FB2025_01 , released February 20, 2025
Allele: Dmel\ykiS168A.UAS.Tag:V5
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General Information
Symbol
Dmel\ykiS168A.UAS.Tag:V5
Species
D. melanogaster
Name
FlyBase ID
FBal0239740
Feature type
allele
Associated gene
Dmel\yki
Associated Insertion(s)
Carried in Construct
P{UAS-yki.S168A.V5}
Also Known As
UAS-ykiS168A, UAS-YkiS168A:V5, UAS-yki:V5S168A, UAS-YkiS168A-V5
Key Links
Transgenic product class
missense_variant
(Oh and Irvine, 2009)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Oh and Irvine, 2009)
Mutagen
in vitro construct
(Oh and Irvine, 2009)
Progenitor genotype
Carried in construct
P{UAS-yki.S168A.V5}
Cytology
Description

Amino acid replacement: S168A.

(Oh and Irvine, 2009)

UAS regulatory sequences drive expression of a mutated form of yki which is tagged with Tag:V5.

(Oh and Irvine, 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
yki
Tagged with
Tag:V5
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  cancer
      CEA
      (Hodgson et al., 2021, Santabárbara-Ruiz and Léopold, 2021)
      model of  ovarian cancer
      CEA
      (Hall et al., 2010)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In

      abdominal nerve | third instar larval stage, with Scer\GAL446F

      (Zülbahar et al., 2018)

      abdominal nerve | third instar larval stage, with Scer\GAL4Gli.PU

      (Zülbahar et al., 2018)

      abdominal nerve | third instar larval stage, with Scer\GAL4repo.PU

      (Zülbahar et al., 2018)

      adult heart, with Scer\GAL4tin.CΔ4

      (Yu et al., 2015)

      anterior-posterior compartment boundary of the wing disc | third instar larval stage, with Scer\GAL4ptc-559.1

      (Mach et al., 2018)

      embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      embryonic/larval PNS perineurial glial cell | third instar larval stage, with Scer\GAL446F

      (Zülbahar et al., 2018)

      eye, with Scer\GAL4GMR.PF

      (Oh and Irvine, 2011, Oh and Irvine, 2009)

      eye, with Scer\GAL4GMR.PF, Scer\GAL80αTub84B.PL

      (Oh and Irvine, 2009)

      eye, with Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      eye disc | third instar larval stage, with Scer\GAL4ptc-559.1

      (Mach et al., 2018)

      eye disc | third instar larval stage, with Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      follicle cell, with Scer\GAL4Act5C.PI

      (Hall et al., 2010)

      larval brain | third instar larval stage, with Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      larval central nervous system | third instar larval stage, with Scer\GAL4insc-Mz1407

      (Poon et al., 2016)

      larval glial cell | third instar larval stage, with Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      larval optic anlage, with Scer\GAL4c768

      (Zhou and Luo, 2013)

      larval ventral nerve cord | third instar larval stage, with Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      PNS glial cell | third instar larval stage, with Scer\GAL4repo.PU

      (Zülbahar et al., 2018)

      subperineurial glial cell | third instar larval stage, with Scer\GAL4Gli.PU

      (Zülbahar et al., 2018)

      wing disc | somatic clone, with Scer\GAL4FRT.Act5C

      (Oh and Irvine, 2011)

      wing disc | third instar larval stage, with Scer\GAL4ptc-559.1

      (Mach et al., 2018)
      Detailed Description
      Statement
      Reference

      ykiS168A.UAS.Tag:V5 expression driven by Scer\GAL4insc-Mz1407 does not result in obvious signs of quiescence in the larval brain, as neuroblasts show the expected rounded morphology and do not show changes in cell division (both DNA replication/EdU staining and Mitosis/phospho-H3), as compared to controls.

      (Ly et al., 2019)

      Expressing ykiS168A.UAS.Tag:V5 under the control of Scer\GAL4ptc-559.1 stimulates severe tissue overgrowth in the wing and eye discs and results in a significant expansion of the anterior-posterior compartment boundary of the wing disc in third instar larvae.

      (Mach et al., 2018)

      Third instar larvae expressing ykiS168A.UAS.Tag:V5 under the control of Scer\GAL4repo.PU, Scer\GAL446F or Scer\GAL4Gli.PU exhibit bulges along peripheral nerves, which contain increased nuclei numbers respectively from glial, perineurial glial and subperineurial glial cells, as compared to controls.

