FB2021_06, released December 14, 2021

Allele: Dmel\vgUAS.cKa

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General Information
Symbol
Dmel\vgUAS.cKa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Kim
FlyBase ID
FBal0240533
Feature type
allele
Associated gene
Dmel\vg
Associated Insertion(s)
Carried in Construct
P{UAS-vg.K}
Also Known As
UAS-vg, UASvg, UAS-vg73
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
in vitro construct - regulatory fusion
(MacKay et al., 2003, Kim et al., 1996)
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
       
      Progenitor genotype
      Carried in construct
      P{UAS-vg.K}
      Cytology
      Nature of the lesion
      Statement
      Reference

      Expression of vg cDNA is governed by UAS regulatory sequences.

      (Kim et al., 1996)
      Allele components
      Product class / Tool use(s)
      Regulatory region(s)
      UAS
      Encoded product / tool
      vg
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  cancer
      modeled by dlg1HMS01954
      (Bunker et al., 2015)
      exacerbates  diffuse midline glioma, H3 K27M-mutant
      modeled by His3.3AK27M.UASp
      (Ahmad and Henikoff, 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class

      abnormal size, with Scer\GAL4ap-md544

      (Baena-Lopez and Garcia-Bellido, 2006)

      abnormal size, with Scer\GAL4Dll-md23

      (Baena-Lopez and Garcia-Bellido, 2006)

      abnormal size, with Scer\GAL4nub.PK

      (Baena-Lopez and Garcia-Bellido, 2006)

      abnormal size, with Scer\GAL4salm.EPv

      (Baena-Lopez and Garcia-Bellido, 2006)

      abnormal size | larval stage | somatic clone, with Scer\GAL4αTub84B.PL

      (Baena-Lopez and Garcia-Bellido, 2006)

      decreased occurrence of cell division | cell autonomous | larval stage, with Scer\GAL4Dll-md23

      (Baena-Lopez and Garcia-Bellido, 2006)

      decreased occurrence of cell division | cell autonomous | larval stage, with Scer\GAL4ptc-559.1

      (Baena-Lopez and Garcia-Bellido, 2006)

      decreased occurrence of cell division | cell non-autonomous | larval stage, with Scer\GAL4Dll-md23

      (Baena-Lopez and Garcia-Bellido, 2006)

      decreased occurrence of cell division | cell non-autonomous | larval stage, with Scer\GAL4ptc-559.1

      (Baena-Lopez and Garcia-Bellido, 2006)

      increased occurrence of cell division | larval stage | somatic clone, with Scer\GAL4αTub84B.PL

      (Baena-Lopez and Garcia-Bellido, 2006)

      neoplasia | adult stage | female, with Scer\GAL4C587

      (Li et al., 2015)

      visible, with Scer\GAL4dpp.blk1

      (Simmonds et al., 1998)

      visible, with Scer\GAL4sca-C253

      (Baena-Lopez and Garcia-Bellido, 2003)

      visible | homeotic, with Scer\GAL4bi-md653

      (Mohit et al., 2006, Prasad et al., 2003)

      visible | homeotic, with Scer\GAL4Dll-md23

      (Weatherbee et al., 1998)

      visible | homeotic, with Scer\GAL4Ubx-lac1-Gal4

      (Pallavi et al., 2006)
      Phenotype Manifest In

      direct flight muscle cell, with Scer\GAL41151

      (Sudarsan et al., 2001)

      eye, with Scer\GAL4dpp.blk1

      (Simmonds et al., 1998, Kim et al., 1996)

      eye disc, with Scer\GAL4T113

      (Go et al., 1998)

      germarium, with Scer\GAL4C587

      (Li et al., 2015)

      haltere, with Scer\GAL4bi-md653

      (Mohit et al., 2006, Prasad et al., 2003)

      haltere, with Scer\GAL4Ubx-lac1-Gal4

      (Pallavi et al., 2006)

      head, with Scer\GAL4c409

      (Kim et al., 1996)

      mesothoracic leg, with Scer\GAL4Dll-md23

      (Weatherbee et al., 1998)

      mesothoracic leg, with Scer\GAL4upd1-E132

      (Kim et al., 1996)

