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General Information
Symbol
Dmel\larpmtr-null
Species
D. melanogaster
Name
FlyBase ID
FBal0241445
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Cytology
Nature of the lesion
Statement
Reference

Recombination between the two progenitor insertion has resulted in a deletion of the intervening sequence, deleting larp sequences.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Replication of mtDNA is severely impaired in larpmtr-null mutant ovaries.

Homozygotes have shorter and thinner bristles than normal and some bristles are occasionally missing. The mutant flies also have a slight rough eye phenotype.

71% of larpS003108/larpmtr-null females are sterile.

45% of larpS022529/larpmtr-null females are sterile.

6% of larp06487/larpmtr-null females are sterile.

Homozygous females do not lay eggs.

Eggs laid by larpS003108/larpmtr-null females show a number of defects during syncytial divisions, including chains of linked spindles, free centrosomes, multipolar spindles, chromosome segregation defects and a loss of synchrony throughout the syncytial divisions.

Eggs laid by larpS022529/larpmtr-null females show a number of defects during syncytial divisions, including chains of linked spindles and free centrosomes. Time-lapse imaging shows that centrosomes can be seen to successfully duplicate following the previous division cycle, however the movement of the centrosomes around the nuclear membrane is hindered. Nonetheless, a spindle forms between the two groups of centrosomes. Nuclear spacing is also disrupted.

48.4% of homozygous spermatocytes show defects in meiosis.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement
Reference
Other
Phenotype Manifest In
Enhancer of
Statement
Reference

larpmtr-null/larp[+] is an enhancer of spermatocyte phenotype of pAbpEP310

Other
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference

23% of pAbpEP310/+ ; larpmtr-null/+ double heterozygous spermatocytes show defects in meiosis.

The frequency of homozygous pAbpEP310 spermatocytes that show defects in meiosis (17%) is increased by larpmtr-null/+ (to 31.4%).

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
Comments
Comments

Allelic series (severity of mutant alleles): larpmtr-null > larpS003108 > larpS022529 > larp06487.

External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
larp<up>mtr null</up>
larpmtr-null
Name Synonyms
Secondary FlyBase IDs
    References (2)