Three independent insertions of hebe^Tn10\tetR exhibit increases in median life span in males ranging from 7 to 26%, while increases in females range from 6 to 23%.

Two P{tetR-hebe} insertions, P{tetR-hebe}DX2 and P{tetR-hebe}AX, yield increases in median life span in females of 22 and 38%, respectively, whle no significant effect is found in males. In a background containing both Tn10\tetR^{M2.alt.Scer\UAS.T:Hsim\VP16} and Scer\GAL4^D42 these insertions still show an increased life span in female flies but not male flies and an increase in median life span in both males and females, ranging from 9 to 37%.

hebe^Tn10\tetR overexpression mutants (under the control of Scer\GAL4^D42 and Tn10\tetR^{M2.alt.Scer\UAS.T:Hsim\VP16}) exhibit increased fecundity in late adult life (days 30-40) and reduced fecundity in earlier adult life (days 10-20) when DOX is added in incremental amounts from hatching.

hebe^Tn10\tetR overexpression mutants (under the control of Scer\GAL4^D42 and Tn10\tetR^{M2.alt.Scer\UAS.T:Hsim\VP16}), where DOX administration is initiated at age 40 days, exhibit increased female fecundity at late ages at one or more DOX concentrations. The late-age administration of drug had no negative effect on female survival.