FB2021_05, released October 15, 2021

Allele: Dmel\pAbpJF03104

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General Information
Symbol
Dmel\pAbpJF03104
Species
D. melanogaster
Name
FlyBase ID
FBal0239604
Feature type
allele
Associated gene
Dmel\pAbp
Associated Insertion(s)
Carried in Construct
P{TRiP.JF03104}
Key Links
Genomic Maps
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - RNAi
(Perkins et al., 2009)
in vitro construct - regulatory fusion
(Perkins et al., 2009)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{TRiP.JF03104}
      Cytology
      Nature of the lesion
      Statement
      Reference

      UAS regulatory sequences drive expression of an inverted repeat.

      (Perkins et al., 2009)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      pAbp
      Also carries
      loxP
      Associated Sequence Features
      dsRNA-JF03104
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis
      modeled by Hsap\TARDBPUAS.cEa
      (Kim et al., 2014)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of pAbpJF03104 (together with UAS-Dicer2 to enhance RNAi efficiency) under the control of Scer\GAL4bam.T:Hsim\VP16 results in highly penetrant tumorigenic phenotype due to spermatogonial overgrowth in adult testes.

      (Shan et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of pAbpJF03104 suppresses the reduction in climbing ability seen when Hsap\TARDBPScer\UAS.cEa is expressed under the control of Scer\GAL4elav.Switch.PO when flies are raised with RU486.

      (Kim et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      pAbpJF03104
      Name Synonyms
      Secondary FlyBase IDs
        References (4)