FB2025_01 , released February 20, 2025
Allele: Dmel\Atg9JF02891
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General Information
Symbol
Dmel\Atg9JF02891
Species
D. melanogaster
Name
FlyBase ID
FBal0240859
Feature type
allele
Associated gene
Dmel\Atg9
Associated Insertion(s)
Carried in Construct
P{TRiP.JF02891}
Also Known As
UAS-Atg9-RNAi, Atg9 RNAi, UAS-Atg9RNAi
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Perkins et al., 2009)
Mutagen
in vitro construct
(Perkins et al., 2009)
Progenitor genotype
Carried in construct
P{TRiP.JF02891}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
dsRNA-JF02891
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  Parkinson's disease
      CEA
      (Yi et al., 2024)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Atg9JF02891 under the control of Scer\GAL4Myo31DF-NP0001 results in significantly delayed midgut degradation after pupariation, with significantly increased size of the gastric caeca 0 hrs and 4 hrs after puparium formation, persistence of the midgut at 12 h after puparium formation, and significantly decreased autophagy levels 2 hrs after puparium formation, as compared to controls.

      Expression of Atg9JF02891 under the control of Scer\GAL4cg.PU results in a decrease in starvation-induced autophagy in the larval fat body, as compared to controls.

      (Xu et al., 2015)

      Expression of Atg9JF02891 under the control of Scer\GAL4Mef2.PR is able to significantly suppress the formation of autophagosomes in the muscles of chloroquine-treated larvae starved on low-nutrient food for 6 hours.

      (Zirin et al., 2013)

      Expression of Atg9JF02891 using Scer\GAL4Act5C.PP results in basal autophagy defects in larval fat body cell somatic clones.

      (Pircs et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Atg9JF02891, Scer\GAL4bbg-C96 is an enhancer of visible phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Kwon et al., 2013)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Atg9JF02891, Scer\GAL4GMR.long is a non-suppressor of visible | adult stage phenotype of Ire1UAS.Tag:V5, Scer\GAL4GMR.long

      (Yan et al., 2019)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Atg9JF02891, Scer\GAL4bbg-C96 is an enhancer of wing margin phenotype of Scer\GAL4bbg-C96, domRNAi.Sym.UAS

      (Kwon et al., 2013)
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Atg9JF02891, Scer\GAL4GMR.long is a non-suppressor of eye phenotype of Ire1UAS.Tag:V5, Scer\GAL4GMR.long

      (Yan et al., 2019)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The wing nicking phenotype caused by expression of domdsRNA.Sym.Scer\UAS under the control of Scer\GAL4bbg-C96 is enhanced if the flies are also co-expressing Atg9JF02891.

      (Kwon et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Atg9JF02891
      (Billes et al., 2018, Nagy et al., 2014)
      Atg9[i, JF02891]
      (Nagy et al., 2013)
      atg9RNAi
      (Zhao et al., 2023)
      Name Synonyms
      Secondary FlyBase IDs
        References (23)