FlyBase Allele Report: Dmel\dlg1[A40.2]

General Information

Symbol

Dmel\dlg1^A40.2

Species

D. melanogaster

Name

FlyBase ID

FBal0240608

Feature type

allele

Associated gene

Dmel\dlg1

Associated Insertion(s)

Carried in Construct

Also Known As

dlg^40.2, dlg^40-2

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Mendoza-Topaz et al., 2008)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

P{EPgy2}dlg1^EY05003

(Mendoza-Topaz et al., 2008)

Cytology

Nature of the lesion

Statement

Reference

Imprecise excision of P{EPgy2}dlg1^EY05003 has deleted from the insertion site 3' into exon 8. The deleted sequence is all specific to isoform A.

(Mendoza-Topaz et al., 2008)

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of cancer

CEA with dlg1²

(Bunker et al., 2015)

CEA

(Parisi et al., 2014)

model of benign neoplasm

CEA

(de Vreede et al., 2018)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of cancer

is ameliorated by Ras85D^V12.UAS

(Parisi et al., 2014)

is exacerbated by egr^KK103432

(Parisi et al., 2014)

is exacerbated by Myd88^VDRC.cUa

(Parisi et al., 2014)

is exacerbated by grim^UAS.cUa

(Parisi et al., 2014)

is ameliorated by egr^UAS.Venus

(Parisi et al., 2014)

is ameliorated by Tl^UASp.Venus

(Parisi et al., 2014)

is exacerbated by Pvr^KK101575

(Parisi et al., 2014)

is exacerbated by spz^KK112908

(Parisi et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

embryonic/larval brain

(Mendoza-Topaz et al., 2008)

embryonic/larval hemocyte | larval stage

(Parisi et al., 2014)

imaginal disc | larval stage

(Mendoza-Topaz et al., 2008)

presynaptic membrane & neuromuscular junction | larval stage

(Mendoza-Topaz et al., 2008)

wing disc

(Parvy et al., 2019, de Vreede et al., 2018, Parisi et al., 2014)

wing disc | third instar larval stage

(Harris et al., 2016)

Detailed Description

Statement

Reference

dlg1^A40.2 larval wing discs exhibit tumors, as well as evident apoptosis (Dcp1 staining).

(Parvy et al., 2019)

dlg1^A40.2 hemizygotes show wing disc overgrowth, associated with a significant increase in cell number, as compared to controls.

(de Vreede et al., 2018)

The wing discs of dlg1^A40.2 hemizygous third instar larvae show epithelial cell polarity defects and hyperplasia, as compared to controls.

(Harris et al., 2016)

dlg1²/dlg1^A40.2 transheterozygosity leads to the formation of large tumors in the third instar larval wing disc.

(Bunker et al., 2015)

dlg1^A40.2 mutant larvae display wing disc tumors and a severe increase in the density of circulating hemocytes, as compared to controls.

(Parisi et al., 2014)

dlg1^A40.2 homozygous larvae have an enlarged brain, and tumorous imaginal discs.

There is a significant increase in the length of each pre-synaptic density at larval neuromuscular junctions in dlg1^A40.2 homozygotes compared to wild-type.

Electrophysiological readings from the neuromuscular junctions of dlg1^A40.2 homozygotes show significantly decreased evoked excitatory junction potential amplitude compared to controls.

(Mendoza-Topaz et al., 2008)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Def^SK4

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^αTub84B.PL/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^btl.PS/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^apolpp.PB/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^apolpp.PB/Def^UAS.cTa/Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by imd¹

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Rel^E20

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by imd^KK109863/Scer\GAL4^btl.PS

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^apolpp.PB/imd^KK109863

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^apolpp.PB/Myd88^GD9716

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^apolpp.PB/imd^KK109863/Def^UAS.cTa

(Parvy et al., 2019)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^Hml.Δ/grim^UAS.cUa