      mesothoracic tergum & chaeta | supernumerary, with Scer\GAL4sca-C253

      (Baena-Lopez and Garcia-Bellido, 2003)

      metathoracic leg, with Scer\GAL4Dll-md23

      (Weatherbee et al., 1998)

      muscle cell of basalar muscle 51, with Scer\GAL41151

      (Sudarsan et al., 2001)

      second segment of antenna, with Scer\GAL4upd1-E132

      (Kim et al., 1996)

      tergopleural muscle cell, with Scer\GAL41151

      (Sudarsan et al., 2001)

      third segment of antenna, with Scer\GAL4upd1-E132

      (Kim et al., 1996)

      thorax, with Scer\GAL4pnr-MD237

      (Baena-Lopez and Garcia-Bellido, 2003)

      wing, with Scer\GAL4ap-md544

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing, with Scer\GAL4c409

      (Kim et al., 1996)

      wing, with Scer\GAL4Dll-md23

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing, with Scer\GAL4dpp.blk1

      (Simmonds et al., 1998, Kim et al., 1996)

      wing, with Scer\GAL4nub.PK

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing, with Scer\GAL4salm.EPv

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing, with Scer\GAL4upd1-E132

      (Kim et al., 1996)

      wing | ectopic, with Scer\GAL4bi-md653

      (Prasad et al., 2003)

      wing disc, with Scer\GAL4A9

      (Go et al., 1998)

      wing disc, with Scer\GAL4c719a

      (Go et al., 1998)

      wing disc, with Scer\GAL4Dll-md23

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing disc, with Scer\GAL4dpp.blk1

      (Varadarajan and VijayRaghavan, 1999)

      wing disc, with Scer\GAL4ptc-559.1

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing disc, with Scer\GAL4T113

      (Go et al., 1998)

      wing disc | somatic clone, with Scer\GAL4Act5C.PI

      (Adachi-Yamada and O'Connor, 2002, Liu et al., 2000)

      wing disc | somatic clone, with Scer\GAL4αTub84B.PL

      (Baena-Lopez and Garcia-Bellido, 2006)

      wing hair, with Scer\GAL4bi-md653

      (Mohit et al., 2006)

      wing margin bristle, with Scer\GAL4bi-md653

      (Mohit et al., 2006)

      wing margin bristle | ectopic, with Scer\GAL4Ubx-lac1-Gal4

      (Pallavi et al., 2006)
      Detailed Description
      Statement
      Reference

      The expression of vgScer\UAS.cKa under the control of Scer\GAL4Bx-MS1096 does not to any changes in the size of third instar larval wing discs, as compared to controls.

      (Bunker et al., 2015)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4C587 (keeping flies at low temperature to minimize the GAL4 activity during development) results in tumorous female germaria.

      (Li et al., 2015)

      Mutant wing disc clones expressing vgScer\UAS.cKa under the control of Scer\GAL4tub.PU grow well and do not show neoplastic transformation.

      (Khan et al., 2013)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4salm-EPv, Scer\GAL4nub.PK, Scer\GAL4ap-md544 or Scer\GAL4Dll-md23 results in a reduction in adult wing size in both an autonomous and nonautonomous manner. Cell size is not significantly different from wild type at either larval or adult stages. The most prominent reduction in size is visible along the proximal-distal axis of growth.

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4ptc-559.1 or Scer\GAL4Dll-md23 autonomously reduces cell proliferation (as judged by BrdU, mus209 or phospho-His3 expression) in the prospective wing blade of the wing disc, while autonomously and non-autonomously increasing proliferation in the prospective wing hinge. vg-expressing cells in the wing hinge results in tubular outgrowths.

      The area of cell clones expressing vgScer\UAS.cKa under the control of Scer\GAL4αTub84B.PL (generated using the MARCM technique) increases proportionally with the distance to the dorsal-ventral boundary of the wing disc in a continuous manner. This same trend is detected with their associated twin clones, suggesting that differences in vg expression between neighboring cells drives cell proliferation autonomously and non-autonomously.

      In wing discs expressing vgScer\UAS.cKa under the control of Scer\GAL4Dll-md23, mitoses and proliferating cells are preferentially located at the juxtaposition of mutant and wild type cells.

