expression driven by Scer\GAL4insc-Mz1407
does not result in obvious signs of quiescence in the larval brain, as neuroblasts show the expected rounded morphology and do not show changes in cell division (both DNA replication/EdU staining and Mitosis/phospho-H3), as compared to controls.
under the control of Scer\GAL4ptc-559.1
stimulates severe tissue overgrowth in the wing and eye discs and results in a significant expansion of the anterior-posterior compartment boundary of the wing disc in third instar larvae.
under the control of Scer\GAL4repo.PU
induces a substantial increase in glial cell number in third instar larval eye discs. The size of the ventral nerve cord and brain hemispheres is increased and the total number of glial cells is increased throughout the brain - the optic stalk is thicker and contains many more glial cells, and an increased number of glial cells is seen in the outer cortex of the brain hemispheres. Ethyl deoxyuridine (EdU) labelling shows that glial expression of ykiS168A.Scer\UAS.T:SV5\V5
results in increased retinal glial cell proliferation compared to controls. As in wild type, central brain glia expressing ykiS168A.Scer\UAS.T:SV5\V5
are rarely seen to proliferate.