FB2025_01 , released February 20, 2025
Allele: Dmel\auxF956X
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General Information
Symbol
Dmel\auxF956X
Species
D. melanogaster
Name
FlyBase ID
FBal0240439
Feature type
allele
Associated gene
Dmel\aux
Associated Insertion(s)
Carried in Construct
Also Known As
auxF956*
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Kandachar et al., 2008)
Progenitor genotype
Cytology
Description

Amino acid replacement: F956term.

(Kandachar et al., 2008)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
MNV
3R:4,226,101..4,226,102 [+]
Nucleotide change:

TTC4226100TRR

Amino acid change:

S957term | aux-PA; S957term | aux-PB; S945term | aux-PC; S949term | aux-PD

Reported amino acid change:

F956term

Comment:

The reported Phe to Stop amino acid change (TTC to TAA, TAG or TGA) requires nucleotide changes at two positions of the codon. The site of the nucleotide substitution in the mutant was inferred by FlyBase based on the reported amino acid change. It has been annotated as a TAA stop codon, though the identity of the stop codon was not reported.

(Kandachar et al., 2008)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease 19A
      CEC with auxRG.HA
      (Jacquemyn et al., 2023)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous clones in the eye disc show increased numbers of disorganised elav-positive neuronal cells, instead of the organised clusters containing 8 elav-positive per cluster that are seen in wild type.

      (Kandachar et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      auxF956*
      (Zhao et al., 2022, Banks et al., 2011)
      auxF956X
      (Banks et al., 2011)
      dAuxF956*
      (Kandachar et al., 2008)
      dAuxF956x
      (Jacquemyn et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)