Allele Dmel\kek5^Δ1

General Information
Symbol	Dmel\kek5^Δ1	Species	D. melanogaster
Name		FlyBase ID	FBal0241006
Feature type	allele	Associated gene	Dmel\kek5

Map ( GBrowse )
Allele class	hypomorphic allele - genetic evidence
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	hypomorphic allele - genetic evidence (Evans et al., 2009)
Mutagen	P-element activity (Evans et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References deletion X:19,246,836..19,247,674 comment=An 840 base deletion extending from 426 bases upstream to 58 bases downstream of exon 1 of kek5 as defined by GB:AY195738. (Evans et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{GT1}kek5^BG02535 (Evans et al., 2009)
Nature of the lesion	Statement Reference An 840 bp deletion beginning 426 bp upstream and ending 58 bp downstream of exon 1 of kek5 resulting from the imprecise excision of P{GT1}kek5[BG02535]. (Evans et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	fertile (Evans et al., 2009) short lived \| recessive (Evans et al., 2009) visible (with Df(1)Exel7468) (Evans et al., 2009) visible (with Df(1)JA27) (Evans et al., 2009) visible (with kek5^fe148) (Evans et al., 2009) visible \| recessive (Evans et al., 2009)
Phenotype Manifest In
	crossvein (Evans et al., 2009) crossvein (with Df(1)Exel7468) (Evans et al., 2009) crossvein (with Df(1)JA27) (Evans et al., 2009) crossvein (with kek5^fe148) (Evans et al., 2009) wing blade (Evans et al., 2009) wing blade (with Df(1)Exel7468) (Evans et al., 2009) wing blade (with Df(1)JA27) (Evans et al., 2009)
Detailed Description
	Statement Reference Homozygous kek5[Δ1] mutants produce fertile adults. However, the mutant imagos exhibit decreased viability. kek5[Δ1] and kek5[fe148]/kek5[Δ1] mutant wings exhibit defects in crossvein patterning with a penetrance of about 25-30%. The frequency of crossvein defects is enhanced by hemizygosity over Df(1)Exel7468 or Df(1)JA27. kek5[Δ1] mutant wing defects include truncated or missing posterior crossvein, twigging or forking of the crossvein, ectopic posterior crossvein material, meandering posterior crossvein and ectopic crossveins around the anterior crossvein. The anterior crossvein is rarely deleted or truncated in kek5[Δ1] mutants; more often partial or full-length ectopic crossveins appear adjacent to the anterior crossvein. kek5[Δ1] mutant wings display blisters at low frequency (less than 5%) when homo- or hemizygous, or when either placed over deficiencies for the region Df(1)Exel7468 or Df(1)JA27. (Evans et al., 2009)
External Data
Linkouts
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	kek5^Δ1 (Evans et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Evans et al., 2009, Dev. Biol. 326(1): 36--46 Kekkon5 is an extracellular regulator of BMP signaling. [FBrf0207272]

Allele Dmel\kek5Δ1

Allele Dmel\kek5^Δ1