      (Zülbahar et al., 2018)

      Expressing ykiS168A.UAS.Tag:V5 under the control of Scer\GAL4insc-Mz1407 results in a significant increase in volume in the central nervous system of third instar larvae.

      (Poon et al., 2016)

      Flies expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4tin.CΔ4 show cardiac hypertrophy: ventricular diameter at the end of systole and diastole is reduced compared with controls and the heart walls are thicker. The average ploidy of cardiomyocytes expressing ykiS168A.Scer\UAS.T:SV5\V5 is increased compared with controls.

      Flies expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4tin.CΔ4 and where expression is limited to the wandering third instar larval stage onwards (using Scer\GAL80ts.αTub84B) show reduced ventricular diameter at the end of diastole (EDD), whereas the EDD from flies that begin expressing ykiS168A.Scer\UAS.T:SV5\V5 in adulthood do not differ from controls.

      (Yu et al., 2015)

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GMR.PU results in eye overgrowth.

      (Zhang et al., 2015)

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4c768 results in overgrowth of the neuroepithelium in the third larval instar optic lobe.

      (Zhou and Luo, 2013)

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GMR.PF produces enlarged and irregular eyes.

      Wing disc clones expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4Scer\FRT.Act5C induce mild growth enhancement.

      (Oh and Irvine, 2011)

      Expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU induces a substantial increase in glial cell number in third instar larval eye discs. The size of the ventral nerve cord and brain hemispheres is increased and the total number of glial cells is increased throughout the brain - the optic stalk is thicker and contains many more glial cells, and an increased number of glial cells is seen in the outer cortex of the brain hemispheres. Ethyl deoxyuridine (EdU) labelling shows that glial expression of ykiS168A.Scer\UAS.T:SV5\V5 results in increased retinal glial cell proliferation compared to controls. As in wild type, central brain glia expressing ykiS168A.Scer\UAS.T:SV5\V5 are rarely seen to proliferate.

      (Reddy and Irvine, 2011)

      Overexpression of ykiS168A.Scer\UAS.T:SV5\V5 driven by Scer\GAL4Act5C.PI in somatic clones induces tumorigenesis in the ovarian follicular epithelium.

      (Hall et al., 2010)

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GMR.PF results in an enlarged eye which is folded due to the extensive overgrowth.

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4sd-SG29.1 results in an extended third instar larval stage and eventual late larval lethality.

      Flies carrying ykiS168A.Scer\UAS.T:SV5\V5 in the presence of two copies of Scer\GAL4GMR.PF and one copy of Scer\GAL80αTub84B.PL show only a subtle eye overgrowth.

      (Oh and Irvine, 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4ptc-559.1, ykiS168A.UAS.Tag:V5 has abnormal size | third instar larval stage phenotype, suppressible | partially by Hrb27CGD6964, Scer\GAL4ptc-559.1

      (Mach et al., 2018)

      Scer\GAL4Gli.PU, ykiS168A.UAS.Tag:V5 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Ntan1KK107726, Scer\GAL4Gli.PU

      (Zülbahar et al., 2018)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has abnormal neuroanatomy | third instar larval stage phenotype, suppressible by Ntan1UAS.cZa, Scer\GAL4repo.PU

      (Zülbahar et al., 2018)

      Scer\GAL4GMR.PU, taiUAS.cBa, ykiS168A.UAS.Tag:V5 has visible phenotype, suppressible by sdRNAi.UAS.cUa, Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      Scer\GAL4GMR.PU, taiUAS.cBa, ykiS168A.UAS.Tag:V5 has abnormal size | adult stage phenotype, suppressible by sdRNAi.UAS.cUa, Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      Scer\GAL4GMR.PU, ykiS168A.UAS.Tag:V5 has visible phenotype, suppressible by sdRNAi.UAS.cUa/Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      Scer\GAL4GMR.PU, ykiS168A.UAS.Tag:V5 has abnormal size | adult stage phenotype, suppressible by sdRNAi.UAS.cUa/Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      Scer\GAL4FRT.Act5C, ykiS168A.UAS.Tag:V5 has increased cell number | somatic clone phenotype, suppressible | partially by Mad12

