|Feature type||allele||Associated gene||Dmel\aux|
|Also Known As||dAuxG257E|
|Map ( GBrowse )|
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|Nature of the Allele|
|Mutations Mapped to the Genome|
|Associated Sequence Data|
|Nature of the lesion|
Amino acid replacement: G257E.
|Phenotype Manifest In|
aux[I670K]/aux[G257E] adults exhibit rough eyes, with extra photoreceptor cells and occasional extra bristles on the notum, sternopleurum, and scutellum. aux[I670K]/aux[G257E] mutant males, when mated to wild-type females, do not produce any embryos that hatch. Spermatids do develop in the testis, however the seminal vesicles are empty in adult male flies. The morphology of the testis hub cells appear normal in these animals. A slightly reduced number of germ cells is observed compared to wild-type testes. Cytokinesis is mostly normal in these animals. In 5% of spermatids examined, an enlarged mitochondrial derivative associated with two nuclei is observed. Spermatid individualisation is disrupted in mutants, and migration of the investment cone along spermatid cysts does not occur normally.
|Phenotype Manifest In|
|Complementation & Rescue Data|
|Fails to rescue|
Expression of aux[FL.βTub85D.T:Disc\RFP-mRFP] in aux[I670K]/aux[G257E] mutants rescues male sterility. The rough eye and supernumerary bristle phenotypes are not rescued. Expression of aux[ΔK.βTub85D.T:Disc\RFP-mRFP] in aux[I670K]/aux[G257E] mutants rescues male sterility. Expression of aux[CJ.βTub85D.T:Disc\RFP-mRFP] in aux[I670K]/aux[G257E] mutants rescues male sterility. Expression of aux[ΔJ.βTub85D.T:Disc\RFP-mRFP] in aux[I670K]/aux[G257E] mutants fails to rescue male sterility. Expression of aux[ΔC.βTub85D.T:Disc\RFP-mRFP] in aux[I670K]/aux[G257E] mutants fails to rescue male sterility.
|Stocks ( 0 )|
|Notes on Origin|
|External Crossreferences & Linkouts|
|Synonyms & Secondary IDs ( 2 )|
|Secondary FlyBase IDs|
|References ( 3 )|