa with Pink1^{dsRNA.Scer\UAS}, both under the control of Scer\GAL4^Mhc.PW, suppresses the abnormal wing and disrupted muscle phenotypes induced by Pink1^{dsRNA.Scer\UAS}.

Co-expression of Hsap\PINK1^ΔC.Scer\UAS with Pink1^{dsRNA.Scer\UAS}, both under the control of Scer\GAL4^Mhc.PW, fails to suppress the abnormal wing and disrupted muscle phenotypes induced by Pink1^{dsRNA.Scer\UAS}.

Mitochondrial integrity in Pink1^{dsRNA.Scer\UAS} (under the control of either Scer\GAL4^da.G32 or Scer\GAL4^Mhc.PW) mutants is restored through co-expression of Hsap\PINK1^Scer\UAS.cYa, but not co-expression of Hsap\PINK1^ΔC.Scer\UAS.

Co-expression of Hsap\PINK1^Scer\UAS.cYa but not Hsap\PINK1^ΔC.Scer\UAS, with Pink1^{dsRNA.Scer\UAS} (all under the control of Scer\GAL4^ple.PF), is able to suppress the Pink1^{dsRNA.Scer\UAS} dopaminergic neuron loss phenotype.

Co-expression of Hsap\PINK1^Scer\UAS.cYa but not Hsap\PINK1^ΔC.Scer\UAS, with Pink1^{dsRNA.Scer\UAS} (all under the control of Scer\GAL4^ple.PF), fully restores the level of dopamine in Pink1^{dsRNA.Scer\UAS} mutants.

The abnormal wing postures caused by expression of Pink1^{dsRNA.Scer\UAS} can be suppressed through co-expression of Hsap\PARK2^Scer\UAS.cYa (both under the control of Scer\GAL4^Mhc.PW), whereas co-expression of Hsap\PARK7^Scer\UAS.cYa has no effect. This suppression also restores myofibril integrity and mitochondrial morphology. Overexpression of Hsap\PARK2^Scer\UAS.cYa under the control of Scer\GAL4^da.G32 is able to restore ATP levels in Pink1^{dsRNA.Scer\UAS} flies, as well as restoring the number of TH+ neurons in the protocerebral posterior (PPL1) and dorso-medial protocerebral (PPM) clusters.While this overexpression exhibits a tendency to elevate brain dopamine levels in Pink1^{dsRNA.Scer\UAS} animals, this effect is not statistically significant.

(Yang et al., 2006)

Complementation and Rescue Data

Rescued by

Pink1^RNAi.UAS.cYa is rescued by Scer\GAL4^Mhc.PW/Pink1^UAS.cYa

(Yang et al., 2006)

Comments

The expression of Pink1^Scer\UAS.cYa, alongside Pink1^{dsRNA.Scer\UAS}, both under the control of Scer\GAL4^Mhc.PW, rescues the tissue-specific RNAi phenotype.

(Yang et al., 2006)

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Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Pink1^RNAi.UAS.cYa

Pink1^{dsRNA.Scer\UAS}

Pink1^dsRNA.UAS

Name Synonyms

Secondary FlyBase IDs

References (27)

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