      (Oh and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has increased cell number | third instar larval stage phenotype, suppressible by Scer\GAL4repo.PU/sdKK108877

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has increased cell number | third instar larval stage phenotype, suppressible by MadKK109050, Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has increased cell number | third instar larval stage phenotype, suppressible by hthKK108831/Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has increased cell number | third instar larval stage phenotype, suppressible by MycKK103869, Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)
      Suppressor of
      Statement
      Reference

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor of abnormal cell shape | larval stage phenotype of Scer\GAL4insc-Mz1407, picGD4128

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4insc-Mz1407, picGD4128

      (Ly et al., 2019)

      ykiS168A.UAS.Tag:V5, Scer\GAL4insc-Mz1407 is a suppressor of abnormal cell shape | larval stage phenotype of Cul4KK101901, Scer\GAL4insc-Mz1407

      (Ly et al., 2019)

      ykiS168A.UAS.Tag:V5, Scer\GAL4insc-Mz1407 is a suppressor | partially of decreased occurrence of cell division | larval stage phenotype of Cul4KK101901, Scer\GAL4insc-Mz1407

      (Ly et al., 2019)

      ykiS168A.UAS.Tag:V5, Scer\GAL4insc-Mz1407 is a suppressor | partially of abnormal neuroanatomy | larval stage phenotype of Cul4KK101901, Scer\GAL4insc-Mz1407

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor of abnormal cell shape | larval stage phenotype of Scer\GAL4insc-Mz1407, mahjHMS01260

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor of decreased occurrence of cell division | larval stage phenotype of Scer\GAL4insc-Mz1407, mahjHMS01260

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor of abnormal neuroanatomy | larval stage phenotype of Scer\GAL4insc-Mz1407, mahjHMS01260

      (Ly et al., 2019)

      Scer\GAL4FRT.Act5C/ykiS168A.UAS.Tag:V5 is a suppressor | partially of decreased cell number | somatic clone phenotype of Scer\GAL4FRT.Act5C, brkUAS.cJa

      (Oh and Irvine, 2011)

      ykiS168A.UAS.Tag:V5/Scer\GAL4GMR.PF is a suppressor of abnormal size | adult stage phenotype of Scer\GAL4GMR.PF, brkUAS.cJa

      (Oh and Irvine, 2011)

      ykiS168A.UAS.Tag:V5/Scer\GAL4GMR.PF is a suppressor of visible | adult stage phenotype of Scer\GAL4GMR.PF, brkUAS.cJa

      (Oh and Irvine, 2011)

      Scer\GAL4FRT.Act5C/ykiS168A.UAS.Tag:V5 is a suppressor of decreased cell number | somatic clone phenotype of Mad12

      (Oh and Irvine, 2011)
      NOT Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4ptc-559.1, ykiS168A.UAS.Tag:V5 has anterior-posterior compartment boundary of the wing disc | third instar larval stage phenotype, suppressible | partially by Hrb27CGD6964, Scer\GAL4ptc-559.1

      (Mach et al., 2018)

      Scer\GAL4Gli.PU, ykiS168A.UAS.Tag:V5 has subperineurial glial cell | third instar larval stage phenotype, suppressible by Ntan1KK107726, Scer\GAL4Gli.PU

      (Zülbahar et al., 2018)

      Scer\GAL4Gli.PU, ykiS168A.UAS.Tag:V5 has abdominal nerve | third instar larval stage phenotype, suppressible by Ntan1KK107726, Scer\GAL4Gli.PU

      (Zülbahar et al., 2018)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has PNS glial cell | third instar larval stage phenotype, suppressible by Ntan1UAS.cZa, Scer\GAL4repo.PU

      (Zülbahar et al., 2018)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has abdominal nerve | third instar larval stage phenotype, suppressible by Ntan1UAS.cZa, Scer\GAL4repo.PU

      (Zülbahar et al., 2018)

      Scer\GAL4tin.CΔ4, ykiS168A.UAS.Tag:V5 has adult heart phenotype, suppressible by Scer\GAL4tin.CΔ4/sdJF02514

      (Yu et al., 2015)

      Scer\GAL4tin.CΔ4, ykiS168A.UAS.Tag:V5 has adult heart phenotype, suppressible by sdGL00410/Scer\GAL4tin.CΔ4