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4ap-md544, Scer\GAL4en-e16E, Scer\GAL4Dll-md23 or Scer\GAL4salm-EPv accelerates the G1-S phase transition.

      Cell clones expressing vgScer\UAS.cKa under the control of Scer\GAL4αTub84B.PL (generated using the MARCM technique) have a significantly shorter doubling time (higher rate of proliferation) in the prospective wing hinge of the wing disc compared to controls or vg-expressing clones in the prospective wing blade.

      (Baena-Lopez and Garcia-Bellido, 2006)

      Clones expressing vgScer\UAS.cKa under the control of Scer\GAL4αTub84B.PL show normal rates of survival in the wing disc.

      (Janody and Treisman, 2006)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4bi-md653 leads to the appearance of wing-like bristles and trichomes on the haltere.

      (Mohit et al., 2006)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4Ubx-lac1-Gal4 causes a high degree of haltere-to-wing transformation as the capitellum of the halteres produce many wing margin-type bristles.

      (Pallavi et al., 2006)

      Expression of vgScer\UAS.cKa under the regulation of Scer\GAL4ey.PB results in ectopic wings in the eye field with wing hair but not wing margins.

      (Katsuyama et al., 2005)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4pnr-MD237 results in defects in thorax closure. Expression of vgScer\UAS.cKa under the control of Scer\GAL4sca-C253 results in duplications of chaetae in the notum.

      (Baena-Lopez and Garcia-Bellido, 2003)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4bi-md653 results in a high degree of haltere to wing transformations.

      (Prasad et al., 2003)

      When vgScer\UAS.cKa clones are made in the wing disc (driven by Scer\GAL4Act5C.PI) produces clones with a rounded appearance.

      (Adachi-Yamada and O'Connor, 2002)

      Clones in the wing disc expressing vgScer\UAS.cKa under the control of Scer\GAL4Act5C.PP tend to sort out from the disc.

      (Wu and Cohen, 2002)

      vgScer\UAS.cKa; Scer\GAL41151 flies have defective direct flight muscles. In particular muscles 51 and 52 are always missing. In contrast, the indirect flight muscles develop normally (9/10 examined).

      (Sudarsan et al., 2001)

      When vgScer\UAS.cKa is over-expressed in clones in the wing disc, driven by Scer\GAL4Act5C.PI, clones that are in the wing hinge region tend to be somewhat larger than control clones. In contrast, clones that are nearer the dorsal-ventral boundary the wing pouch are often much smaller than control clones. the average size of these clones increases withy distance from the dorsal-ventral border. vgScer\UAS.cKa overexpression clones in the wing disc are more rounded and have smoother borders than control clones. Within the wing region of the disc, the influence on clone shape is graded: clone that are near the dorsal-ventral wing border generally continue to have irregular shapes, while clones that are far from the border are more circular.

      (Liu et al., 2000)

      The wing disc is overgrown, especially in regions corresponding to the presumptive wing blade, in animals expressing vgScer\UAS.cKa under the control of Scer\GAL4dpp.blk1.

      (Varadarajan and VijayRaghavan, 1999)

      The dorsal side of the wing pouch is reduced in size in larvae expressing vgScer\UAS.cKa under the control of Scer\GAL4A9. Larvae expressing vgScer\UAS.cKa under the control of Scer\GAL4c719a or Scer\GAL4T113 have small wing discs. Larvae expressing vgScer\UAS.cKa under the control of Scer\GAL4T113 have enlarged eye discs.

      (Go et al., 1998)

      Flies expressing vgScer\UAS.cKa under the control of Scer\GAL4dpp.blk1 show massive outgrowth of wing tissue from the eye. Flies expressing vgScer\UAS.cKa under the control of Scer\GAL4dpp.blk1 at 29oC show a slight reduction in wing size.

      (Simmonds et al., 1998)

      Flies expressing vgScer\UAS.cKa under the control of Scer\GAL4Dll-md23 show transformation of the mesothoracic leg to wing. The transformed structure may contain wing margin bristles and hairs in the "blade" region of the structure are also of wing identity. These flies also show transformation of the metathoracic leg to haltere, the transformed structure having hair morphology and density similar to that found on the haltere. The structure may also contain capitellar sensillae.

