FB2025_01 , released February 20, 2025
Allele: Dmel\Sec6EY10058
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General Information
Symbol
Dmel\Sec6EY10058
Species
D. melanogaster
Name
FlyBase ID
FBal0240525
Feature type
allele
Associated gene
Dmel\Sec6
Associated Insertion(s)
P{EPgy2}Sec6EY10058
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
    Nature of the Allele
    Allele class

    hypomorphic allele - molecular evidence

    (Zhou et al., 2007)
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{EPgy2}Sec6EY10058
    Cytology
    Description

    Sec6 transcript levels are down-regulated.

    (Zhou et al., 2007)
    Allele components
    Component
    Use(s)
    Inserted element
    P{EPgy2}
    Regulatory region(s)
    UASp
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  amyotrophic lateral sclerosis type 8
        modeled by Vap33P58S.UAS.Tag:FLAG
        (Sanhueza et al., 2015)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Mutant embryos cultured under hypoxic conditions (5% O[[2]]) show increased eclosion compared to controls raised under the same conditions.

        (Zhou et al., 2007)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        Comments
        Comments

        Precise excision of the insertion reverts the phenotype of increased survival under hypoxic conditions.

        (Zhou et al., 2007)
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Sec6EY10058
        sec6EY10058
        Name Synonyms
        Secondary FlyBase IDs
          References (2)