Allele Dmel\dlg1^S97-5

General Information
Symbol	Dmel\dlg1^S97-5	Species	D. melanogaster
Name		FlyBase ID	FBal0240610
Feature type	allele	Associated gene	Dmel\dlg1

Allele class
Mutagen	Delta2-3
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	Delta2-3 (Mendoza-Topaz et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{GawB}dlg1^NP7225 (Mendoza-Topaz et al., 2008)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion has resulted in an 8kb deletion that removes exons 1-3 and a portion of exon 4. The deleted sequence is all specific to isoform S97. (Mendoza-Topaz et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	courtship behavior defective \| recessive (Mendoza-Topaz et al., 2008) locomotor rhythm defective \| adult stage \| recessive (Mendoza-Topaz et al., 2008) mating defective \| recessive (Mendoza-Topaz et al., 2008) phototaxis defective \| adult stage \| recessive (Mendoza-Topaz et al., 2008)
Phenotype Manifest In

Detailed Description
	Statement Reference dlg1[S97-5] flies have normal climbing ability and show a normal response in an olfactory avoidance assay (tested with benzaldehyde). Adult dlg1[S97-5] homozygous flies have severe defects in phototaxis: scores in phototaxis assays are similar to those seen in flies lacking normal phototransduction. dlg1[S97-5] homozygous males when placed with a single virgin female, spend 40% less time courting than wild-type controls, and only 20% mate within 10 minutes compared to 80% of controls. Under alternating light/dark (12 hours) conditions, circadian patterns of locomotor activity in dlg1[S97-5] homozygous adults are only slightly abnormal. However, when flies are moved to permanent dark conditions circadian patterns of locomotor activity are gradually lost. Electrophysiological readings from the neuromuscular junctions of dlg1[S97-5] homozygotes show significantly increased mini excitatory junction potential amplitude and normal evoked excitatory junction potential amplitude. Together these indicate decreased quantal content. (Mendoza-Topaz et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	dlg1^S97-5 is rescued by Scer\GAL4^elav-C155/dlg1^{S97N.Scer\UAS.T:Avic\GFP-EGFP} (Mendoza-Topaz et al., 2008, Mendoza-Topaz et al., 2008)
Not rescued by	dlg1^S97-5 is not rescued by Scer\GAL4^elav-C155/dlg1^{Scer\UAS.T:Avic\GFP} (Mendoza-Topaz et al., 2008, Mendoza-Topaz et al., 2008)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	dlg1^S97-5 dlgS97⁵ (Mendoza-Topaz et al., 2008)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Mendoza-Topaz et al., 2008, J. Neurosci. 28(1): 304--314 DLGS97/SAP97 is developmentally upregulated and is required for complex adult behaviors and synapse morphology and function. [FBrf0202247]

Allele Dmel\dlg1S97-5

Allele Dmel\dlg1^S97-5