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by spz^KK112908/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by spz^KK112908/Scer\GAL4^He.PZ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Myd88^VDRC.cUa/Scer\GAL4^ppl.PP

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Myd88^VDRC.cUa/Scer\GAL4^Cg.PA

(Parisi et al., 2014)

dlg1^A40.2 has increased cell number | larval stage phenotype, enhanceable by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Myd88^VDRC.cUa/Scer\GAL4^Lsp2.PH

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Tl^UASp.Venus/Scer\GAL4^Cg.PA/egr^KK103432

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^Hml.Δ/egr^KK103432

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, enhanceable by Scer\GAL4^Hml.Δ/Pvr^KK101575

(Parisi et al., 2014)

NOT Enhanced by

Statement

Reference

dlg1^A40.2 has tumorigenic | larval stage phenotype, non-enhanceable by Myd88^VDRC.cUa/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, non-enhanceable by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ/egr^KK103432

(Parisi et al., 2014)

Suppressed by

Statement

Reference

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Def^SK4

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Scer\GAL4^αTub84B.PL/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Scer\GAL4^btl.PS/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Scer\GAL4^apolpp.PB/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Scer\GAL4^apolpp.PB/Def^UAS.cTa/Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by imd¹

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Rel^E20

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by imd^KK109863/Scer\GAL4^btl.PS

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Scer\GAL4^apolpp.PB/imd^KK109863

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible by Scer\GAL4^apolpp.PB/Myd88^GD9716

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^apolpp.PB/imd^KK109863/Def^UAS.cTa

(Parvy et al., 2019)

dlg1^A40.2 has increased cell death | larval stage phenotype, suppressible | partially by Scer\GAL4^apolpp.PB/Def^UAS.cTa/Myd88^GD9716

(Parvy et al., 2019)

dlg1^A40.2 has increased cell number | larval stage phenotype, suppressible | partially by Scer\GAL4^Hml.Δ/grim^UAS.cUa

(Parisi et al., 2014)

dlg1^A40.2 has increased cell number | larval stage phenotype, suppressible by Pvr^KK101575/Scer\GAL4^He.PZ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, suppressible | partially by Tl^UASp.Venus/Scer\GAL4^ppl.PP

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, suppressible | partially by Tl^UASp.Venus/Scer\GAL4^Cg.PA

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, suppressible | partially by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, suppressible | partially by Scer\GAL4^Hml.Δ/egr^UAS.Venus

(Parisi et al., 2014)

dlg1^A40.2 has increased cell number | larval stage phenotype, suppressible by Scer\GAL4^Hml.Δ/Pvr^KK101575

(Parisi et al., 2014)

NOT suppressed by

Statement

Reference

dlg1^A40.2 has tumorigenic | larval stage phenotype, non-suppressible by Tl^UASp.Venus/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, non-suppressible by Tl^UASp.Venus/Scer\GAL4^Cg.PA/egr^KK103432

(Parisi et al., 2014)

dlg1^A40.2 has tumorigenic | larval stage phenotype, non-suppressible by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ/egr^KK103432

(Parisi et al., 2014)

Other

Statement

Reference

Scer\GAL4^Hml.Δ, dlg1^A40.2, grim^UAS.cUa has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Hml.Δ, dlg1^A40.2, spz^KK112908 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^He.PZ, dlg1^A40.2, spz^KK112908 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^ppl.PP, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^ppl.PP, Tl^UASp.Venus, dlg1^A40.2 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Cg.PA, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Lsp2.PH, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2, egr^KK103432 has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^UAS.Venus has increased cell death | larval stage phenotype

(Parisi et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Pvr^KK101575, Scer\GAL4^Hml.Δ, dlg1^A40.2 has decreased cell death | larval stage phenotype

(Parisi et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

dlg1^A40.2 has wing disc phenotype, enhanceable by Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Def^SK4

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^αTub84B.PL/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^btl.PS/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^apolpp.PB/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^apolpp.PB/Def^UAS.cTa/Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by imd¹