      (Weatherbee et al., 1998)

      When expression is governed by Scer\GAL4dpp.blk1, wing-like outgrowths form in the ventral portion of the eye. When expression is governed by Scer\GAL4E132, wing-like growths form in the second leg, from the base of the tibia, and from the antenna (segments 2 and 3). When expression is governed by Scer\GAL4c409, outgrowths from the head capsule show wing-like hairs. Adult wings of various Scer\GAL4-driver vgScer\UAS.cKa combinations are disorganized, small and blistered/ballooned.

      (Kim et al., 1996)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Suppressed by
      Enhancer of
      Suppressor of
      Other
      Phenotype Manifest In
      Enhanced by
      Suppressed by
      Statement
      Reference

      Scer\GAL4C587, vgUAS.cKa has germarium phenotype, suppressible | partially by ykiUAS.cHa/Scer\GAL4C587

      (Li et al., 2015)

      Scer\GAL4C587, vgUAS.cKa has germarium phenotype, suppressible | partially by Scer\GAL4C587/TgiHMS00981

      (Li et al., 2015)

      Scer\GAL4Tub.PU, l(2)gl4, vgUAS.cKa has wing disc | proximal | somatic clone phenotype, suppressible | partially by ykiUAS.cHa/Scer\GAL4Tub.PU

      (Khan et al., 2013)

      Scer\GAL4unspecified, vgScer\UAS.cKa/vgUAS.cKa has wing phenotype, suppressible | partially by Df(3L)H99

      (Baena-Lopez and Garcia-Bellido, 2006)

      Scer\GAL4unspecified, vgScer\UAS.cKa/vgUAS.cKa has wing phenotype, suppressible | partially by pucUAS.cMa/BacA\p35UAS.cHa, Scer\GAL4unspecified

      (Baena-Lopez and Garcia-Bellido, 2006)

      Scer\GAL4A9, vgScer\UAS.cKa/vgUAS.cKa has wing disc phenotype, suppressible by Scer\GAL4A9/wgUAS.cLa

      (Go et al., 1998)

      Scer\GAL4A9, vgScer\UAS.cKa/vgUAS.cKa has wing disc | larval stage phenotype, suppressible by Scer\GAL4A9/wgUAS.cLa

      (Go et al., 1998)

      Scer\GAL4dpp.blk1, vgScer\UAS.cKa/vgUAS.cKa has wing | ectopic phenotype, suppressible by sd58d

      (Simmonds et al., 1998)

      Scer\GAL4dpp.blk1, vgScer\UAS.cKa/vgUAS.cKa has eye phenotype, suppressible by sd58d

      (Simmonds et al., 1998)

      Scer\GAL4dpp.blk1, vgScer\UAS.cKa/vgUAS.cKa has eye phenotype, suppressible | partially by sdUAS.cSa/Scer\GAL4dpp.blk1

      (Simmonds et al., 1998)

      Scer\GAL4dpp.blk1, vgScer\UAS.cKa/vgUAS.cKa has wing | ectopic phenotype, suppressible | partially by sdUAS.cSa/Scer\GAL4dpp.blk1

      (Simmonds et al., 1998)
      NOT suppressed by
      Statement
      Reference

      Scer\GAL4Tub.PU, l(2)gl4, vgUAS.cKa has wing disc | distal | somatic clone phenotype, non-suppressible by ykiUAS.cHa/Scer\GAL4Tub.PU

      (Khan et al., 2013)
      Enhancer of
      Suppressor of
      Statement
      Reference

      Scer\GAL4Bx-MS1096/vgUAS.cKa is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4Bx-MS1096, dlg1HMS01954

      (Bunker et al., 2015)

      Scer\GAL4Tub.PU/vgUAS.cKa is a suppressor of wing disc | somatic clone phenotype of ykiB5

      (Wu et al., 2008)

      vgScer\UAS.cKa, vgUAS.cKa, Scer\GAL4vg.boundary is a suppressor of wing phenotype of Scer\GAL4vg.boundary, sdΔ200.UAS, sd58d

      (Chow et al., 2004)

      vgScer\UAS.cKa, vgUAS.cKa, Scer\GAL4vg.boundary is a suppressor of wing phenotype of Scer\GAL4vg.boundary, sd58d, sdUAS.cSa

