Allele Dmel\cdm¹⁷⁷

General Information
Symbol	Dmel\cdm¹⁷⁷	Species	D. melanogaster
Name		FlyBase ID	FBal0240916
Feature type	allele	Associated gene	Dmel\cdm

Allele class	amorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	amorphic allele - genetic evidence (Giagtzoglou et al., 2009)
Mutagen	P-element activity (Giagtzoglou et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{RS5}cdm^5-SZ-3929 (Giagtzoglou et al., 2009)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion, resulting in a deletion that removes the majority of the cdm coding sequence. (Giagtzoglou et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive \| third instar larval stage (Giagtzoglou et al., 2009) lethal \| third instar larval stage (with cdm¹⁶⁴) (Giagtzoglou et al., 2009) lethal \| third instar larval stage (with cdm^FY561) (Giagtzoglou et al., 2009) lethal \| third instar larval stage (with cdm^sd4) (Giagtzoglou et al., 2009) lethal \| third instar larval stage (with cdm^sd6) (Giagtzoglou et al., 2009) lethal \| third instar larval stage (with Df(3R)DG2) (Giagtzoglou et al., 2009) lethal \| third instar larval stage (with Df(3R)Exel6178) (Giagtzoglou et al., 2009) neuroanatomy defective \| third instar larval stage (Giagtzoglou et al., 2009) neurophysiology defective \| third instar larval stage (Giagtzoglou et al., 2009) neurophysiology defective \| third instar larval stage (with Df(3R)DG2) (Giagtzoglou et al., 2009)
Phenotype Manifest In
	embryonic/larval neuromuscular junction (Giagtzoglou et al., 2009) embryonic/larval neuromuscular junction (with Df(3R)DG2) (Giagtzoglou et al., 2009) postsynaptic membrane (Giagtzoglou et al., 2009)
Detailed Description
	Statement Reference Homozygous clones in the visual system result in defects in electroretinogram recordings; the on and off transients are absent, and the hyperpolarisation curve is dramatically reduced compared to wild type. cdm[177]/Df(3R)DG2 animals derived from females containing cdm[177] homozygous germline clones show third larval instar lethality. The number of synaptic boutons per muscle area is normal at the third larval instar cdm[177] neuromuscular junction, although there is a small decrease in the total surface area of muscles 6 and 7 compared to controls. The number of active zones and the length of the postsynaptic density are normal. The ratio of subsynaptic reticulum (SSR) per bouton area and the SSR density are reduced compared to controls. The amplitude and frequency of miniature excitatory junctional potentials at the larval neuromuscular junction is normal in homozygous cdm[177] and cdm[177]/Df(3R)DG2 animals. At 2mM extracellular Ca[2+], the evoked excitatory junctional potential (EJP) at the larval neuromuscular junction is normal in homozygous cdm[177] and cdm[177]/Df(3R)DG2 animals. At low concentrations (0.35mM and 0.5mM) extracellular Ca[2+], the amplitude of the evoked EJP at the larval neuromuscular junction is significantly increased in homozygous cdm[177] and cdm[177]/Df(3R)DG2 animals compared to controls. (Giagtzoglou et al., 2009)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	cdm¹⁷⁷/cdm¹⁶⁴ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009) cdm¹⁷⁷ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009, Giagtzoglou et al., 2009) cdm^FY561/cdm¹⁷⁷ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009) cdm^sd4/cdm¹⁷⁷ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009) cdm^sd6/cdm¹⁷⁷ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009) Df(3R)DG2/cdm¹⁷⁷ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009) Df(3R)Exel6178/cdm¹⁷⁷ is rescued by cdm^{T:Ivir\HA1,T:Zzzz\FLAG} (Giagtzoglou et al., 2009)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cdm¹⁷⁷ imp13¹⁷⁷ (Giagtzoglou et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Giagtzoglou et al., 2009, J. Neurosci. 29(17): 5628--5639 Importin 13 regulates neurotransmitter release at the Drosophila neuromuscular junction. [FBrf0207838]

Allele Dmel\cdm177

Allele Dmel\cdm¹⁷⁷