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General Information
Symbol
Dmel\hebetetO.cLa
Species
D. melanogaster
Name
Tn10 tetracycline operator construct a of Li
FlyBase ID
FBal0240541
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

hebe cDNA is cloned downstream from tetO sequences.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Three independent insertions of hebeTn10\tetR exhibit increases in median life span in males ranging from 7 to 26%, while increases in females range from 6 to 23%.

Two P{tetR-hebe} insertions, P{tetR-hebe}DX2 and P{tetR-hebe}AX, yield increases in median life span in females of 22 and 38%, respectively, whle no significant effect is found in males. In a background containing both Tn10\tetRM2.alt.Scer\UAS.T:Hsim\VP16 and Scer\GAL4D42 these insertions still show an increased life span in female flies but not male flies and an increase in median life span in both males and females, ranging from 9 to 37%.

hebeTn10\tetR overexpression mutants (under the control of Scer\GAL4D42 and Tn10\tetRM2.alt.Scer\UAS.T:Hsim\VP16) exhibit increased fecundity in late adult life (days 30-40) and reduced fecundity in earlier adult life (days 10-20) when DOX is added in incremental amounts from hatching.

hebeTn10\tetR overexpression mutants (under the control of Scer\GAL4D42 and Tn10\tetRM2.alt.Scer\UAS.T:Hsim\VP16), where DOX administration is initiated at age 40 days, exhibit increased female fecundity at late ages at one or more DOX concentrations. The late-age administration of drug had no negative effect on female survival.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (4)
Reported As
Symbol Synonym
hebeTn10\tetO.cLa
hebeTn10\tetR
hebetetO.cLa
Name Synonyms
Tn10 tetracycline operator construct a of Li
Secondary FlyBase IDs
    References (2)