|Feature type||allele||Associated gene||Dmel\Nc|
|Also Known As||DRONC11|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Caused by aberration|
|Phenotype Manifest In|
neuroblast & larval abdominal segment 3 | late third instar larval stage
neuroblast & larval abdominal segment 4 | late third instar larval stage
neuroblast & larval abdominal segment 5 | late third instar larval stage
neuroblast & larval abdominal segment 6 | late third instar larval stage
neuroblast & larval abdominal segment 7 | late third instar larval stage
Dendrites of Nc mutant C4da neuron clones appear normal at larval stages. However, unlike wild-type, these neurons fail to properly prune their larval dendrites during metamorphosis and most display relatively intact primary and secondary larval dendritic arbors at 18 hours after puparium formation.
Nc homozygous embryos hatch at the normal time, but the larvae develop more slowly than wild-type. These larvae fail to pupariate, but continue to grow for some time after controls pupariate. The resulting giant larvae die at 10-12 days after wild-type larvae pupariate. Unlike wild-type larvae, these larvae are not induced to pupariate early by feeding with ecdysone at the mid-third instar. Nc homozygous larvae fail to exhibit cell death in the larval midgut ,as wild-type larvae do, at end of the third larval instar (assayed by Tunel staining) or in response to feeding with ecdysone at mid-third instar (assayed by acridine orange staining). In Nc homozygous larvae, most of the abdominal neuroblasts in segments A3-A7 that normally die during the late third instar persist.
|Phenotype Manifest In|
|NOT Suppressor of|
|Complementation & Rescue Data|
|Partially rescued by|
|Not rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 3 )|
|Secondary FlyBase IDs|
|References ( 2 )|