FlyBase Allele Report: Dmel\dome[JF01682]

General Information

Symbol

Dmel\dome^JF01682

Species

D. melanogaster

Name

FlyBase ID

FBal0240323

Feature type

allele

Associated gene

Dmel\dome

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01682}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF01682}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF01682

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

dome^JF01682, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Scer\FLP1^ey.PU/dome^JF01682, Scer\GAL4^Act.PU is a suppressor of neoplasia | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\FLP1^ey.PU, Scer\GAL4^Act.PU, dome^JF01682 has viable phenotype

(Chabu and Xu, 2014)

Ras85D^V12.UAS, Scer\FLP1^ey.PU, Scer\GAL4^Act.PU, dome^JF01682 has visible phenotype

(Chabu and Xu, 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\FLP1^ey.PU/dome^JF01682, Scer\GAL4^Act.PU is a suppressor of eye disc | somatic clone | third instar larval stage phenotype of Ras85D^V12.UAS, Scer\GAL4^Act.PU

(Chabu and Xu, 2014)

Other

Statement

Reference

Ras85D^V12.UAS, Scer\FLP1^ey.PU, Scer\GAL4^Act.PU, dome^JF01682 has eye phenotype

(Chabu and Xu, 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of dome^JF01682 suppresses the overgrowth seen in eye-antennal disc clones expressing Ras85D^V12.Scer\UAS under the control of Scer\GAL4^Act.PU. The Ras85D^V12.Scer\UAS, dome^JF01682 clones have reduced mitotic potential compared to Ras85D^V12.Scer\UAS alone. The phenotype is less severe when the clones are generated in the entire eye disc than when the clones are surrounded by wild type cells in mosaic clones, and yields viable adults. The adult flies co-expressing dome^JF01682 have a smaller eye size than those expressing Ras85D^V12.Scer\UAS alone.

(Chabu and Xu, 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28983

y¹ v¹; P{TRiP.JF01682}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

dome^JF01682

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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