Allele Dmel\Nhe2¹

General Information
Symbol	Dmel\Nhe2¹	Species	D. melanogaster
Name		FlyBase ID	FBal0241142
Feature type	allele	Associated gene	Dmel\Nhe2

Allele class
Mutagen	P-element activity
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	P-element activity (Simons et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EPgy2}Nhe2^EY11323 (Simons et al., 2009)
Nature of the lesion	Statement Reference Imprecise excision of the progenitor insertion, resulting in a 6.1kb deletion. (Simons et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class
	cell lethal \| recessive \| somatic clone (Simons et al., 2009) lethal \| larval stage \| recessive (Simons et al., 2009) planar polarity defective, with Nhe2^{dsRNA.Scer\UAS.WIZ}, Scer\GAL4^hs.2sev (Simons et al., 2009) planar polarity defective (with Nhe2^{dsRNA.Scer\UAS.WIZ}), with Scer\GAL4^hs.2sev (Simons et al., 2009)
Phenotype Manifest In
	embryonic/larval digestive system (Simons et al., 2009) embryonic/larval fat body (Simons et al., 2009) eye, with Nhe2^{dsRNA.Scer\UAS.WIZ}, Scer\GAL4^hs.2sev (Simons et al., 2009) eye (with Nhe2^{dsRNA.Scer\UAS.WIZ}), with Scer\GAL4^hs.2sev (Simons et al., 2009) ommatidium, with Nhe2^{dsRNA.Scer\UAS.WIZ}, Scer\GAL4^hs.2sev (Simons et al., 2009) ommatidium (with Nhe2^{dsRNA.Scer\UAS.WIZ}), with Scer\GAL4^hs.2sev (Simons et al., 2009)
Detailed Description
	Statement Reference Homozygotes die during early larval stages with defects in gut morphology and function and fat body development. Homozygous clones can not be recovered in adult or larval tissue. Expression of Nhe2[dsRNA.Scer\UAS.WIZ] under the control of Scer\GAL4[hs.2sev] in a Nhe2[1]/+ background results in planar cell polarity defects in the eye, as well as general defects in eye morphology and structure. (Simons et al., 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement Reference Nhe2^{dsRNA.Scer\UAS.WIZ}, Nhe2[+], Nhe2¹, Scer\GAL4^hs.2sev is a suppressor \| partially of planar polarity defective phenotype of Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa (Simons et al., 2009)
Phenotype Manifest In
Suppressor of
Statement Reference Nhe2^{dsRNA.Scer\UAS.WIZ}, Nhe2[+], Nhe2¹, Scer\GAL4^hs.2sev is a suppressor \| partially of eye phenotype of Scer\GAL4^hs.2sev, fz^Scer\UAS.cAa (Simons et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference The planar cell polarity defects in the eye that are caused by expression of fz[Scer\UAS.cAa] under the control of Scer\GAL4[hs.2sev] are partially suppressed if the flies also simultaneously co-express Nhe2[dsRNA.Scer\UAS.WIZ] and carry Nhe2[1]/+. (Simons et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Nhe2¹ is rescued by Nhe2^{long.Scer\UAS}/Scer\GAL4^tub.PU (Simons et al., 2009)
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Nhe2¹ (Simons et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Simons et al., 2009, Nat. Cell Biol. 11(3): 286--294 Electrochemical cues regulate assembly of the Frizzled/Dishevelled complex at the plasma membrane during planar epithelial polarization. [FBrf0207478]

Allele Dmel\Nhe21

Allele Dmel\Nhe2¹