      (Chow et al., 2004)

      vgScer\UAS.cKa, vgUAS.cKa, Scer\GAL4vg.boundary is a suppressor of wing phenotype of Scer\GAL4vg.boundary, sdETX4, sdUAS.cSa

      (Chow et al., 2004)

      vgScer\UAS.cKa, vgUAS.cKa, Scer\GAL4vg.boundary is a suppressor of wing phenotype of Scer\GAL4vg.boundary, sdΔ200.UAS, sdETX4

      (Chow et al., 2004)

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, vgUAS.cKa is a suppressor of wing phenotype of Su(H)8/Su(H)2

      (Klein and Martinez Arias, 1998)

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, vgUAS.cKa is a suppressor of wing phenotype of apUGO35

      (Klein and Martinez Arias, 1998)

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, vgUAS.cKa is a suppressor of wing phenotype of wgl-16/wgl-17

      (Klein and Martinez Arias, 1998)

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, vgUAS.cKa is a suppressor of wing phenotype of SerCS94/SerRX106

      (Klein and Martinez Arias, 1998)

      Scer\GAL4ptc-559.1, vgScer\UAS.cKa, vgUAS.cKa is a suppressor of wing phenotype of Su(H)8/Su(H)2

      (Klein and Martinez Arias, 1998)

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, vgUAS.cKa is a suppressor | partially of wing phenotype of Scer\GAL4dpp.blk1, sdUAS.cSa

      (Simmonds et al., 1998)
      NOT Suppressor of
      Statement
      Reference

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, SerUAS.cSa, vgUAS.cKa is a non-suppressor of wing disc phenotype of Su(H)8/Su(H)2

      (Klein et al., 2000)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The co-expression of vgScer\UAS.cKa suppresses the tumor phenotype and tissue disorganization resulting from the expression of dlg1HMS01954 under the control of Scer\GAL4Bx-MS1096.

      (Bunker et al., 2015)

      The tumorous germaria phenotype induced by Scer\GAL4C587-driven expression of vgScer\UAS.cKa is partially rescued by co-expression of either ykiScer\UAS.cHa or TgiHMS00981.

      (Li et al., 2015)

      Distal wing disc clones expressing vgScer\UAS.cKa under the control of Scer\GAL4tub.PU in a l(2)gl4 mutant background show rapid elimination and are rarely recovered. Proximal clones are more often recovered but also undergo cell death and basal extrusion. No neoplastic transformation is seen.

      Expression of ykiScer\UAS.cHa does not suppress the poor recovery rate of distal wing clones expressing vgScer\UAS.cKa under the control of Scer\GAL4tub.PU in a l(2)gl4 mutant background. Extensive cell death is still seen. Survival of proximal clones is somewhat improved, but unlike in l(2)gl4 mutant clones alone, neoplastic transformation is still not observed until day four of clone induction and the clones display dense cell packing and compact nuclear morphology.

      (Khan et al., 2013)

      Homozygous ykiB5 clones which are also expressing vgScer\UAS.cKa under the control of Scer\GAL4tub.PU are readily recovered in the wing blade.

      (Wu et al., 2008)

      Inhibition of cell death, by using a Df(3L)H99 background, only slightly rescues the wing growth defects seen in vgScer\UAS.cKa, Scer\GAL4unspecified flies.

      Cell clones expressing vgScer\UAS.cKa under the control of Scer\GAL4αTub84B.PL that are also mutant for fz15 and fz2C1 (generated using the MARCM technique) are present in the wing disc 48 hours after heat-shock, with increased clone size further away from the dorsal-ventral boundary. However, at 72 hours after heat shock these mutant clones disappear as a result of cell death. Nonautonomous effects on growth and patterning are also seen in these mutant wing discs.

      (Baena-Lopez and Garcia-Bellido, 2006)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4αTub84B.PL in cpa43D mutant clones leads to the extrusion of the clones from all regions of the wing disc, rather than from just the wing blade primordium.

