Allele Dmel\Exn^EY-Δ23

General Information
Symbol	Dmel\Exn^EY-Δ23	Species	D. melanogaster
Name		FlyBase ID	FBal0241207
Feature type	allele	Associated gene	Dmel\Exn

Map ( GBrowse )
Allele class	loss of function allele
Mutagen	Delta2-3
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class	loss of function allele (Frank et al., 2009)
Mutagen	Delta2-3 (Frank et al., 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References deletion 3L:16,984,125..16,985,425 comment=Deletion resulting from the imprecise excsion of P{EPgy2}Exn[EY01953]. The endpoints were estimated from the graph and sequence in Figure 1. The second breakpoint is in an intron but the location within the intron was not reported. (Frank et al., 2009)
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	P{EPgy2}Exn^EY01953 (Frank et al., 2009)
Nature of the lesion	Statement Reference A deletion resulting from the imprecise excision of P{EPgy2}Exn[EY01953] removing a large portion of Exn. (Frank et al., 2009)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Statement Reference Exn[+]/Exn^EY-Δ23 is a non-enhancer of neurophysiology defective \| recessive \| third instar larval stage phenotype of GluRIIA^SP16 (Frank et al., 2009)
NOT Suppressor of
Statement Reference Exn[+]/Exn^EY-Δ23 is a non-suppressor of neurophysiology defective \| recessive \| third instar larval stage phenotype of GluRIIA^SP16 (Frank et al., 2009)
Other
Statement Reference Exn^EY-Δ23, GluRIIA^SP16, cac^S/cac[+] has neurophysiology defective \| recessive \| third instar larval stage phenotype (Frank et al., 2009)
Phenotype Manifest In
NOT Enhancer of
Statement Reference Exn[+]/Exn^EY-Δ23 is a non-enhancer of embryonic/larval neuromuscular junction phenotype of GluRIIA^SP16 (Frank et al., 2009)
NOT Suppressor of
Statement Reference Exn[+]/Exn^EY-Δ23 is a non-suppressor of embryonic/larval neuromuscular junction phenotype of GluRIIA^SP16 (Frank et al., 2009)
Other
Statement Reference Exn^EY-Δ23, GluRIIA^SP16, cac^S/cac[+] has embryonic/larval neuromuscular junction phenotype (Frank et al., 2009) Exn^EY-Δ23, GluRIIA^SP16 has NMJ bouton phenotype (Frank et al., 2009)
Additional Comments
Genetic Interactions
Statement Reference GluRIIA[SP16] mutant larvae, also homozygous for an Exn[EY-Δ23] allele, show a slight but significant increase in bouton number at the NMJ compared to GluRIIA[SP16] single mutants. GluRIIA[SP16] mutant larvae, also homozygous for an Exn[EY-Δ23] allele, show no difference in average active zone number per NMJ compared to GluRIIA[SP16] single mutants. The recessive GluRIIA[SP16] single mutant NMJ synaptic homeostasis phenotype is not enhanced nor suppressed by a heterozygous Exn[EY-Δ23] mutation. The recessive GluRIIA[SP16] single mutant NMJ synaptic homeostatic response is completely suppressed in the presence of a heterozygous cac[S]/+ mutation in combination with an Exn[EY-Δ23]/+ heterozygous genetic background. (Frank et al., 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescued by	Exn^EY-Δ23 is rescued by Scer\GAL4^elav-C155/Exn^{Scer\UAS.T:Avic\GFP-EYFP} (Frank et al., 2009)
Comments	Presynaptic expression of Exn[Scer\UAS.T:Avic\GFP-EYFP] driven by the pan-neuronal driver Scer\GAL4[elav-C155] in a GluRIIA[SP16]; Exn[EY-Δ23] double mutant background is sufficient to fully rescue the Exn[EY-Δ23] specific components in the abnormal neuromuscular junction synaptic homeostasis phenotypes associated with GluRIIA[SP16]; Exn[EY-Δ23] double mutants. (Frank et al., 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Exn^EY-Δ23 exn^EY-Δ23 (Frank et al., 2009)
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Frank et al., 2009, Neuron 61(4): 556--569 A presynaptic homeostatic signaling system composed of the Eph receptor, ephexin, Cdc42, and CaV2.1 calcium channels. [FBrf0207531]

Allele Dmel\ExnEY-Δ23

Allele Dmel\Exn^EY-Δ23