      (Yu et al., 2015)

      Scer\GAL4tin.CΔ4, ykiS168A.UAS.Tag:V5 has adult heart phenotype, suppressible | partially by rlHMS00173/Scer\GAL4tin.CΔ4

      (Yu et al., 2015)

      Scer\GAL4tin.CΔ4, ykiS168A.UAS.Tag:V5 has adult heart phenotype, suppressible by TgiUAS.B/Scer\GAL4tin.CΔ4

      (Yu et al., 2015)

      Scer\GAL4GMR.PU, taiUAS.cBa, ykiS168A.UAS.Tag:V5 has eye phenotype, suppressible by sdRNAi.UAS.cUa, Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      Scer\GAL4GMR.PU, ykiS168A.UAS.Tag:V5 has eye phenotype, suppressible by sdRNAi.UAS.cUa/Scer\GAL4GMR.PU

      (Zhang et al., 2015)

      ykiS168A.UAS.Tag:V5 has wing disc | somatic clone phenotype, suppressible by Mad12

      (Oh and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has eye disc | third instar larval stage phenotype, suppressible by Scer\GAL4repo.PU/sdKK108877

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has larval glial cell | third instar larval stage phenotype, suppressible by Scer\GAL4repo.PU/sdKK108877

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has eye disc | third instar larval stage phenotype, suppressible by MadKK109050, Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has larval glial cell | third instar larval stage phenotype, suppressible by MadKK109050, Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has eye disc | third instar larval stage phenotype, suppressible by hthKK108831/Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has larval glial cell | third instar larval stage phenotype, suppressible by hthKK108831/Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has eye disc | third instar larval stage phenotype, suppressible by MycKK103869, Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)

      Scer\GAL4repo.PU, ykiS168A.UAS.Tag:V5 has larval glial cell | third instar larval stage phenotype, suppressible by MycKK103869, Scer\GAL4repo.PU

      (Reddy and Irvine, 2011)
      NOT suppressed by
      Suppressor of
      Statement
      Reference

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor | partially of larval neuroblast | larval stage phenotype of Scer\GAL4insc-Mz1407, picGD4128

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor | partially of larval brain | larval stage phenotype of Scer\GAL4insc-Mz1407, picGD4128

      (Ly et al., 2019)

      ykiS168A.UAS.Tag:V5, Scer\GAL4insc-Mz1407 is a suppressor | partially of larval neuroblast | larval stage phenotype of Cul4KK101901, Scer\GAL4insc-Mz1407

      (Ly et al., 2019)

      ykiS168A.UAS.Tag:V5, Scer\GAL4insc-Mz1407 is a suppressor | partially of larval brain | larval stage phenotype of Cul4KK101901, Scer\GAL4insc-Mz1407

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor of larval neuroblast | larval stage phenotype of Scer\GAL4insc-Mz1407, mahjHMS01260

      (Ly et al., 2019)

      Scer\GAL4insc-Mz1407/ykiS168A.UAS.Tag:V5 is a suppressor of larval brain | larval stage phenotype of Scer\GAL4insc-Mz1407, mahjHMS01260

      (Ly et al., 2019)

      ykiS168A.UAS.Tag:V5, Scer\GAL4c768 is a suppressor of larval optic anlage phenotype of RPA3GD4799, Scer\GAL4c768

      (Zhou and Luo, 2013)

      ykiS168A.UAS.Tag:V5/Scer\GAL4GMR.PF is a suppressor of eye phenotype of Scer\GAL4GMR.PF, brkUAS.cJa

      (Oh and Irvine, 2011)

      Scer\GAL4FRT.Act5C/ykiS168A.UAS.Tag:V5 is a suppressor of wing disc | somatic clone phenotype of Mad12

      (Oh and Irvine, 2011)

      Scer\GAL4FRT.Act5C/ykiS168A.UAS.Tag:V5 is a suppressor | partially of wing disc | somatic clone phenotype of Scer\GAL4FRT.Act5C, brkUAS.cJa

      (Oh and Irvine, 2011)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of sdJF02514 suppresses the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of sdGL00410 suppresses the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of MadJF01263 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of MadJF01264 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of MadGLV21013 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of hthJF02733 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of hthHMS01112 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of RafJF01185 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of RafJF01483 does not suppress the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of rlHMS00173 partially suppresses the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      Expression of TgiScer\UAS.B suppresses the cardiac hypertrophy seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4tin.CΔ4.

