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General Information
Symbol
Dmel\cswN308D.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0241536
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-cswN308D
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
point mutation
Nucleotide change:

A2109797G

Amino acid change:

N340D | csw-PD; N287D | csw-PA; N387D | csw-PB; N128D | csw-PC

Reported amino acid change:

N287D

Comment:

N287D mutation reported relative to isoform csw-PA; analogous mutation in human PTPN11 implicated in Noonan syndrome 1; mutation carried on in vitro construct; site of nucleotide substitution in fly gene and specific disease association inferred by FlyBase curator.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASp regulatory sequences drive expression of csw containing the amino acid replacement N287D (this mutation is equivalent to the N308D mutation in the human ortholog Hsap\PTPN11, which is a mutation associated with Noonan syndrome in humans).

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
 

FlyBase curator comment: The mutation in cswN308D.Scer\UAS.P\T is associated with Noonan's syndrome in humans but although it results in various gain of function effects in transgenic flies it's not clear how these relate to the Noonan's syndrome phenotype.

Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of one copy of cswN308D.Scer\UAS.P\T under the control of Scer\GAL4tub.PU does not result in lethality, whereas expression of two copies results in lethality.

Flies expressing one copy of cswN308D.Scer\UAS.P\T under the control of Scer\GAL4tub.PU have ectopic wing veins, mainly in the peripheral areas of vein L2 and the posterior cross vein.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by aos[+]/aosΔ7

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by E(spl)m8-HLHrv1/E(spl)m8-HLH[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by lack[+]/SmurfKG07014

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by Stat92E[+]/Stat92E06346

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by hop27/hop[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by bs[+]/bsk07909

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by lace[+]/lace2

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by Gap1[+]/RasGAP1B2

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by sty[+]/sty226

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by Dl6B/Dl[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, enhanceable by Dl9P/Dl[+]

NOT Enhanced by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-enhanceable by spi1/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-enhanceable by spi259/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-enhanceable by dos[+]/dosP115

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-enhanceable by Raf7/phl[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-enhanceable by CblKG03080/Cbl[+]

Suppressed by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Egfr[+]/Egfrt1

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Sos[+]/Sos34Ea-6

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by drk[+]/drke0A/drke0A

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Ras85De1B/Ras85D[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Hsp83[+]/Hsp83e6A

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Hsp83e6D/Hsp83[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Dsor1[+]/Dsor1LH110

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Dsor1[+]/Dsor1S-1221

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by vn[+]/vn10567

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by pnt[+]/pntΔ88

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by pnt[+]/pnt1230

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by E(spl)m8-HLH1/E(spl)m8-HLH[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Su(H)[+]/Su(H)1

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by dpp10638/dpp[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by dppd6/dpp[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by dppd-ho/dpp[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by tkv1/tkv[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by tkv7/tkv[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by vn[+]/vnC221

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Mad[+]/Mad1-2

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Mad8-2/Mad[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by hopTum/hop[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by Sk09530/S[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, suppressible by S[+]/SIIN

NOT suppressed by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-suppressible by spi1/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-suppressible by spi259/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-suppressible by dos[+]/dosP115

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-suppressible by Raf7/phl[+]

Scer\GAL4Tub.PU, cswN308D.UASp has visible phenotype, non-suppressible by CblKG03080/Cbl[+]

Phenotype Manifest In
Enhanced by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by aos[+]/aosΔ7

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by E(spl)m8-HLHrv1/E(spl)m8-HLH[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by Stat92E[+]/Stat92E06346

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by hop27/hop[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by lace[+]/lace2

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by sty[+]/sty226

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by Dl6B/Dl[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, enhanceable by Dl9P/Dl[+]

NOT Enhanced by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-enhanceable by spi1/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-enhanceable by spi259/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-enhanceable by dos[+]/dosP115

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-enhanceable by Raf7/phl[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-enhanceable by CblKG03080/Cbl[+]

Suppressed by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Egfr[+]/Egfrt1

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Ras85De1B/Ras85D[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by vn[+]/vn10567

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Hsp83[+]/Hsp83e6A

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Hsp83e6D/Hsp83[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Dsor1[+]/Dsor1LH110

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Dsor1[+]/Dsor1S-1221

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by pnt[+]/pntΔ88

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by pnt[+]/pnt1230

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by E(spl)m8-HLH1/E(spl)m8-HLH[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Su(H)[+]/Su(H)1

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by vn[+]/vnC221

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by dpp10638/dpp[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by dppd6/dpp[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by dppd-ho/dpp[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by tkv1/tkv[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by tkv7/tkv[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Mad[+]/Mad1-2

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by Mad8-2/Mad[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by hopTum/hop[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, suppressible by S[+]/SIIN

NOT suppressed by
Statement
Reference

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-suppressible by spi1/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-suppressible by spi259/spi[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-suppressible by dos[+]/dosP115

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-suppressible by Raf7/phl[+]

Scer\GAL4Tub.PU, cswN308D.UASp has wing vein | ectopic phenotype, non-suppressible by CblKG03080/Cbl[+]

Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Partially rescues
Comments

Expression of cswN308D.Scer\UAS.P\T under the control of Scer\GAL4GMR.PU partially rescues the rough eye phenotype of cswlf flies.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
cswN308D.Scer\UAS.P\T
cswN308D.Scer\UAS
cswN308D.UASp
Name Synonyms
Secondary FlyBase IDs
    References (4)