Allele Dmel\Lrt^{Scer\UAS.T:Avic\GFP-EGFP}

General Information
Symbol	Dmel\Lrt^{Scer\UAS.T:Avic\GFP-EGFP}	Species	D. melanogaster
Name		FlyBase ID	FBal0241219
Feature type	allele	Associated gene	Dmel\Lrt

Allele class
Mutagen	in vitro construct - regulatory fusion, in vitro construct - coding region fusion
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - coding region fusion (Wayburn and Volk, 2009) in vitro construct - regulatory fusion (Wayburn and Volk, 2009)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Scer\UAS regulatory sequences drive expression of Lrt which is tagged at the C-terminal end with T:Avic\GFP[EGFP]. (Wayburn and Volk, 2009)
Carried in construct	P{UAS-Lrt.GFP} (Wayburn and Volk, 2009)
Tagged with	T:Avic\GFP^EGFP (Wayburn and Volk, 2009)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In
	embryonic/larval somatic muscle, with Scer\GAL4^sr-md710 (Wayburn and Volk, 2009) ventral longitudinal muscle, with Scer\GAL4^sr-md710 (Wayburn and Volk, 2009)
Detailed Description
	Statement Reference Expression of Lrt[Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[sr-md710] results in an abnormal muscle phenotype in 70% of embryos; the dorsal longitudinal muscles stall close to a single segmental border and do not extend between two segmental borders in two to four segments. In 20% of these embryos, similar defects are also seen in the ventral longitudinal muscles. Expression of Lrt[Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[Mef2.PR] does not result in a mutant muscle phenotype. (Wayburn and Volk, 2009)
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressed by
Statement Reference Lrt^{Scer\UAS.T:Avic\GFP-EGFP}, Scer\GAL4^sr-md710 has embryonic/larval somatic muscle phenotype, suppressible by robo[+]/robo¹ (Wayburn and Volk, 2009)
Additional Comments
Genetic Interactions
Statement Reference robo[1]/+ completely rescues the abnormal muscle phenotype caused by expression of Lrt[Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[sr-md710]. (Wayburn and Volk, 2009)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Rescues	Lrt^{Scer\UAS.T:Avic\GFP-EGFP}/Scer\GAL4^sr-md710 rescues Df(2R)BSC403 (Wayburn and Volk, 2009)
Comments	Expression of Lrt[Scer\UAS.T:Avic\GFP-EGFP] under the control of Scer\GAL4[sr-md710] rescues the muscle defects seen in Df(2R)BSC403 homozygous embryos. (Wayburn and Volk, 2009)
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Lrt^{Scer\UAS.T:Avic\GFP-EGFP}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Wayburn and Volk, 2009, Development 136(21): 3607--3615 LRT, a tendon-specific leucine-rich repeat protein, promotes muscle-tendon targeting through its interaction with Robo. [FBrf0209122]

Allele Dmel\LrtScer\UAS.T:Avic\GFP-EGFP

Allele Dmel\Lrt^{Scer\UAS.T:Avic\GFP-EGFP}