FlyBase Allele Report: Dmel\Rab5[JF03335]

General Information

Symbol

Dmel\Rab5^JF03335

Species

D. melanogaster

Name

FlyBase ID

FBal0241752

Feature type

allele

Associated gene

Dmel\Rab5

Associated Insertion(s)

Carried in Construct

P{TRiP.JF03335}

Also Known As

rab5^RNAi, JF03335, Rab5 RNAi, UAS-Rab5 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF03335}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF03335

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates amyotrophic lateral sclerosis type 15

modeled by Hsap\UBQLN2^WT.UAS

(Kim et al., 2023)

modeled by Hsap\UBQLN2^P4X.UAS

(Kim et al., 2023)

modeled by Hsap\UBQLN2^P497H.UAS

(Kim et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

Phenotype Manifest In

embryonic/larval cell body glial cell | third instar larval stage, with Hsim\VP16^AD.nrv2, Scer\GAL4^{DBD.wrapper.932i}

(Coutinho-Budd et al., 2017)

Detailed Description

Statement

Reference

Expression of Rab5^JF03335 under the control of CtxGlia-SplitGal4 (Hsim\VP16^AD.nrv2 and Scer\GAL4^{DBD.wrapper.932i}) leads to an altered cortex glial morphology in third instar larvae when compared to controls.

(Coutinho-Budd et al., 2017)

Expression of Rab5^JF03335 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

(Ugrankar et al., 2015)

Expression of Rab5^JF03335 (co-expressed with Dcr-2^Scer\UAS.cDa) in epidermal cells under the control of Scer\GAL4^5-56 does not prevent phagocytic clearance of ddaC neuron dendrite debris following pupal stage dendritic pruning.

(Han et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Rab5^JF03335, Scer\GAL4^GMR.PU is an enhancer of abnormal eye color phenotype of Hsap\UBQLN2^P4X.UAS, Scer\GAL4^GMR.PU

(Kim et al., 2023)

Other