FlyBase Allele Report: Dmel\Appl[JF02878]

General Information

Symbol

Dmel\Appl^JF02878

Species

D. melanogaster

Name

FlyBase ID

FBal0240847

Feature type

allele

Associated gene

Dmel\Appl

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02878}

Also Known As

UAS-Appl^RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02878}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02878

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of Alzheimer's disease

CEA

(Singh et al., 2017)

model of Alzheimer's disease 1

CEA

(Panchal and Tiwari, 2020)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell adhesion | oogenesis, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

abnormal cell migration | oogenesis, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

abnormal locomotor behavior | adult stage | progressive, with Scer\GAL4^elav-C155

(Singh et al., 2017)

abnormal planar polarity, with Scer\GAL4^hs.2sev

(Singh and Mlodzik, 2012)

short lived, with Scer\GAL4^elav-C155

(Singh et al., 2017)

visible | adult stage, with Scer\GAL4^GMR.PF

(Singh et al., 2017)

Phenotype Manifest In

border follicle cell, with Scer\GAL4^slbo.2.6

(Raza et al., 2019)

eye, with Scer\GAL4^GMR.PF

(Singh et al., 2017)

interommatidial bristle, with Scer\GAL4^GMR.PF

(Singh et al., 2017)

ommatidium, with Scer\GAL4^GMR.PF

(Singh et al., 2017)

photoreceptor cell R3, with Scer\GAL4^hs.2sev

(Singh and Mlodzik, 2012)

photoreceptor neuron, with Scer\GAL4^hs.2sev

(Singh and Mlodzik, 2012)

Detailed Description

Statement

Reference

The expression of Appl^JF02878 under the control of Scer\GAL4^slbo.2.6 leads to some border cell cluster disassociation events, and frequently results in prevalent border cell migration failure or delay.

(Raza et al., 2019)

Adult flies expressing Appl^JF02878 under the control of Scer\GAL4^GMR.PF display eye morphology defects of varying severity (from mild glossy appearance with no size reduction ranging to very small glossy eyes with highly degenerated ommatidia and bristle loss). Expression under the Scer\GAL4^elav-C155 driver leads to age-progressive decrease of locomotor (climbing) ability and shorter lifespan.

(Singh et al., 2017)

Expression of Appl^JF02878 in the eye under the control of Scer\GAL4^hs.2sev results in loss of photoreceptors and planar cell polarity (PCP)-like phenotypes characterised by the presence of R3-R3 symmetrical clusters.

(Singh and Mlodzik, 2012)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Appl^JF02878, Scer\GAL4^hs.2sev has abnormal planar polarity phenotype, enhanceable by hbs^RNAi.UAS.cUa, Scer\GAL4^hs.2sev

(Singh and Mlodzik, 2012)

Phenotype Manifest In

Enhanced by

Statement

Reference

Appl^JF02878, Scer\GAL4^hs.2sev has photoreceptor cell R3 phenotype, enhanceable by hbs^RNAi.UAS.cUa, Scer\GAL4^hs.2sev

(Singh and Mlodzik, 2012)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of hbs^VDRC.cUa with Appl^JF02878 under the control of Scer\GAL4^hs.2sev significantly enhances the hbs^VDRC.cUa-induce planar cell polarity (PCP) phenotype.

(Singh and Mlodzik, 2012)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

28043

y¹ v¹; P{TRiP.JF02878}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Appl^JF02878

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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