      (Janody and Treisman, 2006)

      Coexpression of dppScer\UAS.cFa and vgScer\UAS.cKa, both under the control of Scer\GAL4bi-md653, leads to an enhancement of the haltere-to-wing transformation seen when either transgene is expressed alone. Almost all haltere cells are transformed to wing-type cells as seen by the large number of bristles and trichomes. The phenotype is fully penetrant in pharate adults and flies expressing both transgenes are lethal at the pharate adult stage.

      (Mohit et al., 2006)

      The defective wing phenotypes seen when sdScer\UAS.cSa or sdΔ200.Scer\UAS are expressed under control of Scer\GAL4vg.boundary in sdETX4 and sd58d mutants is alleviated when vgScer\UAS.cKa is overexpressed.

      (Chow et al., 2004)

      Expression of vgScer\UAS.cKa under the control of Scer\GAL4bi-md653 in a Ubxunspecified/+ background results in enhanced transformation of the haltere to wing.

      (Prasad et al., 2003)

      The wing pouch phenotype seen in larvae expressing vgScer\UAS.cKa under the control of Scer\GAL4A9 is significantly rescued if the larvae are also carrying wgScer\UAS.cLa. Larvae expressing both NICN.Scer\UAS and vgScer\UAS.cKa under the control of Scer\GAL4T113 show striking overgrowth of the eye discs. Other imaginal discs also show overgrowth. This overgrowth phenotype is also seen if the Scer\GAL4dpp.blk1 driver is used instead of Scer\GAL4T113.

      (Go et al., 1998)

      Scer\GAL4dpp.blk1-mediated expression in apUGO35 rescues loss of wing phenotype. Mediated expression in SerCS94/SerRX106 flies substantially rescues the wing blade phenotype. Mediated expression in wgl-16/wgl-17 flies restores the wing. Scer\GAL4dpp.blk1-mediated or Scer\GAL4ptc-559.1-mediated expression substantially rescues the wing blade phenotype of Su(H)2/Su(H)8 flies. Scer\GAL4dpp.blk1-mediated co-expression of vgScer\UAS.cKa and SerScer\UAS.cSa leads to significant induction of an ectopic wing margin in vg83b27-R mutants.

      (Klein and Martinez Arias, 1998)

      The overgrowth of wing tissue in the eye seen in flies expressing vgScer\UAS.cKa under the control of Scer\GAL4dpp.blk1 is partially suppressed if the flies are heterozygous for sd58d and completely suppressed if the flies are hemizygous for sd58d. The phenotype is also partially suppressed if the flies are also coexpressing sdScer\UAS.cSa. Partially suppresses the loss of wing tissue phenotype seen in flies expressing sdScer\UAS.cSa under the control of Scer\GAL4dpp.blk1 at 29oC.

      (Simmonds et al., 1998)

      Restores wing outgrowth to ap- flies. In a mwh mutant background all Scer\GAL4-driver vgScer\UAS.cKa induced outgrowths show a mwh tufted phenotype.

      (Kim et al., 1996)
      Xenogenetic Interactions
      Statement
      Reference

      Inhibition of cell death, through co-expression of BacA\p35Scer\UAS.cHa and pucScer\UAS.cMa under the control of Scer\GAL4unspecified, only slightly rescues the wing growth defects seen in vgScer\UAS.cKa, Scer\GAL4unspecified flies.

      (Baena-Lopez and Garcia-Bellido, 2006)
      Complementation and Rescue Data
      Rescues

      vgScer\UAS.cKa, Scer\GAL4dpp.blk1, vgUAS.cKa rescues vg83b27-R

      (Klein and Martinez Arias, 1998)
      Partially rescues

      Scer\GAL4N23, vgScer\UAS.cKa, vgUAS.cKa partially rescues vg1

      (Prasad et al., 2003)
      Comments

      vg1/vg1 animals expressing vgScer\UAS.cKa under the control of Scer\GAL4N23 show partial rescue of the wing phenotype, but the rescued wing blades do not have margin bristles.

      (Prasad et al., 2003)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      vgScer\UAS.cKa
      vgScer\UAS.cMa
      vgUAS.cKa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Kim
      (Kim et al., 1996)
      Saccharomyces cerevisiae UAS construct a of MacKay
      (MacKay et al., 2003)
      Secondary FlyBase IDs
      • FBal0050938
      • FBal0146704
      References (43)