FlyBase Allele Report: Dmel\larp[S003108]

General Information

Symbol

Dmel\larp^S003108

Species

D. melanogaster

Name

FlyBase ID

FBal0241443

Feature type

allele

Associated gene

Dmel\larp

Associated Insertion(s)

P{lacW}larp^S003108

Carried in Construct

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Deak et al., 1997)

Mutations Mapped to the Genome

Type

Location

Additional Notes

References

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Progenitor genotype

Cytology

Nature of the lesion

Statement

Reference

P{lacW} insertion in the first intron.

(Ichihara et al., 2007)

Insertion components

P{lacW}larp^S003108

Product class / Tool use(s)

Encoded product / tool

Tagged with

nuclear protein localization tag

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Phenotypic Data

Phenotypic Class

female sterile (with larp^mtr-null)

(Blagden et al., 2009)

male sterile (with larp^mtr-null)

(Blagden et al., 2009)

meiotic cell cycle defective

(Blagden et al., 2009)

mitotic cell cycle defective (with larp^mtr-null)

(Blagden et al., 2009)

Phenotype Manifest In

embryo | embryonic stage 4 (with larp^mtr-null)

(Blagden et al., 2009)

spermatocyte

(Blagden et al., 2009)

spindle (with larp^mtr-null)

(Blagden et al., 2009)

Detailed Description

Statement

Reference

71% of larp^S003108/larp^mtr-null females are sterile.

Eggs laid by larp^S003108/larp^mtr-null females show a number of defects during syncytial divisions, including chains of linked spindles, free centrosomes, multipolar spindles, chromosome segregation defects and a loss of synchrony throughout the syncytial divisions.

35.4% of homozygous spermatocytes show defects in meiosis.

(Blagden et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

larp^S003108 has meiotic cell cycle defective phenotype, enhanceable by pAbp[+]/pAbp^EP310

(Blagden et al., 2009)

Enhancer of

Statement

Reference

larp^S003108/larp[+] is an enhancer of meiotic cell cycle defective phenotype of pAbp^EP310

(Blagden et al., 2009)

Other

Statement

Reference

larp^S003108/larp[+], pAbp^EP310 has meiotic cell cycle defective | dominant phenotype

(Blagden et al., 2009)

Phenotype Manifest In

Enhanced by

Statement

Reference

larp^S003108 has spermatocyte phenotype, enhanceable by pAbp[+]/pAbp^EP310

(Blagden et al., 2009)

Enhancer of

Statement

Reference

larp^S003108/larp[+] is an enhancer of spermatocyte phenotype of pAbp^EP310

(Blagden et al., 2009)

Other

Statement

Reference

larp^S003108/larp[+], pAbp^EP310 has spermatocyte phenotype

(Blagden et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

16% of pAbp^EP310/+ ; larp^S003108/+ double heterozygous spermatocytes show defects in meiosis.

The frequency of homozygous pAbp^EP310 spermatocytes that show defects in meiosis (17%) is increased by larp^S003108/+ (to 29.3%).

The frequency of homozygous larp^S003108 spermatocytes that show defects in meiosis (35.4%) is increased by pAbp^EP310/+ (to 48%).

(Blagden et al., 2009)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Allelic series (severity of mutant alleles): larp^mtr-null > larp^S003108 > larp^S022529 > larp⁰⁶⁴⁸⁷.

(Blagden et al., 2009)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

0031/08

(Deak et al., 1997)

l(3)S003108^S003108

l(3)S003108^l(3)S003108

(Blagden et al., 2009)

larp^S003108

larp<up>mtr w</up>

(Blagden et al., 2009)

larp^mtrw

(Ichihara et al., 2007)

mtr^w

(Ichihara et al., 2007)

Name Synonyms

Secondary FlyBase IDs

FBal0220947
FBal0130100

References (3)

Report Sections

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