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General Information
Symbol
Dmel\Nf-YC40
Species
D. melanogaster
Name
FlyBase ID
FBal0241105
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A6819866T

Amino acid change:

K235term | Nf-YC-PA

Reported amino acid change:

K235term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: K235term.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

axon & photoreceptor cell R7

axon & photoreceptor cell R7 | somatic clone

axon & photoreceptor cell R8

Detailed Description
Statement
Reference

63.7 +/- 8.3% of Nf-YC40 photoreceptor cell R7 neurons mistarget to the M3 layer in the brain (this is the layer in which wild-type R8 cell axons terminate) in animals containing large mutant clones in the eye.

Mutant photoreceptor R8 and R1-R6 neurons target correctly to the M3 layer and the lamina respectively in eyes containing large patches of homozygous tissue.

Homozygous pharate adults have a disorganised array of R7 and R8 photoreceptor axons in the medulla and defects in the rotation of the lamina with respect to the medulla. Mutant ommatidia contain R7 rhabdomeres, as in wild type.

Approximately 75% of mutant photoreceptor R7 axons terminate in the M3 layer of the medulla (this is the layer in which wild-type R8 cell axons terminate) in animals containing large mutant clones in the eye.

Mosaic flies in which a fraction of R7 neurons are mutant show mistargeting to the M3 layer of the medulla in approximately 17% of the mutant neurons.

The targeting of mutant R7 neurons to the temporary R7 layer in the medulla at 30% after puparium formation (APF) is normal, but extension to the final target layer at 70% APF is often disrupted, with many R7 neurons terminating in the M3 layer.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement
Reference

Nf-YC40 has axon & photoreceptor cell R7 | somatic clone phenotype, suppressible | somatic clone by sensE1

NOT suppressed by
Statement
Reference

Nf-YC40 has axon & photoreceptor cell R7 | somatic clone phenotype, non-suppressible | somatic clone by capsC18fs

Enhancer of
Statement
Reference

Nf-YC40 is an enhancer | somatic clone of axon & photoreceptor cell R7 | somatic clone phenotype of pros17.17

Additional Comments
Genetic Interactions
Statement
Reference

The mis-targeting of Nf-YC40 R7 neurons to the M3 layer of the medulla is completely suppressed by sensE1.

The mis-targeting of Nf-YC40 R7 neurons to the M3 layer of the medulla is not suppressed by capsC18fs.

The frequency of mistargeting to the M3 layer by pros17.17 R7 neurons is markedly increased by Nf-YC40.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Nf-YC40
Name Synonyms
Secondary FlyBase IDs
    References (2)