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Rel^E20

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by imd^KK109863/Scer\GAL4^btl.PS

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^apolpp.PB/imd^KK109863

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^apolpp.PB/Myd88^GD9716

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^apolpp.PB/imd^KK109863/Def^UAS.cTa

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^Hml.Δ/grim^UAS.cUa

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by spz^KK112908/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by spz^KK112908/Scer\GAL4^He.PZ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by Myd88^VDRC.cUa/Scer\GAL4^ppl.PP

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by Myd88^VDRC.cUa/Scer\GAL4^Cg.PA

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by Myd88^VDRC.cUa/Scer\GAL4^Lsp2.PH

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by Tl^UASp.Venus/Scer\GAL4^Cg.PA/egr^KK103432

(Parisi et al., 2014)

dlg1^A40.2 has embryonic/larval hemocyte | larval stage phenotype, enhanceable by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^Hml.Δ/egr^KK103432

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, enhanceable by Scer\GAL4^Hml.Δ/Pvr^KK101575

(Parisi et al., 2014)

NOT Enhanced by

Statement

Reference

dlg1^A40.2 has wing disc phenotype, non-enhanceable by Myd88^VDRC.cUa/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, non-enhanceable by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ/egr^KK103432

(Parisi et al., 2014)

Suppressed by

Statement

Reference

dlg1^A40.2 has wing disc phenotype, suppressible by Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Def^SK4

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^αTub84B.PL/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^btl.PS/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^apolpp.PB/Def^KK111656

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^apolpp.PB/Def^UAS.cTa/Def^SK3

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by imd¹

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Rel^E20

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by imd^KK109863/Scer\GAL4^btl.PS

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^apolpp.PB/imd^KK109863

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^apolpp.PB/Myd88^GD9716

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible | partially by Scer\GAL4^apolpp.PB/imd^KK109863/Def^UAS.cTa

(Parvy et al., 2019)

dlg1^A40.2 has wing disc phenotype, suppressible by Scer\GAL4^apolpp.PB/Def^UAS.cTa/Myd88^GD9716

(Parvy et al., 2019)

dlg1^A40.2 has embryonic/larval hemocyte | larval stage phenotype, suppressible | partially by Scer\GAL4^Hml.Δ/grim^UAS.cUa

(Parisi et al., 2014)

dlg1^A40.2 has embryonic/larval hemocyte | larval stage phenotype, suppressible by Pvr^KK101575/Scer\GAL4^He.PZ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, suppressible | partially by Tl^UASp.Venus/Scer\GAL4^ppl.PP

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, suppressible | partially by Tl^UASp.Venus/Scer\GAL4^Cg.PA

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, suppressible | partially by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, suppressible | partially by Scer\GAL4^Hml.Δ/egr^UAS.Venus

(Parisi et al., 2014)

dlg1^A40.2 has embryonic/larval hemocyte | larval stage phenotype, suppressible by Scer\GAL4^Hml.Δ/Pvr^KK101575

(Parisi et al., 2014)

NOT suppressed by

Statement

Reference

dlg1^A40.2 has wing disc phenotype, non-suppressible by Tl^UASp.Venus/Scer\GAL4^Hml.Δ

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, non-suppressible by Tl^UASp.Venus/Scer\GAL4^Cg.PA/egr^KK103432

(Parisi et al., 2014)

dlg1^A40.2 has wing disc phenotype, non-suppressible by Ras85D^V12.UAS/Scer\GAL4^Hml.Δ/egr^KK103432

(Parisi et al., 2014)

Other

Statement

Reference

Scer\GAL4^Hml.Δ, dlg1^A40.2, grim^UAS.cUa has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Hml.Δ, dlg1^A40.2, spz^KK112908 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^He.PZ, dlg1^A40.2, spz^KK112908 has wing disc phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^ppl.PP, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^ppl.PP, Tl^UASp.Venus, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Cg.PA, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Myd88^VDRC.cUa, Scer\GAL4^Lsp2.PH, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Cg.PA, Tl^UASp.Venus, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^UAS.Venus has wing disc phenotype

