|Feature type||allele||Associated gene||Dmel\Ilp2|
|Mutagen||in vitro construct - regulatory fusion|
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Controlled Vocabulary Terms
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Carried in construct|
|Phenotype Manifest In|
Male flies expressing Ilp2[Scer\UAS.cBa] under the control of Scer\GAL4[Ilp2.PW] display a strongly reduced survival at starvation.
Mis-expression of Ilp2[Scer\UAS.cBa] in developing wing imaginal discs produces adult flies with a wing size larger than that of control.
Flies expressing Ilp2[Scer\UAS.cBa] under the control of Scer\GAL4[Ilp2.PR] show a significantly reduced repression of growth (assayed by measuring wing area) when shifted from 25[o]C to 29[o]C compared to wild-type flies. Flies expressing Ilp2[Scer\UAS.cBa] under the control of Scer\GAL4[Ilp2.PR] show increased sensitivity to oxidative stress sensitivity.
Overexpression of Ilp2[Scer\UAS.cBa] under the control of Scer\GAL4[arm.PS] results in increased body size and weight. Overexpression of Ilp2[Scer\UAS.cBa] under the control of Scer\GAL4[ppl.PP] causes lethality.
When Ilp2Scer\UAS.cBa is expressed by under the control of Scer\GAL4hs.PB, a proportionate increase in body size is seen. Compared to wild-type body weight and number of ommatidia are increased by 39% and 5% respectively. The wing areas is increased by 21% due to significant increases in cell size and number (9% and 11% respectively).
Ilp2Scer\UAS.cBa, Scer\GAL4ppl.PP has lethal phenotype, suppressible by ImpL2s.Scer\UAS, Scer\GAL4ppl.PP
Ilp2Scer\UAS.cBa, Scer\GAL4sd-SG29.1 has size defective phenotype, suppressible by IdeScer\UAS.cTa, Scer\GAL4sd-SG29.1
Ilp2Scer\UAS.cBa/Ilp2Scer\UAS.cBa, Scer\GAL4hs.PB has increased cell number phenotype, suppressible by InR304
Ilp2Scer\UAS.cBa/Ilp2Scer\UAS.cBa, Scer\GAL4hs.PB has increased cell size phenotype, suppressible by InR304
|Phenotype Manifest In|
Co-expression of Ide[Scer\UAS.cTa] using Scer\GAL4[sd-SG29.1] significantly suppresses the Ilp2[Scer\UAS.cBa]-induced wing-size phenotype.
The increased body weight phenotype resulting from the overexpression of Ilp2[Scer\UAS.cBa] via Scer\GAL4[arm.PS] is dominantly enhanced by ImpL2[Def42]. Overexpression of Ilp2[Scer\UAS.cBa] under the control of Scer\GAL4[arm.PS] causes lethality in ImpL2[Def42]/ImpL2[Def20] mutants. Co-expression of Ilp2[Scer\UAS.cBa] with ImpL2[s.Scer\UAS] under the control of Scer\GAL4[ppl.PP] suppresses the lethality caused by the overexpression of the individual Ilp2[Scer\UAS.cBa] or ImpL2[s.Scer\UAS] transgenes.
|Complementation & Rescue Data|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 7 )|
Saccharomyces cerevisiae UAS construct a of Brogiolo
Saccharomyces cerevisiae UAS construct a of Ikeya
|Secondary FlyBase IDs|
|References ( 9 )|