|Feature type||allele||Associated gene||Dmel\Miro|
|Also Known As||Mirosd32|
|Allele class||loss of function allele|
What does this section display?
This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).
What does this section not display?
This section does not currently display links that were removed or gene model changes.
Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
|All updates||Click here to see a list of all updates to this record from FB2010_08 and on.|
|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
|Phenotype Manifest In|
Homozygous ventral midline precursor cells do not divide more often than wild-type precursors.
Heterozygous Miro[Sd32] mutants display mitochondrial mislocalisation in neurons.
In the motor neurons of Miro[B682]/Miro[Sd32] larvae, mitochondria are largely absent from neuro-muscular junctions, and are present in reduced numbers in axons, mainly concentrated close to the ventral ganglion. The proportion of motile mitochondria is significantly reduced in these cells and, unlike in wild-type, many stationary mitochondria are not clustered. In addition, the motile mitochondria (both anterograde and retrograde) are significantly smaller than in wild-type.
Gross eye morphology is normal but phototaxis is defective in flies whose eyes are homozygous for Miro[Sd32]. In neurons of Miro[Sd32]/Miro[B682] larvae, mitochondria are retained in the cell bodies and not properly distributed to neuronal processes - most neuromuscular junctions lack mitochondria. Bouton morphology and distribution is abnormal at neuromuscular junctions in Miro[B682]/Miro[Sd32] larvae. In Miro[Sd32]/Miro[B682] larvae, excitatory junction potential evoked by 10Hz stimulation of neuro-muscular junctions (NMJs) starts off normal, but, unlike wild-type, rapidly decays.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to complement|
|Partially rescued by|
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 5 )|
|Secondary FlyBase IDs|
|References ( 6 )|