(Parisi et al., 2014)

Ras85D^V12.UAS, Scer\GAL4^Hml.Δ, dlg1^A40.2, egr^KK103432 has wing disc phenotype

(Parisi et al., 2014)

Pvr^KK101575, Scer\GAL4^Hml.Δ, dlg1^A40.2 has wing disc phenotype

(Parisi et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

imd¹, Rel^E20, Def^SK3 or Def^SK4 enhance the tumor phenotype and suppress the associated apoptosis (Dcp1 staining) observed in dlg1^A40.2 wing discs; the same happens upon the expression of Def^KK111656 under the control of either Scer\GAL4^αTub84B.PL, Scer\GAL4^apolpp.PB or Scer\GAL4^btl.PS, upon the expression of imd^KK109863 under the control of Scer\GAL4^btl.PS or Scer\GAL4^apolpp.PB, or upon the expression of Myd88^GD9716 under the control of Scer\GAL4^apolpp.PB. Def^SK3 and Def^SK4 do not affect the cell division rate in dlg1^A40.2 wing discs.

Scer\GAL4^apolpp.PB-driven expression of Def^UAS.cTa in Def^SK3, dlg1^A40.2 double mutants, imd^KK109863, dlg1^A40.2 double mutants, or Myd88^GD9716, dlg1^A40.2 double mutants partially re-establishes the original dlg1^A40.2 phenotypes.

Injecting synthetic Defensin protein into dlg1^A40.2 larvae enhances the apoptosis observed in their wing discs. Injecting synthetic Defensin protein into Def^SK3, dlg1^A40.2 and egr³, dlg1^A40.2 larvae re-establishes the increased apoptosis observed in dlg1^A40.2 larvae.

(Parvy et al., 2019)

The tumor phenotype of dlg1^A40.2/dlg1² transheterozygous third instar larval wing discs is partially suppressed by the expression of Socs36E^{Scer\UAS.P\T.cCa} under the control of Scer\GAL4^en-e16E, as it leads to a significantly decreased cell number in the discs' posterior compartment, and is enhanced by the expression of either ph-p^GD4480 or Su(z)2^KK103634 under the control of Scer\GAL4^en-e16E, as they lead to a significantly increased cell number in the discs' posterior compartment.

(Bunker et al., 2015)

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is virtually abrogated by the expression of egr^KK103432, alone or in combination with Ras85D^V12.UAS, by the expression of Pvr^KK101575 alone or by the expression of spz^KK112908 alone, is significantly decreased by the expression of grim^UAS.cUa, is significantly increased by the expression of egr^UAS.Venus, but does not seem to be affected by the expression of Ras85D^V12.UAS alone (all expression conditions are under the control of the Scer\GAL4^Hml.Δ driver).

The apoptosis observed in dlg1^A40.2 mutant wing disc tumors is also virtually abrogated by the expression of spz^KK112908 under the control of Scer\GAL4^He.PZ, by the expression of Myd88^VDRC.cUa under the control of either Scer\GAL4^ppl.PP, Scer\GAL4^Cg.PA or Scer\GAL4^Lsp2.PH, or by the co-expression of Tl^UASp.Venus and egr^KK103432 under the control of Scer\GAL4^Cg.PA, while being significantly increased by the expression of Tl^UASp.Venus under the control of either Scer\GAL4^ppl.PP or Scer\GAL4^Cg.PA.

(Parisi et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

dlg1^A40.2

(Harris et al., 2016)

dlg^40-2

(de Vreede et al., 2018, Donohoe et al., 2018, Bunker et al., 2015)

dlg^40.2

(Khoury and Bilder, 2020, Parvy et al., 2019, Parisi et al., 2014)

dlgA^40.2

(Mendoza-Topaz et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

Open Close