FlyBase Allele Report: Dmel\Cdc42[JF02855]

General Information

Symbol

Dmel\Cdc42^JF02855

Species

D. melanogaster

Name

FlyBase ID

FBal0240825

Feature type

allele

Associated gene

Dmel\Cdc42

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02855}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02855}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02855

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of kidney disease

CEA

(Zhang et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

eye, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

larval pericardial cell, with Scer\GAL4^Ugt36A1.PK

(Zhang et al., 2013)

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in rough and misshapen eye phenotype.

(Pletcher et al., 2019)

Expression of Cdc42^JF02855 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

(Ugrankar et al., 2015)

Scer\GAL4^Dot.PK-mediated expression of Cdc42^JF02855 reduces the normal accumulation of ANF-RFP (expressed via Rnor\ANF^{Mhc.T:Disc\RFP}) in pericardial nephrocytes.

(Zhang et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Cdc42^JF02855, Scer\GAL4^repo.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Cdc42^JF02855, Scer\GAL4^repo.PU is a suppressor of neoplasia | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Cdc42^JF02855, Scer\GAL4^repo.PU is a suppressor of larval brain | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Cdc42^JF02855, Scer\GAL4^repo.PU is a suppressor of larval brain neuropil glial cell | third instar larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo.PU, btl::Egfr^λ.UAS

(Chen et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28021

y¹ v¹; P{TRiP.JF02855}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Cdc42^JF02855

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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