      (Yu et al., 2015)

      Co-expression of ykiS168A.Scer\UAS.T:SV5\V5 and taiScer\UAS.cBa under the control of Scer\GAL4GMR.PU results in severe oncogenic overgrowth of the eye.

      Co-expression of sddsRNA.Scer\UAS.cUa rescues the eye overgrowth of flies expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4GMR.PU, and also rescues the oncogenic effect of co-expression of ykiS168A.Scer\UAS.T:SV5\V5 and taiScer\UAS.cBa under the control of Scer\GAL4GMR.PU.

      (Zhang et al., 2015)

      Co-expression of ykiS168A.Scer\UAS.T:SV5\V5 significantly rescues the loss of neuroepithelium cells seen in the optic lobe of third instar larvae expressing RPA3GD4799 under the control of Scer\GAL4c768.

      (Zhou and Luo, 2013)

      A Mad12 mutant background partially suppresses the overgrowth seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed in wing disc clones under the control of Scer\GAL4Scer\FRT.Act5C. Suppression of growth is evident in the distal wing, but not in the proximal wing.

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 partially suppresses the underproliferation seen when brkScer\UAS.cJa is expressed in wing disc clones under the control of Scer\GAL4Scer\FRT.Act5C. Co-expression of tkvQ253D.Scer\UAS.cNc suppresses the growth defects further, producing some clone overgrowth, whilst the addition of MadScer\UAS.T:Zzzz\FLAG increases clone overgrowth even further.

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 suppresses the small eye phenotype seen when brkScer\UAS.cJa is expressed under the control of Scer\GAL4GMR.PF. When tkvQ253D.Scer\UAS.cNc is additionally expressed overgrown eyes are seen.

      (Oh and Irvine, 2011)

      Expression of sdKK108877 suppresses the increase in glial cell number seen in larval eye discs expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU.

      Expression of MadKK109050 suppresses the increase in glial cell number seen in larval eye discs expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU.

      Expression of hthKK108831 is unable to suppress the increase in glial cell number seen in larval eye discs expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU.

      Expression of ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU is unable to suppress the reduction in glial cell number seen in Df(3L)banΔ1 mutant larval eye discs. No suppression is seen when ykiS168A.Scer\UAS.T:SV5\V5 is expressed under the control of Scer\GAL4Act5C.PI or Scer\GAL4tub.PU.

      Expression of dmKK103869 (co-expressed with Dcr-2Scer\UAS.cDa) suppresses the increase in glial cell number seen in larval eye discs expressing ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU.

      Co-expression of dmScer\UAS.cZa and ykiS168A.Scer\UAS.T:SV5\V5 under the control of Scer\GAL4repo.PU results in substantial increase in the number of glial cells in the larval eye disc and brain, greater than when either is expressed alone. Ethyl deoxyuridine (EdU) staining shows that there is increased glial cell proliferation in the cortex compared to controls, whereas this is not seen in the individual mutants.

      (Reddy and Irvine, 2011)

      Co-expression of ykiS168A.Scer\UAS.T:SV5\V5 and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PF results in flies with greatly enlarged eyes.

      Co-expression of ykiS168A.Scer\UAS.T:SV5\V5, wtsScer\UAS.T:Hsap\MYC and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.PF results in flies with enlarged eyes.

      Large round clones are still observed in the wing disc when ykiS168A.Scer\UAS.T:SV5\V5 is co-expressed with wtsScer\UAS.T:Hsap\MYC and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Act5C.PI in the clones.

      Co-expression of exScer\UAS.cBa in clones expressing ykiS168A.Scer\UAS.T:SV5\V5, wtsScer\UAS.T:Hsap\MYC and hpoScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4Act5C.PI decreases the size and number of clones recovered in the wing disc.

      (Oh and Irvine, 2009)
      Xenogenetic Interactions
      Statement
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      Complementation and Rescue Data
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      Mutant
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      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      ykiS168A.Scer\UAS.T:SV5\V5
      ykiS168A.UAS.Tag:V5
      Name Synonyms
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        References (32)