FlyBase Allele Report: Dmel\Arc1[UAS.cMb]

General Information

Symbol

Dmel\Arc1^UAS.cMb

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct b of Mattaliano

FlyBase ID

FBal0240954

Feature type

allele

Associated gene

Dmel\Arc1

Associated Insertion(s)

Carried in Construct

P{UAS-Arc1.WT}

Also Known As

UAS-Arc1

Key Links

Transgenic product class

wild_type

(Mattaliano et al., 2007)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Mattaliano et al., 2007)

Mutagen

in vitro construct

(Mattaliano et al., 2007)

Progenitor genotype

Carried in construct

P{UAS-Arc1.WT}

Cytology

Description

UASt regulatory sequences drive expression of the Arc1 open-reading frame.

(Mattaliano et al., 2007)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Arc1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^Appl.G1a

(Keith et al., 2021)

abnormal developmental rate, with Scer\GAL4^mex1.PU

(Keith et al., 2021)

abnormal locomotor behavior | adult stage, with Scer\GAL4^Toll-6-D42

(Xu et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Arc1^UAS.cMb under the control of Scer\GAL4^elav-C155 present a significant decrease in climbing ability, as compared to controls.

(Xu et al., 2019)

Expression of Arc1^Scer\UAS.cMb under the control of Scer\GAL4^Arc1.PM results in decreased larval floating in a density-based assay for body fat content, but no effect on food consumption or physical activity.

Expression of Arc1^Scer\UAS.cMb under the control of Scer\GAL4^E347 results in no difference in larval floating in a density-based assay for body fat content as compared to controls.

(Mosher et al., 2015)

Presynaptic expression of Arc1^Scer\UAS.cMb (under the control of Scer\GAL4^elav-C155) has no effect on bouton number or morphology compared to controls.

(Mattaliano et al., 2007)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-enhancer of visible | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-enhancer of decreased rate of adult locomotory behavior phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-enhancer of increased cell death | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

NOT Suppressor of

Statement

Reference

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-suppressor of visible | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-suppressor of decreased rate of adult locomotory behavior phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-suppressor of increased cell death | adult stage phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-enhancer of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-enhancer of adult CNS neuron | decreased number phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

NOT Suppressor of

Statement

Reference

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-suppressor of eye phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Arc1^UAS.cMb, Scer\GAL4^elav-C155 is a non-suppressor of adult CNS neuron | decreased number phenotype of Hsap\MAPT^R406W.UAS, Scer\GAL4^elav-C155

(Schulz et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^elav-C155/Arc1^UAS.cMb rescues Arc1^esm18

(Mattaliano et al., 2007)

Partially rescues

Arc1^UAS.cMb/Scer\GAL4^arm.PS partially rescues Arc1^E8

(Keith et al., 2021)

Arc1^UAS.cMb/Scer\GAL4^GMR96A08 partially rescues Arc1^E8

(Keith et al., 2021)

Arc1^UAS.cMb/Scer\GAL4^phtm.PO partially rescues Arc1^E8

(Keith et al., 2021)

Fails to rescue

Scer\GAL4^drm.7.1/Arc1^UAS.cMb fails to rescue Arc1^E8

(Keith et al., 2021)

Arc1^UAS.cMb/Scer\GAL4^r4 fails to rescue Arc1^E8

(Keith et al., 2021)

Arc1^UAS.cMb/Scer\GAL4^C57 fails to rescue Arc1^E8

(Keith et al., 2021)

Arc1^UAS.cMb/Scer\GAL4^Appl.G1a fails to rescue Arc1^E8

(Keith et al., 2021)

Scer\GAL4^mex1.PU/Arc1^UAS.cMb fails to rescue Arc1^E8

(Keith et al., 2021)

Arc1^UAS.cMb/Scer\GAL4^Akh.PL fails to rescue Arc1^esm18

(Mattaliano et al., 2007)

Arc1^UAS.cMb/Scer\GAL4^386Y fails to rescue Arc1^esm18

(Mattaliano et al., 2007)

Scer\GAL4^c316/Arc1^UAS.cMb fails to rescue Arc1^esm18

(Mattaliano et al., 2007)

Comments

Expression of Arc1^Scer\UAS.cMb under the control of Scer\GAL4^Akh.PL, Scer\GAL4^386Y (in many peptidergic neurons) or Scer\GAL4^c316 does not suppress the resistance phenotype of Arc1^esm18 mutant flies.

Pan-neural expression of two copies of the Arc1^Scer\UAS.cMb transgene (under the control of Scer\GAL4^elav-C155) suppress the resistance phenotype found in Arc1^esm18 mutants more effectively than one copy.

(Mattaliano et al., 2007)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

37532

w^*; P{UAS-Arc1.WT}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Arc1^Scer\UAS.cMb

Arc1^UAS.cMb

Name Synonyms

Saccharomyces cerevisiae UAS construct b of Mattaliano

Secondary FlyBase IDs

References (7)

Report Sections

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