Allele Dmel\yki^{Scer\UAS.T:Hsap\MYC}

General Information
Symbol	Dmel\yki^{Scer\UAS.T:Hsap\MYC}	Species	D. melanogaster
Name		FlyBase ID	FBal0239892
Feature type	allele	Associated gene	Dmel\yki

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Zhang et al., 2008) in vitro construct - regulatory fusion (Zhang et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of yki which is tagged at the N-terminal end with six copies of T:Hsap\MYC. (Zhang et al., 2008)
Carried in construct	P{UAS-yki.Myc} (Zhang et al., 2008, Zhang et al., 2008, Ren et al., 2010)
Tagged with	T:Hsap\MYC (Zhang et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	visible, with Scer\GAL4^GMR.PF (Ren et al., 2010)
Phenotype Manifest In
	eye, with Scer\GAL4^GMR.PF (Ren et al., 2010)
Detailed Description
	Statement Reference Expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF] results in an enlarged eye phenotype. (Ren et al., 2010) Expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF] induces little, if any, overgrowth of adult eyes. (Zhang et al., 2008)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, enhanceable by 14-3-3ε^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, enhanceable by 14-3-3ε^j2B10/14-3-3epsilon[+] (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, enhanceable by 14-3-3ζ^12BL/14-3-3zeta[+] (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, enhanceable by 14-3-3ζ^VDRC.cUa, Scer\GAL4^GMR.PF (Ren et al., 2010)
Suppressed by
Statement Reference 14-3-3ε^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, suppressible by 14-3-3ζ^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) 14-3-3ζ^VDRC.cUa, Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, suppressible by 14-3-3ε^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, suppressible by 14-3-3ε^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, suppressible by 14-3-3ζ^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has visible phenotype, suppressible by 14-3-3ζ^{Scer\UAS.T:Ivir\HA1}/14-3-3ε^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, enhanceable by 14-3-3ε^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, enhanceable by 14-3-3ε^j2B10/14-3-3epsilon[+] (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, enhanceable by 14-3-3ζ^12BL/14-3-3zeta[+] (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, enhanceable by 14-3-3ζ^VDRC.cUa, Scer\GAL4^GMR.PF (Ren et al., 2010)
Suppressed by
Statement Reference 14-3-3ε^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, suppressible by 14-3-3ζ^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) 14-3-3ζ^VDRC.cUa, Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, suppressible by 14-3-3ε^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, suppressible by 14-3-3ε^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, suppressible by 14-3-3ζ^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010) Scer\GAL4^GMR.PF, yki^{Scer\UAS.T:Hsap\MYC} has eye phenotype, suppressible by 14-3-3ζ^{Scer\UAS.T:Ivir\HA1}/14-3-3ε^{Scer\UAS.T:Ivir\HA1}, Scer\GAL4^GMR.PF (Ren et al., 2010)
Additional Comments
Genetic Interactions
Statement Reference Co-expression of either 14-3-3ζ[VDRC.cUa] or 14-3-3ε[dsRNA.Scer\UAS] enhances the eye overgrowth phenotype caused by expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF]. The ability of 14-3-3ε[dsRNA.Scer\UAS] to enhance the eye overgrowth phenotype caused by expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF] is significantly suppressed by co-expression of 14-3-3ζ[Scer\UAS.T:Ivir\HA1]. The ability of 14-3-3ζ[VDRC.cUa] to enhance the eye overgrowth phenotype caused by expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF] is significantly suppressed by co-expression of 14-3-3ε[Scer\UAS.T:Ivir\HA1]. The eye overgrowth phenotype caused by expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF] is enhanced by 14-3-3ε[j2B10]/+ and by 14-3-3ζ[12BL]/+. Co-expression of either 14-3-3ε[Scer\UAS.T:Ivir\HA1], 14-3-3ζ[Scer\UAS.T:Ivir\HA1] or both 14-3-3ε[Scer\UAS.T:Ivir\HA1] and 14-3-3ζ[Scer\UAS.T:Ivir\HA1] together suppresses the eye overgrowth phenotype caused by expression of yki[Scer\UAS.T:Hsap\MYC] under the control of Scer\GAL4[GMR.PF]. (Ren et al., 2010)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	yki^{Scer\UAS.T:Hsap\MYC}
Name Synonym
Secondary FlyBase IDs

References ( 3 )
Research paper	Ren et al., 2010, Dev. Biol. 337(2): 303--312 Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms. [FBrf0209792] Zhang et al., 2008, Dev. Cell 14(3): 377--387 The TEAD/TEF family of transcription factor scalloped mediates Hippo signaling in organ size control. [FBrf0204676]
Supplementary material	Zhang et al., 2008, Dev. Cell 14(3): Supplemental Data. [FBrf0208874]

Allele Dmel\ykiScer\UAS.T:Hsap\MYC

Allele Dmel\yki^{Scer\UAS.T:Hsap\MYC}