FB2025_01 , released February 20, 2025
Allele: Dmel\wupA23437
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General Information
Symbol
Dmel\wupA23437
Species
D. melanogaster
Name
FlyBase ID
FBal0241061
Feature type
allele
Associated gene
Dmel\wupA
Associated Insertion(s)
Carried in Construct
Also Known As
Df(1)23437
Key Links
Allele class

loss of function allele

Mutagen
    Nature of the Allele
    Allele class

    loss of function allele

    (Sahota et al., 2009)
    Mutagen
    Progenitor genotype
    Cytology
    Description

    wupA23437 carries a 2 Kb deletion within the promoter region of wupA.

    (Sahota et al., 2009)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        wupA23437 homozygous somatic clones in wandering third instar larval wing discs exhibit a significant and progressive decrease in relative clonal area, which is smaller at 72h than at 48h after clonal induction, as compared to control clones.

        (Casas-Tintó et al., 2016)

        Homozygous wupA23437 mutants show nuclear defects including clumped nuclei in the syncitial embryo.

        wupA23437 mutant embryos fail to cellularize in certain areas, including the characteristic absence of pole cells at the posterior end of the embryo. Milder defects of wupA23437 mutants includes abnormal spindle orientation in about 22% of cases, while 28% show disrupted nuclei and fragmented chromosomes. Mitotic activity is variable across each wupA23437 mutant embryo.

        The number of wupA23437 mutant clones is reduced to 10% of controls in germline mosaics.

        (Sahota et al., 2009)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (6)
        Reported As
        Symbol Synonym
        23437
        (Sahota et al., 2009)
        Df(1) TnI23437
        (Casas-Tintó et al., 2016)
        Df(1)23437
        (Casas-Tintó and Ferrús, 2021, Sahota et al., 2009)
        TnI23437
        (Casas-Tintó et al., 2016)
        l(1)23437RL
        (Casas-Tintó and Ferrús, 2021)
        wupA23437
        Name Synonyms
        Secondary FlyBase IDs
          References (3)