FB2025_01 , released February 20, 2025
Allele: Dmel\Hipk4
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General Information
Symbol
Dmel\Hipk4
Species
D. melanogaster
Name
FlyBase ID
FBal0240412
Feature type
allele
Associated gene
Dmel\Hipk
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
FLPase
(Lee et al., 2009)
Progenitor genotype
PBac{WH}Hipkf04609
(Lee et al., 2009)
PBac{WH}Hipkf03158
(Lee et al., 2009)
Cytology
Description

Recombination between the two progenitor insertions has deleted the intervening sequence, resulting in a deletion of 19.9kb of the hipk genomic region, which includes exons 4 to 13.

(Lee et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:560,817..580,867 [+]
Comment:

Recombination between the two progenitor insertions has deleted the intervening sequence, resulting in a deletion of 19.9kb of the Hipk genomic region, which includes exons 4 to 13.

(Lee et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  hematologic cancer
      modeled by hopTum
      (Tettweiler et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Hipk4/HipkBG00855 pharates dissected from pupal cases show reduced eye size, loss of ocelli, and missing ocellar and posterior vertical bristles.

      (Kinsey et al., 2021)

      Lethality occurs prior to the third larval instar.

      hipk3/hipk4 pharate adults show preferential loss in the ventral region of the eye, resulting in a small round eye.

      Homozygous clones in the eye disc result in a loss of photoreceptor cells in the disc.

      (Lee et al., 2009)

      Somatic clones mutant for hipk4 show ectopic veins in the anterior region of the wing blade along wing vein L2, loss of the posterior cross vein and occasional notches in the wing margin.

      (Lee et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      Hipk[+]/Hipk4 is an enhancer of abnormal size | adult stage phenotype of upd1unspecified

      (Tettweiler et al., 2019)

      Hipk3/Hipk4 is an enhancer of visible phenotype of Scer\GAL4ey.PH, fngUAS.cKa

      (Lee et al., 2009)
      Suppressor of
      Statement
      Reference

      Hipk[+]/Hipk4 is a suppressor | partially of melanotic mass phenotype | larval stage phenotype of hopTum

      (Tettweiler et al., 2019)
      NOT Suppressor of
      Statement
      Reference

      Hipk[+]/Hipk4 is a non-suppressor of lethal | heat sensitive phenotype of hopTum

      (Tettweiler et al., 2019)
      Other
      Phenotype Manifest In
      Suppressed by
      NOT suppressed by
      Enhancer of
      Statement
      Reference

      Hipk[+]/Hipk4 is an enhancer of eye phenotype of upd1unspecified

      (Tettweiler et al., 2019)

      Hipk3/Hipk4 is an enhancer of eye phenotype of Scer\GAL4ey.PH, fngUAS.cKa

      (Lee et al., 2009)

      Hipk4 is an enhancer of wing margin phenotype of Scer\GAL4dpp.blk1, fz2UAS.N

      (Lee et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The small eye phenotype caused by expression of fngScer\UAS.cKa under the control of Scer\GAL4ey.PH is enhanced by hipk3/hipk4.

      (Lee et al., 2009)

      Removing one copy of hipk4 in animals expressing fz2Scer\UAS.N in the anteroposterior wing boundary using Scer\GAL4dpp.blk1 enhances the wing notching phenotype, resulting in moderate to severely truncated wings.

      (Lee et al., 2009)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      HipkBG00855/Hipk4 is partially rescued by Scer\GAL4Hipk-BG00855/HipkUAS.cTa.Tag:HA

      (Kinsey et al., 2021)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Allelic series (weakest to strongest): hipk2 < hipkBG00855 < hipk3 < hipk4.

      (Lee et al., 2009)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hipk4
      dhipk4
      (Kinsey et al., 2021)
      hipk4
      (Tettweiler et al., 2019, Blaquiere et al., 2014, Chen and Verheyen, 2012, Lee et al., 2009, Lee et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)