Allele Dsim\Nmy¹⁴²⁷

General Information
Symbol	Dsim\Nmy¹⁴²⁷	Species	D. simulans
Name		FlyBase ID	FBal0240516
Feature type	allele	Associated gene	Dsim\Nmy
Also Known As	nmy, SSR12-2-7

Allele class	loss of function allele
Mutagen	natural population
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Tao et al., 2007)
Mutagen	natural population (Tao et al., 2007)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Loss of one of the inverted repeats that is present in the wild-type Dsim\Nmy locus, and the loss of most of the sequence located between the inverted repeats, except for a 93bp element in reverse orientation. (Tao et al., 2007)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	elongation stage spermatid (Tao et al., 2007) individualization stage spermatid (Tao et al., 2007) onion stage spermatid (Tao et al., 2007)
Detailed Description
	Statement Reference Dsim\Nmy[1427] males show sex ratio distortion; the progeny of such males show a female-biased sex ratio. The expressivity of the sex ratio distortion is inversely correlated to the temperature; at 18[o]C, the sex ratio of the progeny can reach as high as 93%, whereas at 25[o]C, the sex ratio decreases to approximately 60%. Only the temperature at which the males are reared has an effect on the sex ratio distortion. The age of the males also has a much smaller, but also significant, effect on the sex ratio distortion. Dsim\Nmy[1427] males show abnormalities in various stages of spermatogenesis. The mutant spermatid nuclei start to accumulate nucleoplasmic vacuoles at the late onion stage. At the early elongation stage, some mutant spermatid nuclei have very pronounced nucleoplasmic vacuoles, although the alignment of rows of microtubules along the fenestrated portion of the nuclear membrane appears normal. Later, in the post-elongation period, nuclear condensation appears disrupted, and rupture of the nuclear membrane is sometimes seen. During individualisation, the nucleoplasmic vacuoles within abnormal mutant spermatids are squeezed into the tail region, apparently causing physical difficulty for the cystic bulge to pass through. These abnormal tails remain in the syncytium, which other tails are individualised and separated. (Tao et al., 2007)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference Dsim\Dox[Δ105] Dsim\Nmy[1427] males do not show sex ratio distortion (the sex ratio of the progeny of double mutant males raised at 16[o]C is 54%). All stages of spermatid maturation appear to be normal in these double mutant males. (Tao et al., 2007)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Dsim\Nmy[1427] is segregating in the D.simulans sim2 strain with a frequency of 6.1% (Tao et al., 2007)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Dsim\Nmy¹⁴²⁷ nmy (Tao et al., 2007, Tao et al., 2007) nmy^sim1427 (Tao et al., 2007) SSR12-2-7 (Tao et al., 2007, Tao et al., 2007)
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Tao et al., 2007, PLoS Biol. 5(11): e293 A sex-ratio meiotic drive system in Drosophila simulans. II: An X-linked distorter. [FBrf0202812] Tao et al., 2007, PLoS Biol. 5(11): e292 A sex-ratio meiotic drive system in Drosophila simulans. I: An autosomal suppressor. [FBrf0202673]

Allele Dsim\Nmy1427

Allele Dsim\Nmy¹⁴²⁷