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General Information
Symbol
Dmel\rlGD4697
Species
D. melanogaster
Name
FlyBase ID
FBal0241100
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a rl RNAi construct.

Allele components
Product class / Tool use(s)
Encoded product / tool
Associated Sequence Features
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of rlGD4697 in the posterior wing compartment, under the control of Scer\GAL4en-e16E, generates a wing vein differentiation phenotype.

Depending on the insertion line used, expression under the control of Scer\GAL4Mef2.PR can result in viable flies or late pupal lethality.

Expression of rlGD4697 under the control of Scer\GAL4repo results in lack of glial differentiation in the eye disc, but only mildly affects glial division or migration.

Expression under the control of Scer\GAL4pnr-MD237 results in bristle morphology defects on the notum in 10-20% or 40-50% of the Scer\GAL4pnr-MD237 expression domain, depending on the insertion line used.

Expression under the control of Scer\GAL4pnr-MD237 results in the absence of 20-30% or 90-100% of the Scer\GAL4pnr-MD237-expressing area of the notum, depending on the insertion line used.

Scer\GAL4phm.PO-driven overexpression of rlGD4697 delays pupariation by 6.1 days. The developmental delay, as well as the size increase caused by Scer\GAL4phm.PO-driven overexpression of Ras85DGD12553 is negated by 20-hydroxyecdysone feeding

External Data
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Phenotype Manifest In
Enhanced by
NOT Enhanced by
Statement
Reference
NOT suppressed by
Statement
Reference
Suppressor of
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of rlGD4697 reduces hemocyte proliferation induced by expression of Ras85DV12.Scer\UAS via Scer\GAL4Hml.PG.

Knockdown of rl in a stepdsRNA.Scer\UAS background, through expression of rlGD4697 in the posterior wing compartment (both transgenes under the control of Scer\GAL4en-e16E) generates a more severe rl phenotype than in a wild-type background. The lateral vein L4 is entirely lost, both cross veins are not differentiated and the distal end of the lateral vein L5 is missing.

Expression of stepScer\UAS.FL has no effect on the wing vein defects caused by expression of rlGD4697 in the posterior compartment of the wing, under the control of Scer\GAL4en-e16E.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 1 )
Crossreferences
Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
rlGD4697
Name Synonyms
Secondary FlyBase IDs
    References (10)