Allele Scer\GAL4^Ilp3.PB

General Information
Symbol	Scer\GAL4^Ilp3.PB	Species	S. cerevisiae
Name	Insulin-like peptide 3 promoter construct of Buch	FlyBase ID	FBal0241232
Feature type	allele	Associated gene	Scer\GAL4

Allele class
Mutagen	in vitro construct - regulatory fusion
Recent Updates
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Nature of the Allele
Allele class
Mutagen	in vitro construct - regulatory fusion (Buch et al., 2008)
Mutations Mapped to the Genome

Type Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference An 860bp Ilp3 promoter fragment drives expression of Scer\GAL4. (Buch et al., 2008)
Carried in construct	P{Ilp3-Gal4.B} (Buch et al., 2008, Enell et al., 2010, Slack et al., 2011, Rajan and Perrimon, 2012)
Cytology
Phenotypic Data
Phenotypic Class
	long lived, with rpr^Scer\UAS.C (Slack et al., 2011) long lived \| drug conditional, with rpr^Scer\UAS.C (Slack et al., 2011) short lived \| nutrition conditional, with GABA-B-R2^{dsRNA.Scer\UAS} (Enell et al., 2010) small body, with rpr^Scer\UAS.C (Slack et al., 2011)
Phenotype Manifest In
	neurosecretory neuron, with rpr^Scer\UAS.C (Buch et al., 2008)
Detailed Description
	Statement Reference
External Data
Linkouts
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement Reference Scer\GAL4^Ilp3.PB, rpr^Scer\UAS.C has long lived \| drug conditional phenotype, suppressible \| partially by foxo^Δ94 (Slack et al., 2011) Scer\GAL4^Ilp3.PB, rpr^Scer\UAS.C has long lived phenotype, suppressible by foxo^Δ94 (Slack et al., 2011)
NOT suppressed by
Statement Reference Scer\GAL4^Ilp3.PB, rpr^Scer\UAS.C has small body phenotype, non-suppressible by foxo^Δ94 (Slack et al., 2011)
Suppressor of
Statement Reference Scer\GAL4^Ilp3.PB/Bhal\NaChBac^{Scer\UAS.T:Avic\GFP-EGFP} is a suppressor of small body \| adult stage phenotype of upd2^Δ3-62 (Rajan and Perrimon, 2012)
NOT Suppressor of
Statement Reference rpr^Scer\UAS.C/Scer\GAL4^Ilp3.PB is a non-suppressor of viable phenotype of foxo^Δ94 (Slack et al., 2011) Scer\GAL4^Ilp3.PB/Sh^{EKO.Scer\UAS.T:Avic\GFP-GL} is a non-suppressor of small body \| adult stage phenotype of upd2^Δ3-62 (Rajan and Perrimon, 2012)
Phenotype Manifest In
Suppressor of
Statement Reference Scer\GAL4^Ilp3.PB/Bhal\NaChBac^{Scer\UAS.T:Avic\GFP-EGFP} is a suppressor of wing phenotype of upd2^Δ3-62 (Rajan and Perrimon, 2012)
NOT Suppressor of
Statement Reference Scer\GAL4^Ilp3.PB/Sh^{EKO.Scer\UAS.T:Avic\GFP-GL} is a non-suppressor of wing phenotype of upd2^Δ3-62 (Rajan and Perrimon, 2012)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

External Crossreferences & Linkouts
Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	Scer\GAL4^Ilp3.PB
Name Synonym	Insulin-like peptide 3 promoter construct of Buch
Secondary FlyBase IDs

References ( 4 )
Research paper	Rajan and Perrimon, 2012, Cell 151(1): 123--137 Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. [FBrf0219535] Slack et al., 2011, Aging Cell 10(5): 735--748 dFOXO-independent effects of reduced insulin-like signaling in Drosophila. [FBrf0215229] Enell et al., 2010, PLoS ONE 5(12): e15780 Insulin Signaling, Lifespan and Stress Resistance Are Modulated by Metabotropic GABA Receptors on Insulin Producing Cells in the Brain of Drosophila. [FBrf0212696] Buch et al., 2008, Cell Metab. 7(4): 321--332 Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. [FBrf0204261]

Allele Scer\GAL4Ilp3.PB

Allele Scer\GAL4^Ilp3.PB