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General Information
Symbol
Dmel\tkvdsRNA.IR2.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0240399
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference
UAS sequences drive expression of an inverted repeat which targets unspecified sequence in the 5' half of the tkv mRNA.
Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
Expression of tkvdsRNA.IR2.Scer\UAS under the control of Scer\GAL4sd-SG29.1 results in mild expansion of wing vein material.
In pupal retinas tkvIR1.Scer\UAS; tkvIR2.Scer\UAS; Scer\GAL4GMR.PF at around 25 hours APF inter-ommatidial precursor cells fail to maintain stable, adherens junction mediated contacts with each, allowing abberant contacts to form between primary pigment cells in adjacent ommatidia. The affected inter-ommatidial precursor cells often fail to maintain a normal apical profile. In tkvIR2.Scer\UAS; Scer\GAL4sd-SG29.1 adults, have thickened wing veins - with distal regions of L2 and L5 most severely affected..
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Expression of pyd3.dsRNA.Scer\UAS strongly enhances the wing vein defects seen when tkvdsRNA.IR2.Scer\UAS is expressed under the control of Scer\GAL4sd-SG29.1. One copy of pydtex2 strongly enhances the wing vein defects seen when tkvdsRNA.IR2.Scer\UAS is expressed under the control of Scer\GAL4sd-SG29.1.
The frequency of inter-ommatidial pattering defects in tkvIR1.Scer\UAS; tkvIR2.Scer\UAS; Scer\GAL4GMR.PF pupal retinas at 42 hours APF is significantly enhanced by Rho172F/+. This enhancement is not seen with Cdc42unspecified/+, Rac1unspecified/+, Rac2unspecified/+, or Mtlunspecified/+. The wing vein thickening phenotype seen in tkvIR2.Scer\UAS; Scer\GAL4sd-SG29.1 adults is enhanced by Rho172F/+ or shgR69/+, but not by Cdc42unspecified/+, Rac1unspecified/+, Rac2unspecified/+, or Mtlunspecified/+.
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments
dsRNA expressed from this construct used to study the phenotypic consequences of depleting tkv mRNA targeted using a Scer\GAL4 driver.
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
tkvIR2.Scer\UAS
tkvdsRNA.IR2.Scer\UAS
tkvdsRNA.IR2.UAS
Name Synonyms
Secondary FlyBase IDs
    References (3)