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Allele Dmel\unc-104116
| General Information | |||
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| Symbol | Dmel\unc-104116 | Species | D. melanogaster |
| Name | FlyBase ID | FBal0241897 | |
| Feature type | allele | Associated gene | Dmel\unc-104 |
| Allele class | |||
| Mutagen | |||
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| Description |
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| FB2013_03 | |||
| FB2013_02 | |||
| All updates | Click here to see a list of all updates to this record from FB2010_08 and on. | ||
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Nature of the Allele
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| Allele class | |||
| Mutagen | |||
| Mutations Mapped to the Genome | |||
Type Location Additional Notes References | |||
| Associated Sequence Data | |||
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EMBL / GenBank | DNA sequence Protein sequence Name | ||
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| Progenitor genotype | |||
| Nature of the lesion | Statement Reference Mutation of a splice site within the predicted coiled-coil domain. | ||
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Phenotypic Data
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Phenotypic Class
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Phenotype Manifest In
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Detailed Description
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Statement Reference Homozygous unc-104[116] mutant eyes externally appear normal and their ERGs show robust responses to light. However, the 'on-off transients' of ERG, which require synchronous synaptic transmission from the photoreceptors to second-order neurons, are absent in homozygous mutant eyes.
Homozygous unc-104[116] mutant flies die as unhatched late-stage embryos. The gross morphology of these embryos is comparable to that of a wild-type fly that has completed embryogenesis 20-22hrs after egg-laying. The mutants, however, are paralyzed and lack the coordinated muscle peristalsis required for hatching.
Homozygous unc-104[116] mutant embryos, despite normal axonal outgrowth and targeting, ISNb axon contacts lack extended branches. Filipodia-like structures are sometimes found, but not restricted to muscle boundaries. At 21 hours AEL, the nerve is visible in its target regions, but the contacts have not transformed into mature synapses; the nerves lack the bead-like boutons seen in wild-type embryos. Instead, the endings and their branches are more constricted than those at 14 hours AEL and frequently retain some filipodia-like processes. This phenotype is completely penetrant, observed in every abdominal segment. At times, axons at the boundary of muscles 12 and 13 are not found, raising the possiblity that some have retracted. Occasionally, ectopic projections from neighboring nerves are found. However, those that form in unc-104[116] mutants do not have boutons. Consequently, both the normal innervation and the occasionally ectopic projection are incapable of normal morphogenesis. | |||
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External Data
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Interactions
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Phenotypic Class
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Phenotype Manifest In
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Additional Comments
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Genetic Interactions
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Statement Reference | |||
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Xenogenetic Interactions
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Statement Reference | |||
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Complementation & Rescue Data
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Stocks
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Notes on Origin
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 External Crossreferences & Linkouts
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Synonyms & Secondary IDs
( 2 ) | |||
| Reported As | |||
| Symbol Synonym | imac116 unc-104116 | ||
| Name Synonym | |||
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References
( 1 ) | |||
| Research paper |
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