Allele Dmel\Flo-2^Scer\UAS.cHa

General Information
Symbol	Dmel\Flo-2^Scer\UAS.cHa	Species	D. melanogaster
Name		FlyBase ID	FBal0240975
Feature type	allele	Associated gene	Dmel\Flo-2

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Hoehne et al., 2005)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of Flo-2 coding sequences corresponding to the clone LD02581. (Hoehne et al., 2005)
Carried in construct	P{UAS-Flo-2.H} (Hoehne et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	eye, with Scer\GAL4^MZ1369 (Hoehne et al., 2005) macrochaeta, with Scer\GAL4^MZ1369 (Hoehne et al., 2005) ocellus, with Scer\GAL4^MZ1369 (Hoehne et al., 2005) wing, with Scer\GAL4^MZ1369 (Hoehne et al., 2005)
Detailed Description
	Statement Reference Overexpression of Flo-2[Scer\UAS.cHa] under the control of Scer\GAL4[MZ1369] results in compound phenotypic defects including abnormal eyes, ocelli, bristles and wings. (Hoehne et al., 2005)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhanced by
Statement Reference Flo-2^Scer\UAS.cHa, Scer\GAL4^MZ1369 has eye phenotype, enhanceable by Flo-1^Scer\UAS.cHa, Scer\GAL4^MZ1369 (Hoehne et al., 2005) Flo-2^Scer\UAS.cHa, Scer\GAL4^MZ1369 has macrochaeta phenotype, enhanceable by Flo-1^Scer\UAS.cHa, Scer\GAL4^MZ1369 (Hoehne et al., 2005) Flo-2^Scer\UAS.cHa, Scer\GAL4^MZ1369 has ocellus phenotype, enhanceable by Flo-1^Scer\UAS.cHa, Scer\GAL4^MZ1369 (Hoehne et al., 2005) Flo-2^Scer\UAS.cHa, Scer\GAL4^MZ1369 has wing phenotype, enhanceable by Flo-1^Scer\UAS.cHa, Scer\GAL4^MZ1369 (Hoehne et al., 2005)
Additional Comments
Genetic Interactions
Statement Reference Overexpression of Flo-2[Scer\UAS.cHa] and Flo[Scer\UAS.cHa] under the control of Scer\GAL4[MZ1369] results in compound phenotypic defects including abnormal eyes, ocelli, bristles and wings. Wings exhibit a highly variable but severe mutant phenotype, including blisteriing and melanotic cells. Mutant eye discs display a variable number of cone cells andprimary pigment cells per ommatidium, errors in number and positioning of the bristle complexes and mild cell sorting defects. The type of defects caused by Scer\GAL4[MZ1369]-driven misexpression of Flo-2[Scer\UAS.cHa] alone or in tandem with Flo[Scer\UAS.cHa] are largely indistinguishable, although flies overexpressing both proteins display a tendency towards more pronounced defects. (Hoehne et al., 2005)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Flo-2^Scer\UAS.cHa
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Hoehne et al., 2005, Mol. Cell. Neurosci. 30(3): 326--338 Loss- and gain-of-function analysis of the lipid raft proteins Reggie/Flotillin in Drosophila: they are posttranslationally regulated, and misexpression interferes with wing and eye development. [FBrf0191209]

Allele Dmel\Flo-2Scer\UAS.cHa

Allele Dmel\Flo-2^Scer\UAS.cHa