Allele Dmel\NT1^{dsRNA.pro.Scer\UAS}

General Information
Symbol	Dmel\NT1^{dsRNA.pro.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0240745
Feature type	allele	Associated gene	Dmel\NT1

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - RNAi
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Zhu et al., 2008) in vitro construct - RNAi (Zhu et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of inverted repeat sequences corresponding to the pro-domain region of NT1. (Zhu et al., 2008)
Carried in construct	P{UAS-proNT1.RNAi} (Zhu et al., 2008)
Cytology
Phenotypic Data
Phenotypic Class
	increased cell death \| embryonic stage 17, with NT1⁴¹, Scer\GAL4^sim.PS (Zhu et al., 2008) increased cell death \| embryonic stage 17 (with NT1⁴¹), with Scer\GAL4^sim.PS (Zhu et al., 2008) neuroanatomy defective, with Scer\GAL4^how-24B (Zhu et al., 2008)
Phenotype Manifest In

Detailed Description
	Statement Reference Targeted expression of NT1[IR.pro.Scer\UAS] in the CNS midline (under the control of Scer\GAL4[sim.PS]) in a NT1[41.Δ.w] heterozygous background results in a significant increase in apoptosis throughout the CNS cortex compared to controls at embryonic stage 17. Targeted expression of NT1[IR.pro.Scer\UAS] in all the neurons (under the control of Scer\GAL4[elav-C155]) does not significantly affect axon guidance, whereas expression in the muscle (under the control of Scer\GAL4[how-24B]) significantly alters axon guidance and routing. (Zhu et al., 2008) Targeted expression of NT1[dsRNA.pro.Scer\UAS] in the CNS midline (under the control of Scer\GAL4[sim.PS]) in a NT1[41] heterozygous background results in a significant increase in apoptosis throughout the CNS cortex compared to controls at embryonic stage 17. Targeted expression of NT1[dsRNA.pro.Scer\UAS] in all the neurons (under the control of Scer\GAL4[elav-C155]) does not significantly affect axon guidance, whereas expression in the muscle (under the control of Scer\GAL4[how-24B]) significantly alters axon guidance and routing. (Zhu et al., 2008)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	NT1[IR.pro.Scer\UAS] knocks-down all NT1 transcripts. (Zhu et al., 2008)
External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	NT1^{dsRNA.pro.Scer\UAS} NT1^{IR.pro.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 2 )
Research paper	Zhu et al., 2008, PLoS Biol. 6(11): e284 Drosophila neurotrophins reveal a common mechanism for nervous system formation. [FBrf0206302]
FlyBase analysis	FlyBase, 1992-, FlyBase curation. FlyBase curation. [FBrf0105495]

Allele Dmel\NT1dsRNA.pro.Scer\UAS

Allele Dmel\NT1^{dsRNA.pro.Scer\UAS}