FB2025_01 , released February 20, 2025
Allele: Dmel\cacJF02572
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General Information
Symbol
Dmel\cacJF02572
Species
D. melanogaster
Name
FlyBase ID
FBal0239273
Feature type
allele
Associated gene
Dmel\cac
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02572}
Also Known As
UAS-Cac-RNAi, UAS-cacRNAi, cac RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009.8.10)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009.8.10)
Mutagen
in vitro construct
(Perkins et al., 2009.8.10)
Progenitor genotype
Carried in construct
P{TRiP.JF02572}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.8.10)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02572
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  epilepsy
      CEA
      (Liu et al., 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of cacJF02572 under the control of Scer\GAL4slbo.2.6 leads to a prevalent border cell cluster disassociation phenotype, as well as border cell migration delay in some egg chamber.

      (Raza et al., 2019)

      The expression of cacJF02572 under the control of Scer\GAL4GMR75C05 does not lead to third instar larval locomotor defects in crawling assays, as compared to controls.

      (Lembke et al., 2017)

      cacJF02572 driven by Scer\GAL4elav-C155 does not cause temperature-sensitive phenotypes (no spontaneous seizure-like behaviors or paralysis at 38C).

      (Saras and Tanouye, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      cacJF02572 driven by Scer\GAL4elav-C155 partially suppresses bang sensitivity (reduces behavioral paralysis) in parabss1/Y or eas2/Y flies at room temperature. Driving cacJF02572 with Scer\GAL4Gad1.PU or Scer\GAL4ChAT.PU also suppresses bang sensitivity in eas2/Y flies to a lesser extent.

      (Saras and Tanouye, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cacJF02572
      Name Synonyms
      Secondary FlyBase IDs
        References (13)