Allele Dmel\Miro^Sd26

General Information
Symbol	Dmel\Miro^Sd26	Species	D. melanogaster
Name		FlyBase ID	FBal0239859
Feature type	allele	Associated gene	Dmel\Miro

Allele class
Mutagen	ethyl methanesulfonate
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Guo et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference A 39 bp deletion and frame-shifts Miro at I427, adding 12 abnormal amino acids. (Guo et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	locomotor behavior defective \| larval stage \| recessive (Guo et al., 2005) neurophysiology defective \| larval stage (with Miro^B682) (Guo et al., 2005) partially lethal - majority die \| larval stage \| recessive (Guo et al., 2005) partially lethal - majority die \| pupal stage \| recessive (Guo et al., 2005) phototaxis defective \| somatic clone (Guo et al., 2005)
Phenotype Manifest In
	mitochondrion & neuron \| larval stage (with Miro^B682) (Guo et al., 2005)
Detailed Description
	Statement Reference Gross eye morphology is normal but phototaxis is defective in flies whose eyes are homozygous for Miro[Sd26]. In neurons of Miro[Sd26]/Miro[B682] larvae, mitochondria are retained in the cell bodies and not properly distributed to neuronal processes - most neuromuscular junctions lack mitochondria. In Miro[B682]/Miro[Sd26] larvae, excitatory junction potential evoked by 10Hz stimulation of neuro-muscular junctions (NMJs) starts off normal, but, unlike wild-type, rapidly decays. (Guo et al., 2005)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	Miro^B682 (Guo et al., 2005) Miro^Sd10 (Guo et al., 2005) Miro^Sd23 (Guo et al., 2005) Miro^Sd32 (Guo et al., 2005)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Miro^Sd26
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Guo et al., 2005, Neuron 47(3): 379--393 The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses. [FBrf0188178]

Allele Dmel\MiroSd26

Allele Dmel\Miro^Sd26