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General Information
Symbol
Dmel\cdm177
Species
D. melanogaster
Name
FlyBase ID
FBal0240916
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Nature of the Allele
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the progenitor insertion, resulting in a deletion that removes the majority of the cdm coding sequence.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Homozygous clones in the visual system result in defects in electroretinogram recordings; the on and off transients are absent, and the hyperpolarisation curve is dramatically reduced compared to wild type.

cdm177/Df(3R)DG2 animals derived from females containing cdm177 homozygous germline clones show third larval instar lethality.

The number of synaptic boutons per muscle area is normal at the third larval instar cdm177 neuromuscular junction, although there is a small decrease in the total surface area of muscles 6 and 7 compared to controls. The number of active zones and the length of the postsynaptic density are normal. The ratio of subsynaptic reticulum (SSR) per bouton area and the SSR density are reduced compared to controls.

The amplitude and frequency of miniature excitatory junctional potentials at the larval neuromuscular junction is normal in homozygous cdm177 and cdm177/Df(3R)DG2 animals.

At 2mM extracellular Ca[2+], the evoked excitatory junctional potential (EJP) at the larval neuromuscular junction is normal in homozygous cdm177 and cdm177/Df(3R)DG2 animals. At low concentrations (0.35mM and 0.5mM) extracellular Ca[2+], the amplitude of the evoked EJP at the larval neuromuscular junction is significantly increased in homozygous cdm177 and cdm177/Df(3R)DG2 animals compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
cdm177
Name Synonyms
Secondary FlyBase IDs
    References (1)