FlyBase Allele Report: Dmel\aux[L78H]

General Information

Symbol

Dmel\aux^L78H

Species

D. melanogaster

Name

FlyBase ID

FBal0240438

Feature type

allele

Associated gene

Dmel\aux

Associated Insertion(s)

Carried in Construct

Also Known As

dAux^L78H

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Kandachar et al., 2008)

Progenitor genotype

Cytology

Description

Amino acid replacement: L78H.

(Kandachar et al., 2008)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:4,221,813..4,221,813 [+]

Nucleotide change:

T4221813A

Amino acid change:

L78H | aux-PA; L78H | aux-PB; L78H | aux-PC; L70H | aux-PD

Reported amino acid change:

L78H

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Kandachar et al., 2008)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage (with aux^W328X)

(Kandachar et al., 2008)

lethal - all die during embryonic stage (with aux^W328X), with aux^{ΔJ.UAS.mRFP(Unk)}

(Kandachar et al., 2008)

male sterile (with aux^I670K)

(Zhou et al., 2011)

some die during embryonic stage (with aux^W328X), with aux^{ΔJ.UAS.mRFP(Unk)}

(Kandachar et al., 2008)

some die during larval stage (with aux^W328X)

(Kandachar et al., 2008)

visible

(Cheli et al., 2010)

Phenotype Manifest In

cystic bulge (with aux^I670K)

(Zhou et al., 2011)

eye

(Cheli et al., 2010)

eye (with aux^I670K)

(Zhou et al., 2011)

eye photoreceptor cell | increased number (with aux^I670K)

(Zhou et al., 2011)

individualization stage spermatid (with aux^I670K)

(Zhou et al., 2011)

ommatidial precursor cluster | somatic clone

(Kandachar et al., 2008)

scutellar bristle | increased number (with aux^I670K)

(Zhou et al., 2011)

sternopleural bristle | increased number (with aux^I670K)

(Zhou et al., 2011)

Detailed Description

Statement

Reference

aux^I670K/aux^L78H adults exhibit rough eyes, with extra photoreceptor cells and occasional extra bristles on the notum, sternopleurum, and scutellum.

aux^I670K/aux^L78H mutant males, when mated to wild-type females, do not produce any embryos that hatch. Spermatids do develop in the testis, however the seminal vesicles are empty in adult male flies. The morphology of the testis hub cells appear normal in these animals. The number of germ cells is comparable to wild-type testes. Spermatid individualisation is disrupted in mutants, and migration of the investment cone along spermatid cysts does not occur normally.

(Zhou et al., 2011)

Homozygous clones in the eye disc show increased numbers of disorganised elav-positive neuronal cells, instead of the organised clusters containing 8 elav-positive per cluster that are seen in wild type.

aux^L78H/aux^W328X animals expressing aux^{ΔJ.Scer\UAS.T:Disc\RFP-mRFP} under the control of Scer\GAL4^Act5C.PI die before the larval stage.

(Kandachar et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

aux^L78H

(Cheli et al., 2010)

dAux^L78H

(Zhou et al., 2011, Kandachar et al., 2008)

daux^L78H

(Zhang et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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