Expression of Ilp2Scer\UAS.cBa under the control of Scer\GAL4ey.PU suppresses the overgrowth found in Pten117 mutant clones under starvation conditions. Furthermore, expression of Ilp2Scer\UAS.cBa restores the growth of both the tissue surrounding the Pten117 clone and peripheral tissue.
Expression of Ilp2Scer\UAS.cBa in the insulin-producing cells under the control of Scer\GAL4Ilp2.PR rescues the starvation resistance and mobilization of TAGs from abdominal fat body cells seen in itgr[ku] (Itp-r83Aka1091/Itp-r83Aug3) mutant flies to wild type levels. The increase in body weight and stored TAG levels are only partially rescued.
Expression of Ilp2Scer\UAS.cBa in the insulin-producing cells under the control of Scer\GAL4Ilp2.PR partially restores the profile of TAGs and their constituent fatty acids in Itp-r83Aka1091/Itp-r83Aug3 mutants to that of the wild type under starvation.
Co-expression of Ilp2Scer\UAS.cBa with ImpL2s.Scer\UAS under the control of Scer\GAL4ppl.PP suppresses the lethality caused by the overexpression of the individual Ilp2Scer\UAS.cBa or ImpL2s.Scer\UAS transgenes.