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General Information
Symbol
Zzzz\CAGQ92.GMR.Tag:FLAG
Species
a. artificial
Name
FlyBase ID
FBal0240457
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
GMR-FlagQ92
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

GMR regulatory sequences drive expression of a 92 residue polyglutamine repeat, which is tagged with Tag:FLAG.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Flies carrying Zzzz\CAGQ92.GMR.T:Zzzz\FLAG show eye degeneration phenotypes, including loss of pigment and rough eyes. Inclusion bodies are seen in the region posterior to the morphogenetic furrow in the eye disc.

Flies carrying Zzzz\CAGQ92.GMR.T:Zzzz\FLAG show degeneration of the eye.

Expression of Zzzz\CAGQ92.GMR.T:Zzzz\FLAG induces eye degeneration.

Flies carrying Zzzz\CAGQ92.GMR.T:Zzzz\FLAG have a rough eye phenotype, and reduced pigmentation in the eye. The internal structure of the compound eye is severely disrupted, with most eye cells being shrunken or flattened.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expression of Hsap\CRYABScer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PS effectively suppresses the mutant eye phenotypes of Zzzz\CAGQ92.GMR.T:Zzzz\FLAG flies, especially the loss of pigment phenotype. The formation of inclusion bodies in the eye disc is also suppressed in these animals.

Expression of Mmmm\VCPScer\UAS.cKa under the control of Scer\GAL4GMR.PS suppresses the eye degeneration caused by Zzzz\CAGQ92.GMR.T:Zzzz\FLAG.

Co-expression of Scer\GAL4GMR.PS>Hsap\VCPT761E.Scer\UAS with Zzzz\CAGQ92.GMR.T:Zzzz\FLAG enhances the Zzzz\CAGQ92.GMR.T:Zzzz\FLAG-induced eye degeneration.

Co-expression of Scer\GAL4GMR.PS>Hsap\VCPR155H.Scer\UAS with Zzzz\CAGQ92.GMR.T:Zzzz\FLAG enhances the Zzzz\CAGQ92.GMR.T:Zzzz\FLAG-induced eye degeneration.

Co-expression of Scer\GAL4GMR.PS>Hsap\VCPR155P.Scer\UAS with Zzzz\CAGQ92.GMR.T:Zzzz\FLAG enhances the Zzzz\CAGQ92.GMR.T:Zzzz\FLAG-induced eye degeneration.

Co-expression of Scer\GAL4GMR.PS>Hsap\VCPA232E.Scer\UAS with Zzzz\CAGQ92.GMR.T:Zzzz\FLAG enhances the Zzzz\CAGQ92.GMR.T:Zzzz\FLAG-induced eye degeneration.

Co-expression of Scer\GAL4GMR.PS>Hsap\VCPScer\UAS.cMa with Zzzz\CAGQ92.GMR.T:Zzzz\FLAG mitigates the Zzzz\CAGQ92.GMR.T:Zzzz\FLAG-induced eye degeneration.

Expression of TER94Scer\UAS.cHa under the control of Scer\GAL4GMR.PS enhances the rough eye phenotypes caused by Zzzz\CAGQ92.GMR.T:Zzzz\FLAG.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Zzzz\CAGQ92.GMR.T:Zzzz\FLAG
Zzzz\CAGQ92.GMR.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (4)